Ptch1 Inhibits Smo Intercellularly by Maarten F Bijlsma (380371)

“…Shown are RLU values corrected for an internal CMV Renilla luciferase control, expressed as percent differences relative to control-transfected donor cells (vector DNA or scrambled control siRNA). ( <i>n</i> ≥ 4; *, <i>p</i> < 0.05; ***, <i>p</i> < 0.005). Depicted is the mean ± SEM. </p> <p>(B) Fusion of reporter cells with Ptch1 overexpressing donor cells showed a decrease in Gli reporter activity comparable in magnitude to the inhibition observed in mixed cells. …”

Audio_1_Talking to Cows: Reactions to Different Auditory Stimuli During Gentle Human-Animal Interactions.WAV by Annika Lange (9522665)

“…The predicted decrease in HR during stroking was not confirmed; instead we found a slightly increased mean HR during stroking with a subsequent decrease in HR, which was stronger after stroking with live talking. …”

Diagnostic and prognostic role of platelets in patients with sepsis and septic shock by Tobias Schupp (13980761)

“…During the course of sepsis, a nadir was observed on sepsis day 5 with a decrease in the mean platelet count by 21.5%. …”

miRNA-524-5p was target of nifedipine and regulated the expression of BRI3. by Dong-Qing Guo (667396)

“…<p>a) Predicted duplex formation between human BRI3 3′-UTR (top) and three miRNA (bottom) including has-miRNA-524-5p, hsa-miR-1224-3p, hsa-miR-1229 by using TargetScan software. b) The expression of miRNA-524-5p decreased in the MDA-MB-231 cells treated with nifedipine for different periods. …”

Summary of model fit measures. by David D. Ackerly (89663)

“…Next seven rows show models with one factor at a time removed, sorted by decreasing ∆BIC. Last two rows show models with only the climate factors, or only the fixed factors. …”

SCD1 dynamics are altered in response to RSV. by Cristina Rojas (667363)

“…<b>E</b>) SCD1 silencing promotes a slight increase of CHOP expression. The results are shown as the mean of the fold change ± SD of three independent experiments.…”

Accelerated drug action with 3D HD-MEA compared to planar HD-MEA. by Lisa Mapelli (416979)

“…<p>To test the effectiveness of drug perfusion, TTX was applied to acute cerebellar slices. A) Examples of electrical activity maps showing the distribution of active electrodes before (<i><i>top</i></i>) and after TTX application (<i><i>bottom</i></i>) in a slice placed on a 3D chip (color scale bar: 0-300 µV). …”

Proteasome inhibition increases eIF2α phosphorylation and represses translation of EXOC7, TC10 and EXOC1. by Milly M. Choy (790882)

“…(C) Using flow cytometry, the mean fluorescence intensity of EXOC7 and TC10 decreased significantly i7n β-lactone treated infected cells compared to DMSO treated infected cells, indicating a decrease in the protein levels of EXOC7 and TC10 after β-lactone treatment. …”

Latency varies across water conditions. by Mallory E. Udell (11302100)

“…As water temperature is decreased, latency is lengthened. Linear regression indicated that temperature explains 63% of the variance in latency when tested between 47–50°C with the water mixing at a constant, low speed. …”

Hybrid Hydrological Model for Water Flow Prediction in the Piracicaba River Basin-MG, Brazil by Eduardo Morgan Uliana (4895203)

“…<p></p><p>Abstract The association of conceptual hydrological models and artificial neural networks (ANNs) characterizes a hybrid conformation that represents simultaneously conceptual and non-linear processes related to water flow. …”

Change in Allosteric Network Affects Binding Affinities of PDZ Domains: Analysis through Perturbation Response Scanning by Z. Nevin Gerek (174461)

“…One solution to this problem is to explore the dynamics of PDZs, which may provide insights about how intramolecular communication occurs within a single domain. Here, we develop an advancement of perturbation response scanning (PRS) that couples elastic network models with linear response theory (LRT) to predict key residues in allosteric transitions of the two most studied PDZs (PSD-95 PDZ3 domain and hPTP1E PDZ2 domain). …”

The behavioral and electrophysiological effects of parietal alpha tACS in Experiment 2. by Xueli Chen (400644)

“…<p><b>(A)</b> When compared to in-phase tACS, anti-phase tACS significantly suppressed WM performance (i.e., RCS) in 7-letter trials and showed a tendency to decrease WM performance in 5-letter trials. …”

Data Sheet 1_Antimony-resistant PGPR mitigates Sb toxicity and accumulation in peppers by restructuring rhizosphere microorganisms.docx by Xiangquan Sheng (22345987)

“…Microbiota analysis revealed that inoculation enriched stress-responsive bacterial phyla, such as Proteobacteria and Actinobacteria, as well as key functional genera associated with Sb tolerance (e.g., Ramlibacter) and nutrient cycling (e.g., Nitrospira), despite a decrease in alpha-diversity. Co-occurrence networks analysis indicated that inoculation significantly enhance node connectivity and mean degree in rhizosphere bacterial networks, reflecting an increase in structural complexity, especially under severe Sb stress (1,000 mg/kg). …”

Telomerase mutant zebrafish have shorter telomeres than WT siblings. by Catarina M. Henriques (102294)

“…D) TRF mean sizes were calculated as described in <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003214#pgen.1003214-Kimura1" target="_blank">[50]</a>. …”

ST266 attenuates RGC loss in mice with mild-moderate EAE optic neuritis. by Keirnan Willett (9946075)

“…(a) The average normalized RGC count across the entire retina shows a decrease in RGC numbers in vehicle-treated EAE mouse eyes (n = 22 eyes) compared to eyes from non-EAE control mice (n = 44 eyes) (*p<0.05). …”

Down-regulation of STC1 promoted CaSki cells growth and invasion. by Fengjie Guo (277623)

“…(B) MTT assays showed that the effect of decreased STC1 on CaSki cell growth. Following a 7-day period, the growth of CaSki/siRNA cells was much faster than CaSki/NC cells (*<i>p</i><0.05). …”

Mitochondrial fatty acid uptake and complex IV inhibition by palmitoylcarnitine in early type-2 diabetic hearts. by Phing-How Lou (198977)

“…N = 5–6 hearts per group. Data are or mean ± SD (panels A) or mean ± SEM (panel B).</p>…”

Atenolol prevents the formation of expansive hematoma after rhytidoplasty by Amanda Castilho Moreira (12719135)

“…There were four cases of expansive hematoma in group B, all requiring reoperation for drainage, and none in group A (p d" 0,001).Conclusion: The perioperative use of atenolol caused a decrease in blood pressure and heart rate and decreased the incidence of expanding hematoma after rhytidectomy.…”

Cytoplasmic osmolarity profile and transport fluxes under varying external osmotic and pressure conditions. by Yufei Wu (3625967)

“…<p>(a)–(b) Cytoplasmic solute concentration (osmolarity) profile when external osmolarity and pressures conditions are varied. …”

Data Sheet 1_Longitudinal changes in bodyweight, body condition, and muscle condition in ageing pet cats: findings from the Cat Prospective Ageing and Welfare Study.docx by Christine R. Pye (22118977)

“…All three metrics showed significant non-linear associations with age. Bodyweight increased slightly from age 7 to 10 (estimated marginal mean 4.77–4.82 kg) before decreasing to 4.30 kg by age 16 years. …”