Drug-Free Mesoporous Silica Nanoparticles Enable Suppression of Cancer Metastasis and Confer Survival Advantages to Mice with Tumor Xenografts by Yu-Tse Lee (19944891)

“…In vivo studies showed that overall tumor metastasis decreased in 4T1 xenografts mice treated with MSN-PEG/TA 25 with a notable reduction in lung tumor metastasis. …”

Image_1_Geographic Variation in the Petiole–Lamina Relationship of 325 Eastern Qinghai–Tibetan Woody Species: Analysis in Three Dimensions.pdf by Yanan Li (94033)

“…Understanding environmental gradients in the relationship and its underlying mechanisms remains a critical challenge for ecologists. We investigated the possible scaling of the petiole–lamina relationships in three dimensions, i.e., petiole length (PL) vs. lamina length (LL), petiole cross sectional area (PCA) vs. lamina area (LA), and petiole mass (PM) vs. lamina mass (LM), for 325 Qinghai–Tibetan woody species, and examined their relation to leaf form, altitude, climate, and vegetation types. …”

Effect of SILD on STZ-diabetic kidney: modulation of macrophage infiltration. by Mary Anna Venneri (737094)

“…<p>(A) Representative photomicrographs of H&E-stained kidneys (×200 magnification) on harvesting show normal structure in the CTRL and SILD, mild mesangial expansion and tubular damage in the STZ, and normal structure in the STZ+SILD group (bar represents 100 μm).…”

DataSheet1_Krill Oil Alleviated Methamphetamine-Induced Memory Impairment via the MAPK Signaling Pathway and Dopaminergic Synapse Pathway.XLSX by Qin Ru (11623021)

“…The combination of network pharmacology approaches with experimental validation may offer a useful tool to characterize the molecular mechanism of multicomponent complexes.…”

Table1_HSP90 Inhibitor 17-AAG Attenuates Nucleus Pulposus Inflammation and Catabolism Induced by M1-Polarized Macrophages.DOCX by Shuo Zhang (30844)

“…In conclusion, HSP90 inhibitor 17-AAG attenuates NP inflammation and catabolism induced by M1 macrophages, suggesting 17-AAG as a promising candidate for IVDD treatment.</p>…”

MCT4/CD147 transporter complex-associated cell proliferation, migration and invasion in U87 and U251 cell lines. by Chen Gao (159491)

“…<p><b>A.</b> Cell proliferation curves of U251 cells. …”

Table2_Deciphering the mechanism of PSORI-CM02 in suppressing keratinocyte proliferation through the mTOR/HK2/glycolysis axis.XLSX by Maojie Wang (807580)

“…<p>Hyperplasia of epidermal keratinocytes that depend on glycolysis is a new hallmark of psoriasis pathogenesis. Our previous studies demonstrated that PSORI-CM02 could halt the pathological progression of psoriasis by targeting inflammatory response and angiogenesis, but its effect(s) and mechanism(s) on proliferating keratinocytes remained unclear. …”

Spanish real-world experience with fingolimod in relapsing-remitting multiple sclerosis patients: MS NEXT study by Francisco Barrero (8662047)

“…</p><p>Methods</p><p>This observational, retrospective, multicentre, nationwide study was performed at 56 Spanish hospitals and involved 804 RRMS patients who received oral fingolimod (0.5 mg) since November 2011, with a minimum follow-up of 12 months.</p><p>Results</p><p>The mean annualized relapse rate (ARR) in the year before fingolimod was 1.08 and the median EDSS was 3; patients were exposed to fingolimod for 2.2 years as average; regarding magnetic resonance imaging (MRI) activity, more than half of the patients had >20 lesions at baseline. …”

Table_3_Alterations of the gut microbiota in patients with immunoglobulin light chain amyloidosis.xlsx by Jipeng Yan (8473710)

“…Notably, 5 optimal ASV-based microbial markers were identified as the diagnostic model of AL amyloidosis and the AUC value of the train set and the test set was 0.8549 (95% CI 0.7310-0.9789) and 0.8025 (95% CI 0.5771-1), respectively. With a median follow-up of 19.0 months, further subgroup analysis also demonstrated some key gut microbial markers were related to disease severity, treatment response, and even prognosis of patients with AL amyloidosis.…”

