Selective Attenuation of Norepinephrine Release and Stress-Induced Heart Rate Increase by Partial Adenosine A₁ Agonism by Lorenz Bott-Flügel (226405)

“…Under control conditions (S1), NE release was significantly higher in SHR hearts compared to Wistar (766+/−87 pmol/g vs. 173+/−18 pmol/g, p<0.01). Capadenoson led to a concentration-dependent decrease of the stimulation–induced NE release in SHR (S2/S1 = 0.90±0.08 with capadenoson 6 · 10⁻⁸ M, 0.54±0.02 with 6 · 10⁻⁷ M), but not in Wistar hearts (S2/S1 = 1.05±0.12 with 6 · 10⁻⁸ M, 1.03±0.09 with 6 · 10⁻⁷ M). …”

Table_1_Identification and Validation of Novel Immune-Related Alternative Splicing Signatures as a Prognostic Model for Colon Cancer.xlsx by Yunze Liu (11410635)

“…Background<p>Individual immune-related alternative splicing (AS) events have been found to be significant in immune regulation and cancer prognosis. However, a comprehensive analysis of AS events in cancer cells based on immune-related genes (IRGs) has not been performed, and its clinical value is unknown.…”

Evaluation Selenocysteine Protective Effect in Carbon Disulfide Induced Hepatitis with a Mitochondrial Targeting Ratiometric Near-Infrared Fluorescent Probe by Xiaoyue Han (4906438)

“…The results indicate that CS₂ exposure can lead to a decrease of Sec level and result in mitochondrial related acute inflammation. …”

Data_Sheet_1_Capturing a Comprehensive Picture of Biological Events From Adverse Outcome Pathways in the Drug Exposome.docx by Qier Wu (11848085)

“…Such scores have the potential to quantify the uncertainty of an event involved in an AON, and could be valuable for the weight of evidence assessment of AOPs. A case study related to infertility, more specifically to “decrease, male agenital distance” is presented.…”

Image_1_Effects of Comedication and Genetic Factors on the Population Pharmacokinetics of Lamotrigine: A Prospective Analysis in Chinese Patients With Epilepsy.tif by Zhan-zhang Wang (7038317)

“…The CL/F decreased by 52.5% in SLC22A1-1222AA carriers. Patients with the ABCG2-34AA genotype had a 42.0% decrease in V/F, whereas patients with the MDR1-2677TT and C3435TT genotypes had a 136% increase in V/F. …”

Image_2_Chronic Consumption of a Commercial Energy Drink Reduces Blood Pressure in Normotensive Wild-Type Mice.tiff by Liam Graneri (7023866)

“…</p><p>Research Methods and Procedures: Groups of mice were randomized to no treatment (water) (Control group), or to Mother^™ provided as a decarbonated 30% (v/v) drinking solution (Energy Drink group), sugar-free Mother^™ at 30% (Sugar-free group), Coca Cola^™ at 30% (Coke group) for a total intervention period of 13 weeks.…”

Data_Sheet_1_Tranexamic Acid for Acute Spontaneous Intracerebral Hemorrhage: A Meta-Analysis of Randomized Controlled Trials.docx by Yu Guo (102701)

“…Importantly, the decreased risk was observed in patients who were treatable within 4.5 h and with a high risk of HE, but not in those who were treatable over 4.5 h and in standard-risk population. …”

Video_2_Deep Brain Stimulation Surgery for Parkinson Disease Coexisting With Communicating Hydrocephalus: A Case Report.MP4 by Carlos Guevara (6003911)

“…There was a 71% decrease in the UPDRS III score during the on-stimulation state (28 to 8). …”

Table_2_Challenges in Maintaining the Hemostatic Balance in Children Undergoing Extracorporeal Membrane Oxygenation: A Systematic Literature Review.pdf by Joppe G. F. Drop (9774410)

“…Two studies revealed an association between anti-factor Xa assay-based protocols and a decreased number of transfusions, bleedings and need for circuit change.…”

Table 1_The impact of telework on absenteeism, presenteeism, and return to work among workers with health conditions: a scoping review.docx by Julien Ducas (20501079)

“…In contrast, findings on presenteeism are conflicting: some studies report that telework increases the likelihood of working while sick, others suggest a decrease, and some report no significant impact or conflicting results. …”

