Table_1_TMP269, a small molecule inhibitor of class IIa HDAC, suppresses RABV replication in vitro.XLS by Juanbin Yin (17523177)

“…Further exploration shows that autophagy enhances RABV replication in HEK-293T cells, while TMP269 can inhibit autophagy to decrease RABV replication. Together, these results provide a novel treatment strategy for rabies.…”

Table_2_TMP269, a small molecule inhibitor of class IIa HDAC, suppresses RABV replication in vitro.XLS by Juanbin Yin (17523177)

“…Further exploration shows that autophagy enhances RABV replication in HEK-293T cells, while TMP269 can inhibit autophagy to decrease RABV replication. Together, these results provide a novel treatment strategy for rabies.…”

Table_3_TMP269, a small molecule inhibitor of class IIa HDAC, suppresses RABV replication in vitro.XLS by Juanbin Yin (17523177)

“…Further exploration shows that autophagy enhances RABV replication in HEK-293T cells, while TMP269 can inhibit autophagy to decrease RABV replication. Together, these results provide a novel treatment strategy for rabies.…”

Comparing efficacies of moxifloxacin, levofloxacin and gatifloxacin in tuberculosis granulomas using a multi-scale systems pharmacology approach - Fig 10 by Elsje Pienaar (658131)

“…<p>Bacteria in all subpopulations increase more slowly following MXF treatment interruption, compared to GFX and LVX (A-D). Lines show means of 210 <i>in silico</i> granulomas, with infection starting at day 0, daily FQ treatment starting at day 380 (arrows). …”

Silencing GRK2 and GRK3 attenuate C3aR desensitization but GRK5 and GRK6 do not. by Qiang Guo (218747)

“…<p>(A) shRNA control, (B) GRK2, (C) GRK3, (D) GRK5 and (E) GRK6 KD cells were loaded with Indo-1 (1 µM), stimulated with C3a (100 nM) for 5 min and intracellular Ca²⁺ mobilization was determined (black solid lines). …”

Table_4_TMP269, a small molecule inhibitor of class IIa HDAC, suppresses RABV replication in vitro.XLS by Juanbin Yin (17523177)

“…Further exploration shows that autophagy enhances RABV replication in HEK-293T cells, while TMP269 can inhibit autophagy to decrease RABV replication. Together, these results provide a novel treatment strategy for rabies.…”

Image 3_A multi-omics approach to unravel the interaction between heat and drought stress in the Arabidopsis thaliana holobiont.png by Biancamaria Senizza (10923828)

“…Overall, phenylpropanoids and nitrogen-containing compounds, hormones and amino acids showed the highest discriminant potential. A decrease in alpha-diversity of Bacteria was observed upon stress, with stress-dependent differences in bacterial microbiota composition. …”

Table 4_A multi-omics approach to unravel the interaction between heat and drought stress in the Arabidopsis thaliana holobiont.xlsx by Biancamaria Senizza (10923828)

“…Overall, phenylpropanoids and nitrogen-containing compounds, hormones and amino acids showed the highest discriminant potential. A decrease in alpha-diversity of Bacteria was observed upon stress, with stress-dependent differences in bacterial microbiota composition. …”

A chemical similarity network of identified metabolites was used to visualize OGTT-associated changes in metabolite levels following an OGTT in women. by Caitlin Campbell (507411)

Table 2_A multi-omics approach to unravel the interaction between heat and drought stress in the Arabidopsis thaliana holobiont.xlsx by Biancamaria Senizza (10923828)

“…Overall, phenylpropanoids and nitrogen-containing compounds, hormones and amino acids showed the highest discriminant potential. A decrease in alpha-diversity of Bacteria was observed upon stress, with stress-dependent differences in bacterial microbiota composition. …”

Selected model input parameters for a simulation model of strategies to prevent mother-to-child transmission of HIV in Zimbabwe: Pediatric data. by Andrea L. Ciaranello (188588)