Image_1_Precision immunointerception of EGFR-driven tumorigenesis for lung cancer prevention.jpeg by Jing Pan (95938)

“…In this study, we identified immunogenic epitopes for the common EGFR mutations in humans and formulated a multi-peptide vaccine (E^mut Vax) targeting the EGFR L858R, T790M, and Del19 mutations. …”

Image_5_Modulation of intestinal IL-37 expression and its impact on the epithelial innate immune response and barrier integrity.tif by Laura Kröhn (17011479)

“…However, higher IL37 expression correlated with a reduced proinflammatory cytokine response in murine colonic organoids. …”

Investigation on the morphological and optical evolution of bimetallic Pd-Ag nanoparticles on sapphire (0001) by the systematic control of composition, annealing temperature and ti... by Puran Pandey (784356)

“…Depending on the annealing temperature, Pd-Ag alloy nanostructures evolve with a series of configurations, i.e. nucleation of voids, porous network, elongated nanoclusters and round alloy NPs. …”

Data_Sheet_2_RETRACTED: Endothelial-Monocyte Activating Polypeptide II Suppresses the In Vitro Glioblastoma-Induced Angiogenesis by Inducing Autophagy.DOC by Zhiqing Li (174007)

“…<p>The obstacle in delivering therapeutics to glioblastoma (GBM) is tumor-induced angiogenesis which leads to the formation of abnormal vessels and a dysfunctional blood-tumor barrier. Here, we elucidated the effect of endothelial-monocyte activating polypeptide II (EMAP II) on the GBM-induced angiogenesis as well as its potential mechanisms. …”

Image_6_Response of bacterial communities (Marivita, Marinobacter, and Oceanicaulis) in the phycosphere to the growth of Phaeodactylum tricornutum in different inorganic nitrogen s... by Xiaoxue Wei (14672540)

“…Our results explain when and how the phycosphere bacterial communities responded to algal biomass variations. The study provides a foundation for the quantitative relationship among nutrients, microalgae, and bacteria in this system.…”

DataSheet1_Sanqi Oral Solution Mitigates Proteinuria in Rat Passive Heymann Nephritis and Blocks Podocyte Apoptosis via Nrf2/HO-1 Pathway.pdf by Xiaowan Wang (9704207)

“…To investigate the effects of SQ, we established the experimental passive Heymann nephritis (PHN) rat model induced by anti-Fx1A antiserum in vivo and doxorubicin hydrochloride (ADR)-injured apoptotic podocyte model in vitro. …”

Differing Endoplasmic Reticulum Stress Response to Excess Lipogenesis versus Lipid Oversupply in Relation to Hepatic Steatosis and Insulin Resistance by Lu-Ping Ren (183886)

“…Male C57BL/6J mice were fed either a high fructose (HFru) or high fat (HFat) diet to induce DNL or lipid oversupply in/to the liver. …”

Table_3_Change of mortality of patients with acute ischemic stroke before and after 2015.docx by Sang-Won Park (180226)

“…</p>Materials and methods<p>A retrospective cohort study was conducted using combined anonymized data from the Acute Stroke Assessment Registry of Korea and the Health Insurance Review & Assessment Service database. …”

Multiomics Point of Departure (moPOD) Modeling Supports an Adverse Outcome Pathway Network for Ionizing Radiation by You Song (587198)

“…The functional assays showed increased oxidative stress and decreased mitochondrial membrane potential and ATP pool. …”

Table 1_Anti-Müllerian hormone, sex steroids, and metabolic profile in cord blood of pregnancies with type 2 diabetes and gestational diabetes.docx by Claudio Villarroel (808234)

“…Only pregnancies carrying a female offspring were included. AMH, sex steroids, and metabolic function biomarkers, including glucose, insulin, IGF-1, and adiponectin (APN) were measured. …”

Image_2_Prednisolone Suppresses the Extracellular Release of HMGB-1 and Associated Inflammatory Pathways in Kawasaki Disease.tif by Kentaro Ueno (9253486)

“…Following treatment of KD serum-activated HCAECs with PSL or PBS as a control, effects on the HMGB-1 signaling pathway were evaluated. …”