BBS1 protein interacts with the LRb and regulates its trafficking to the cells surface. by Deng-Fu Guo (2541508)

“…(D-E) Silencing of BBS2, another BBSome protein, lowers the surface levels of Flag-LRb, but not HA-LRa or endogenous TrR in HEK 293 cells (n = 6 per group). (F–G) Blockade of Rab8a using a dominant negative (DN) form decreases the surface expression of Flag-LRb, HA-LRa and endogenous TrR in HEK 293 cells (n = 6 per group). …”

Pre-Existing T- and B-Cell Defects in One Progressive Multifocal Leukoencephalopathy Patient by Alessandra Sottini (173332)

“…The data were compared to those of untreated and natalizumab-treated MS patients and healthy donors. Before therapy, a patient who developed PML had a low TREC and KREC number; TRECs remained low, while KRECs and pre-B lymphocyte gene 1 transcripts peaked at 6 months of therapy and then decreased at PML diagnosis. …”

Spontaneous replay switches between multiple environments. by Bastian Pietras (14295598)

“…<p>In the (A) mesoscopic and (B) microscopic ring-attractor network storing multiple environments, metastable replay dynamics spontaneously emerge due to finite-size fluctuations when decreasing the population size from <i>N</i> = 500 (orange/red in panels i) to <i>N</i> = 50 (blue/black) per unit. …”

Updating representation of position by betasort on an incorrect trial by Greg Jensen (712648)

“…The initial conditions show the beta distributions of a well-learned list, with means labeled with a vertical line. …”

Long-term effect of soil and water conservation measures on runoff, sediment and their relationship in an orchard on sloping red soil of southern China by Anguo Tu (5729024)

“…The results showed that the first 4 years was the key period to prevent soil erosion for this orchard, and then the intensity of soil erosion decreased below 500 t·km^–2·a^–1. …”

Massively parallel unsupervised single-particle cryo-EM data clustering via statistical manifold learning by Jiayi Wu (621314)

“…However, traditional algorithms for unsupervised classification, such as K-means clustering and maximum likelihood optimization, may classify images into wrong classes with decreasing signal-to-noise-ratio (SNR) in the image data, yet demand increased computational costs. …”

uORFs overlapping CDS mediate the highest repressive potential. by Philipp Fervers (5616980)

“…The regression lines slope can be employed as a measure, how effective overweighting a uORF correlates to protein output control. …”

Nanotargeted Delivery of Immune Therapeutics in Type 1 Diabetes by Jung, Sungwook

“…This effect is associated with a significant reduction of T effector cell populations in the PLNs and a decreased production of pro-inflammatory cytokine in the mice treated with MECA79-anti-CD3-NPs. …”
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Image_1_Effects of Interfaces of Goethite and Humic Acid-Goethite Complex on Microbial Degradation of Methyl Parathion.PDF by Gang Zhao (161405)

“…The combined effect would lead to decreased mass fluxes of MP to bacterial cells and could represent another mechanism responsible for the decreased degradation rate observed in the current study.…”

Salicylic Acid Derivatives Inhibit Oxalate Production in Mouse Hepatocytes with Primary Hyperoxaluria Type 1 by María Dolores Moya-Garzón (5597540)

“…We introduce here an unprecedented activity of salicylic acid derivatives as agents capable of decreasing oxalate output in hyperoxaluric hepatocytes at the low micromolar range, which means a potential use in the treatment of PH1. …”

Salicylic Acid Derivatives Inhibit Oxalate Production in Mouse Hepatocytes with Primary Hyperoxaluria Type 1 by María Dolores Moya-Garzón (5597540)

“…We introduce here an unprecedented activity of salicylic acid derivatives as agents capable of decreasing oxalate output in hyperoxaluric hepatocytes at the low micromolar range, which means a potential use in the treatment of PH1. …”

Image1_Using statistical parametric mapping to assess the association of duty factor and step frequency on running kinetic.pdf by Aurélien Patoz (10898784)

“…Both lower DF and SF led to larger vertical and fore-aft ground reaction force fluctuations, but to a lower extent for SF than for DF. Besides, the linearity of the force-length relationship during the leg compression decreased with increasing DF or with decreasing SF but did not change during the leg decompression. …”

Image1_Using statistical parametric mapping to assess the association of duty factor and step frequency on running kinetic.pdf by Aurélien Patoz (10898784)

“…Both lower DF and SF led to larger vertical and fore-aft ground reaction force fluctuations, but to a lower extent for SF than for DF. Besides, the linearity of the force-length relationship during the leg compression decreased with increasing DF or with decreasing SF but did not change during the leg decompression. …”

Conditional targeting of c-Kit in adult mice results in hematopoietic failures at steady state conditions. by Yuki Kimura (199693)

“…<p>(A) c-Kit deficiency leads to impaired hematopoiesis under steady state conditions. …”

Video_2_Automated in vivo Tracking of Cortical Oligodendrocytes.MP4 by Yu Kang T. Xu (8911391)

“…Volumetric data provided by this analysis revealed that oligodendrocyte soma size progressively decreases after their generation, and declines further prior to death, providing a means to predict cell age and eventual cell death from individual time points. …”

Neutrophil Membrane-Derived Nanovesicles Alleviate Inflammation To Protect Mouse Brain Injury from Ischemic Stroke by Xinyue Dong (6268559)

“…Reperfusion to an ischemic brain is a means to reverse brain damage after stroke; however, this causes secondary tissue damage induced by inflammation responses, called ischemia/reperfusion (I/R) injury. …”

Retinoic acid reduces human neuroblastoma cell migration and invasiveness: effects on DCX, LIS1, neurofilaments-68 and vimentin expression-4 by Elio Messi (87833)

“…After 2 or 4 days of RA treatment DCX levels are significantly decreased, but to a lesser extent than after a 6 days exposure to RA. …”

Evidence that Sp1 contributes to the feedback regulation of energy restriction-induced β-TrCP accumulation via Skp2 repression. by Shuo Wei (303184)

“…Columns, means (n = 3); bars, S.D. (E) Schematic diagram depicting a novel Skp2-β-TrCP-Sp1 regulatory loop downstream of Sirt1-mediated downregulation of Csn5 in response to energy restriction, culminating in accentuated upregulation of β-TrCP-mediated apoptosis signaling.…”

Effect of hypoxia on chemotherapeutic agents-induced cell death. by Audrey Sermeus (37122)

“…A light grey cell indicates that hypoxia decreases drug-induced cell death; a dark grey cell indicates that hypoxia does not modify drug-induced cell death; and a black cell indicates that hypoxia aggravates drug-induced cell death. …”

Neutrophil Membrane-Derived Nanovesicles Alleviate Inflammation To Protect Mouse Brain Injury from Ischemic Stroke by Xinyue Dong (6268559)

“…Reperfusion to an ischemic brain is a means to reverse brain damage after stroke; however, this causes secondary tissue damage induced by inflammation responses, called ischemia/reperfusion (I/R) injury. …”