Opioid analgesics for chronic noncancer pain in patients prescribed opioid agonist therapy or with opioid use disorder: A systematic review by Vahid Ashoorion (6671855)

“…<p>Opioid use disorder (OUD) is a growing public health concern in North America, often coexisting with chronic noncancer pain (CNCP). …”

Upper Airway Changes after Orthodontic Extraction Treatment in Adults: A Preliminary Study using Cone Beam Computed Tomography by Jingjing Zhang (163589)

“…</p><p>Conclusions</p><p>The airway changes after orthodontic treatment with premolar extraction and maximum anchorage in adults are mainly morphological changes with anteroposterior dimension compressed in airway cross sections, rather than a decrease in size.</p></div>…”

Table_2_Recombinant FSH Improves Sperm DNA Damage in Male Infertility: A Phase II Clinical Trial.DOCX by Nicola Colacurci (471337)

“…<p>Background and objectives: Male infertility is a global health dilemma and Follicle-Stimulating Hormone (FSH) administration has shown promising results. …”

(a) EOF1 of storm track density interannual variability in JJA for period 1948–2011 and (b) the corresponding PC1 by Buwen Dong (557113)

“…It is also closely related to the Summer North Atlantic Oscillation (SNAO). (2) A southward shift is associated with a downstream extension of the storm track and a decrease in blocking frequency over the UK and northwestern Europe. (3) The southward shift is associated with enhanced precipitation over the UK and northwestern Europe and decreased precipitation over southern Europe (contrary to the behaviour in winter). (4) There are strong ocean–atmosphere interactions related to the dominant mode of storm track variability. …”

Table_3_Challenges in Maintaining the Hemostatic Balance in Children Undergoing Extracorporeal Membrane Oxygenation: A Systematic Literature Review.pdf by Joppe G. F. Drop (9774410)

“…Two studies revealed an association between anti-factor Xa assay-based protocols and a decreased number of transfusions, bleedings and need for circuit change.…”

Image_2_Identification and Validation of Novel Immune-Related Alternative Splicing Signatures as a Prognostic Model for Colon Cancer.tif by Yunze Liu (11410635)

“…Background<p>Individual immune-related alternative splicing (AS) events have been found to be significant in immune regulation and cancer prognosis. However, a comprehensive analysis of AS events in cancer cells based on immune-related genes (IRGs) has not been performed, and its clinical value is unknown.…”

Image1_Deuterated Linoleic Acid Attenuates the RBC Storage Lesion in a Mouse Model of Poor RBC Storage.JPEG by Christopher Y. Kim (12458286)

“…If lipid peroxidation is a causal factor in the RBC storage lesion, incorporation of deuterated linoleic acid (DLA) into the RBC membrane should decrease lipid peroxidation, thereby improving RBC lifespan, deformability, filterability, and post-transfusion recovery (PTR) after cold storage.…”

Neonatal RSV A2 infection rapidly induces Treg suppressive functions to dampen the Th2 and Tc2 responses. by Thomas Démoulins (517537)

“…<p>(A) RSV A2 infection in neonates led to the recruitment of Tregs in the bronchoalveolar space, but not in peribronchial LNs or lung tissue. …”

Association between early serum cholinesterase activity and 30-day mortality in sepsis-3 patients: A retrospective cohort study by Zheng-Liang Peng (5703410)

“…<div><p>Low serum cholinesterase (SCHE) activity has been associated with poor prognoses in a variety of conditions, including sepsis. However, such an association has not been well characterized since the Third International Consensus Definitions Task Force modified the definition of sepsis to “life-threatening organ dysfunction due to a dysregulated host response to infection” (known as sepsis-3) in 2016. …”

DataSheet_1_Monocarboxylate Transporter 4 in Cancer-Associated Fibroblasts Is a Driver of Aggressiveness in Aerodigestive Tract Cancers.pdf by Marina Domingo-Vidal (12909533)

“…It is unknown if glycolytic metabolism in CAFs is a driver of ADT cancer aggressiveness. In this study, co-cultures in vitro and co-injections in mice of ADT carcinoma cells with fibroblasts were used as experimental models to study the effects of fibroblasts on metabolic compartmentalization, oxidative stress, carcinoma cell proliferation and apoptosis, and overall tumor growth. …”