“…</p><p>*“Without sdNVP exposure” refers to situations in which sdNVP was not received, or was received in combination with short-course zidovudine or other antenatal/intrapartum medications which may decrease risk of NVP-associated NNRTI-resistant HIV <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0020224#pone.0020224-Arrive1" target="_blank">[19]</a>.…”

Long-Term Retrospective Analysis of Mackerel Spawning in the North Sea: A New Time Series and Modeling Approach to CPR Data by Teunis Jansen (114728)

“…<div><p>We present a unique view of mackerel (<em>Scomber scombrus</em>) in the North Sea based on a new time series of larvae caught by the Continuous Plankton Recorder (CPR) survey from 1948-2005, covering the period both before and after the collapse of the North Sea stock. …”

Decomposition of mortality rates from cardiovascular disease in the adult population: a study for Brazilian micro-regions between 1996 and 2015 by Emerson Augusto Baptista (5716349)

“…The results suggest there has been a decrease in mortality rates resulting from cardiovascular disease, and that both the effects of age structure and level may have influenced the variation of these deaths in Brazil over the period analyzed. …”

Image 2_A multi-omics approach to unravel the interaction between heat and drought stress in the Arabidopsis thaliana holobiont.png by Biancamaria Senizza (10923828)

“…Overall, phenylpropanoids and nitrogen-containing compounds, hormones and amino acids showed the highest discriminant potential. A decrease in alpha-diversity of Bacteria was observed upon stress, with stress-dependent differences in bacterial microbiota composition. …”

Table 1_A multi-omics approach to unravel the interaction between heat and drought stress in the Arabidopsis thaliana holobiont.xlsx by Biancamaria Senizza (10923828)

“…Overall, phenylpropanoids and nitrogen-containing compounds, hormones and amino acids showed the highest discriminant potential. A decrease in alpha-diversity of Bacteria was observed upon stress, with stress-dependent differences in bacterial microbiota composition. …”

K294E change in the rotavirus factory forming protein NSP2 stabilizes a rare C-terminal conformation by Sarah L. Nichols (22316634)

“…These results provide mechanistic insights into how a single amino acid change in the NSP2 C-terminus can have large effects on structural ensemble, shedding light on features of the protein that underpin RV viroplasm formation.…”

High-content small molecule screen of SCPN/CSN molecular refinement by mES-derived neurons identified candidate small molecule regulators, including the SIRT1 inhibitor EX-527. by Cameron Sadegh (11378606)

“…(C) Candidate small molecules, from the box marked in (B), decreased the number of SATB2-expressing neurons relative to <i>Fezf2</i> induction alone; these top candidates are enclosed in a new box and highlighted in orange text (in order to identify them in the prior analyses in panels A and B); they include the SIRT1 inhibitor EX-527. …”

Longitudinal engagement trajectories and risk of death among new ART starters in Zambia: A group-based multi-trajectory analysis by Aaloke Mody (602279)

“…Identified groups exhibited large differences in survival: after adjustment, the “early LTFU with reengagement” group (aIRR 3.4 [95% CI 1.2–9.7], <i>p =</i> 0.019), the “early LTFU” group (aIRR 6.4 [95% CI 2.5–16.3], <i>p <</i> 0.001), and the “late LTFU” group (aIRR 4.7 [95% CI 2.0–11.3], <i>p =</i> 0.001) had higher rates of mortality as compared to the group with consistently high adherence/retention. …”

Table 1_Effect of a mindfulness-based cognitive behavior therapy intervention on occupational burnout among school teachers.docx by Netra Raj Paudel (20610806)

“…The mean level of DP also decreased in the treatment arm (-0.12, 95% CI: -0.98 to -0.75), but a sharper decline was observed in the control arm (-1.97, 95% CI: -2.78 to -1.16). …”

Data_Sheet_1_Relationship Between Serum Albumin and Risk of Atrial Fibrillation: A Dose-Response Meta-Analysis.pdf by Yali Wang (332169)

“…Patients with high albumin level were associated with a decreased risk of atrial fibrillation compared with patients with low serum albumin (OR[odds ratio]: 0.62, 95% CI [0.44, 0.89]; I² = 76%; P = 0.009). …”