Confirmation of miRNA level by RT-qPCR. by Qin-Min Ge (3838885)

“…<p>Relative expression of each miRNA was normalized to hsa-miR-423-5p level. miR-142-5p, miR-22-3p, miR-191-5p, miR-23a-3p and miR-4456 were significantly decreased in both the sepsis-induced AKI and sepsis-non AKI groups compared with the healthy controls. miR-4270, miR-4321 and miR-3165 were obviously increased in the sepsis-induced AKI, and miR-3165 also was obviously increased in sepsis-non AKI group compared with the healthy controls. …”

KDM2A-SF and KDM2B-SF bind to the repressed axin 2 and cyclin D1 promoter regions. by Dijana Lađinović (9565428)

“…</b> The levels of H3K4me3 on the <i>AXIN2</i> promoter rose after the treatment with BIO and then decreased in the presence of the KDM2A isoforms. <b>D.…”

Edited P19 cells exhibited higher β-catenin/TCF transcription, as well as increased survivin/BIRC5 expression. by Masaya Ono (233238)

“…<p>A. Edited P19 cells exhibited significantly higher β-catenin/TCF transcription compared with wild type (WT) cells under basal conditions, as assessed by Topflash/Fopflash (TOP/FOP) activity. n = 3, *p < 0.05. …”

Comparative Proteomics Analysis of Bacillus amyloliquefaciens SQR9 Revealed the Key Proteins Involved in in Situ Root Colonization by Meihua Qiu (1710367)

“…The proteins that were closely affiliated with the root colonization belonged to the functional categories of biocontrol, detoxification, biofilm formation, cell motility and chemotaxis, transport, and degradation of plant polysaccharides. A two-component system protein ResE was increased 100-fold when compared to the planktonic status; impairment of the <i>resE</i> gene postponed the formation of cell biofilm and decreased the root colonization capability, which may be regulated through the <i>spo0A</i>-<i>sinI</i>-<i>yqxM</i> pathway. …”

miR-126-3p overexpression inhibits cellular proliferation, and colony and spheroid formation. by Yin Xiong (342546)

“…<p><b>(A–C)</b> Thyroid cancer cell line proliferation with miR-126-3p overexpression. …”

La₂Co₂Se₂O₃: A Quasi-Two-Dimensional Mott Insulator with Unusual Cobalt Spin State and Possible Orbital Ordering by Cao Wang (1500691)

“…The as-prepared sample shows insulating behavior with room-temperature resistivity of ∼10⁷ Ω cm, which decreases by 4 orders of magnitude under a pressure of 7 GPa. …”

Accelerated Lactate Dehydrogenase Activity Potentiates Osteoclastogenesis via NFATc1 Signaling by Heejin Ahn (3173670)

“…On the contrary, depletion of LDH-A or LDH-B subunit suppressed both glycolytic and mitochondrial metabolism, resulting in reduced mature osteoclast formation via decreased osteoclast precursor fusion and down-regulation of the osteoclastogenic critical transcription factor NFATc1 and its target genes. …”

5-Aza-2’-deoxycytidine in the medial prefrontal cortex regulates alcohol-related behavior and Ntf3-TrkC expression in rats by Xiaomeng Qiao (3139755)

“…Moreover, both of the mRNA and protein levels of DNA Methyltransferase 3A (DNMT3A) and DNMT3B in the mPFC were upregulated after 35 days of alcohol exposure and this upregulation could be reversed by 5-Aza-dc treatment. …”

Impact of Microbiota on Resistance to Ocular <i>Pseudomonas aeruginosa</i>-Induced Keratitis by Abirami Kugadas (3131940)

“…Cumulatively, these data underline a previously unappreciated role for microbiota in regulating susceptibility to ocular keratitis. …”

A Localized Chimeric Hydrogel Therapy Combats Tumor Progression through Alteration of Sphingolipid Metabolism by Sanjay Pal (4251406)

“…Therefore, targeting these processes using localized delivery of a minimally toxic drug combination may be a promising strategy. …”

A Localized Chimeric Hydrogel Therapy Combats Tumor Progression through Alteration of Sphingolipid Metabolism by Sanjay Pal (4251406)

“…Therefore, targeting these processes using localized delivery of a minimally toxic drug combination may be a promising strategy. …”

The Nucleosome Acidic Patch Regulates the H2B K123 Monoubiquitylation Cascade and Transcription Elongation in <i>Saccharomyces cerevisiae</i> by Christine E. Cucinotta (779688)

“…Specifically, we performed a synthetic lethal screen with cells lacking <i>RKR1</i> and a comprehensive library of H2A and H2B residue substitutions, and identified H2A residues that are required for H2B K123ub. …”

A Localized Chimeric Hydrogel Therapy Combats Tumor Progression through Alteration of Sphingolipid Metabolism by Sanjay Pal (4251406)

“…Therefore, targeting these processes using localized delivery of a minimally toxic drug combination may be a promising strategy. …”

Data_Sheet_1_Effect of far-infrared radiation therapy on von Willebrand factor in patients with chronic kidney disease.docx by Cheng-Chieh Yen (279691)

“…</p>Results<p>A decreasing trend in the vWF activity-antigen ratio of participants in all groups following a single FIR session was observed. …”

<i>A</i>. <i>fumigatus</i> siderophores protect <i>A</i>. <i>fumigatus</i> biofilm from <i>P</i>. <i>aeruginosa</i> anti-fungal activity. by Gabriele Sass (335744)

“…<p>A: Planktonic supernatants produced by an <i>A</i>. …”

Febuxostat ameliorates secondary progressive experimental autoimmune encephalomyelitis by restoring mitochondrial energy production in a GOT2-dependent manner by Josephe A. Honorat (339574)

“…We previously showed that febuxostat, a xanthine oxidase inhibitor, ameliorated both relapsing-remitting and secondary progressive experimental autoimmune encephalomyelitis (EAE) by preventing neurodegeneration in mice. …”

Gene expression and metabolite profiling of gibberellin biosynthesis during induction of somatic embryogenesis in <i>Medicago truncatula</i> Gaertn by Rafał Igielski (4281487)

“…In this study we show that during three week- long induction phase, when cells of leaf explants from non-embryogenic genotype (M9) and embryogenic variant (M9-10a) were forming the callus, all the bioactive gibberellins from non-13-hydroxylation (GA₄, GA₇) and 13-hydroxylation (GA₁, GA₅, GA₃, GA₆) pathways were present, but the contents of only a few of them differed between the tested lines. …”

A Localized Chimeric Hydrogel Therapy Combats Tumor Progression through Alteration of Sphingolipid Metabolism by Sanjay Pal (4251406)

“…Therefore, targeting these processes using localized delivery of a minimally toxic drug combination may be a promising strategy. …”

Dynamic Modelling of Pathways to Cellular Senescence Reveals Strategies for Targeted Interventions by Piero Dalle Pezze (622889)

“…<div><p>Cellular senescence, a state of irreversible cell cycle arrest, is thought to help protect an organism from cancer, yet also contributes to ageing. …”

A Localized Chimeric Hydrogel Therapy Combats Tumor Progression through Alteration of Sphingolipid Metabolism by Sanjay Pal (4251406)

“…Therefore, targeting these processes using localized delivery of a minimally toxic drug combination may be a promising strategy. …”