CRP-Cyclic AMP Regulates the Expression of Type 3 Fimbriae via Cyclic di-GMP in <i>Klebsiella pneumoniae</i> by Ching-Ting Lin (213761)

“…MrkA production was markedly increased by <i>cyaA</i> or <i>crp</i> deletion, but slightly decreased by <i>cpdA</i> deletion. …”

CNP are toxic to tumor cells but not to normal cells. by Elif Aplak (7430123)

“…B and C, CNP (96 h) dose-dependently decreased cell viability in A375 malignant melanoma cells, but not in normal human epidermal melanocytes (NHEM), measured with the MTT (B) or SRB (C) assay. …”

Neutrophils attenuate inflammatory pain by local opioid peptide release. by Heike L. Rittner (265905)

“…<p>[A] In a rat model, inflammation was induced by intraplantar injection of heat-inactivated <i>Mycobacterium butyricum</i> (complete Freund's adjuvant). …”

Effect of down-regulated NNMT on cytochrome c releasing and caspase processing. by Jun Zhang (48506)

“…(B) and (D) shows the protein quantification of the western blot results shown in (A) and (C), respectively. Cyt c in cytosolic compartment was significantly increased, while the amount of mitochondrial Cyt c was significantly decreased in both cell lines infected with NNMT shRNA 1# and shRNA 2# compared to negative control. …”

Longer crop cycle lengths could offset the negative effects of climate change on Brazilian maize by Tamires Teles de Souza (8141430)

“…We found the air temperature rise as the main factor for yield decreasing, and this finding provides an adaptation option to cope with future climate, as the country has a great latitudinal range for crop management, meaning genotypes with extended cycles could compensate the climate change, and thereby avoid the yield loss for maize crops.…”

Effect of age on the severity of chronic lithium poisoning by B. S. Chan (8462751)

“…Increased severity of lithium toxicity in the elderly is largely explainable by decreased lithium clearance from multiple factors such as age-related decline in renal function, drug interactions and infection.…”

Cerebellar nitrate/nitrite measurements after repeated ZL006 (10 mg/kg) injections (24 h, 19 h, and 1 h prior to decapitation) in Flinders Sensitive Line rats. by Sandra Tillmann (4330477)

“…<p><b>A</b>: Total nitrate/nitrite concentrations were decreased in rats treated with ZL006 compared to vehicle, *: <i>p ≤</i> .05. …”

Effects of metal ions on caspase-1 activation and interleukin-1β release in murine bone marrow-derived macrophages by Maxime-Alexandre Ferko (5679539)

“…<div><p>Ions released from metal implants have been associated with adverse tissue reactions and are therefore a major concern. Studies with macrophages have shown that cobalt, chromium, and nickel ions can activate the NLRP3 inflammasome, a multiprotein complex responsible for the activation of caspase-1 (a proteolytic enzyme converting pro-interleukin [IL]-1β to mature IL-1β). …”

Primary and secondary screenings identify several molecules affecting the synchrony index of MIN6 cells. by Sabine Bavamian (148288)

“…<p>(<i>A</i>) The primary screening of 1040 compounds revealed that several molecules increased or decreased the synchrony index. …”

Ectopic BIR efficiency in translocated strains where the distance between the BIR initiating loci and the telomere was modified. by Tannia Uribe-Calvillo (12902576)

“…The WT values are the same in the two graphs and represent the means of 49 independent experiments. Values for the translocated strains represent the means of three independent experiments. …”

Effects of knockdown (KD) on enhancer activity of the BAC-5.4kb genome sequence encompassing <i>Start</i>. by Kai Otsuka (10507952)

“…Each value was normalized to that of <i>Renilla</i> luciferase activity, which was derived from a co-transfected construct. Data are presented as means ± S.D. from six independent experiments. …”

Representative graphs of temporal pattern of expression for each group of chemokines: Four different temporal patterns of expression were noticed, and the chemokines were grouped a... by Pavlos Vlachogiannis (12289810)

“…<p>Representative graphs for each chemokine group are illustrated with their means and 0.95 CI for each day. More specifically, CCL4 is shown for Group A with its early peak and decreasing trend; CCL28 was the only chemokine of Group B with a significant middle peak on day 4; CXCL6 with its increasing trend and late peak is shown for Group C; and finally, CCL2 is representing Group D with stable values throughout the observation period. …”

JMJD2B stimulates differentiation of 3T3-L1 preadipocytes. by Min-Kyung Jang (3111393)

“…<p>(A) Knockdown of JMJD2B decreased differentiation of 3T3-L1 preadipocytes. …”

Fig 1 - by Adrianne N. Edwards (5646344)

“…The means and standard deviation of three independent biological replicates (A) or standard error of the means of four independent biological replicates (C) are shown. *, P < 0.01 by a Student’s <i>t-</i>test. …”

Transcriptional activity of the MR is attenuated by MS-275 but not MC1568. by Hae-Ahm Lee (787353)

“…Treatment with Aldo resulted in increased expression of <i>GILZ</i> (A) and <i>SGK-1</i> (B), which was decreased by MS-275 but not by MC1568. …”

Analysis of apoptosis and protein changes in human PDL cells under pathological cyclic strain. by Li Wang (15202)

“…Western blot analysis of RhoGDIα, caspase-3, and PARP protein levels. (a) Exposure to cyclic stretch correlates with increased levels of cleaved 19-kDa caspase-3 and 85-kDa PARP; the levels of 32-kDa procaspase-3 and 116-kDa PARP proteins remained unchanged, and the RhoGDIα level decreased. …”

Immediate and Heterogeneous Response of the LiaFSR Two-Component System of <em>Bacillus subtilis</em> to the Peptide Antibiotic Bacitracin by Sara Kesel (104013)

“…<div><h3>Background</h3><p>Two-component signal transduction systems are one means of bacteria to respond to external stimuli. …”

Fluorescent Peptide Biosensor for Probing the Relative Abundance of Cyclin-Dependent Kinases in Living Cells by Laetitia Kurzawa (201196)

“…This peptide biosensor technology affords direct and sensitive readout of CDK/cyclin complex levels, and reports on differences in complex formation when tampering with a single CDK or cyclin. CDKSENS further allows for detection of differences between different healthy and cancer cell lines, thereby enabling to distinguish cells that express high levels of these heterodimeric kinases, from cells that present decreased or defective assemblies. …”

Examples of NF-68 expression (arrows in B-G) in the MGN (B-D) and MoDG of the hippocampus (E-G) from the NC (B and E), 21D-B (C and F) and 21D-B/T (D and G) cohorts. by Xiaoping Du (284656)

“…Error bars represent standard error of the means. Scale bar = 50 µm in G for B-G, = 500 µm in A.…”

TLR4 deficiency diminished glomerular injury in DN. by Jin Ma (335456)

“…<p>WT diabetic mice showed significant glomerular injury including increased kidney to body weight ratio (A), glomerular volume (B), glomerular cellularity (C, week 24), glomerular mesangial matrix (D & E), decreased podocin staining (F) and WT1⁺ podocyte numbers (H & I) compared to non-diabetic WT controls. …”