<i>In vitro</i> blocking effect of PD-1-PD-L1 interactions on the effector T cell functions and survival among PTB patients. by Amar Singh (134922)

“…Lymphocytes were gated based on their scatter (FSC/SSC) profile and further gated on CD3⁺ T cells. (<b>A</b>) Representative FACS plots shows production of IFN-γ by CD3⁺ T cells which markedly increases upon blocking PD-1-PD-L1 interaction (<b>B</b>) Each histogram depicts the effect of PD-1, PD-L1 blocking on the percentage of IFN-γ⁺ CD3⁺ T cells (mean ± S.E.M. for n = 8). …”

Table_1_Transcriptomic and Epigenomic Dynamics of Honey Bees in Response to Lethal Viral Infection.XLSX by Hongmei Li-Byarlay (5227208)

“…Israeli Acute Paralysis Virus (IAPV) is emerging as a model virus since its association with severe colony losses. …”

DataSheet_1_Associations between disrupted functional brain network topology and cognitive impairment in patients with rectal cancer during chemotherapy.docx by Yesong Guo (13108692)

“…The functional brain network had preserved small-world topological features but with a tendency towards higher path length in the whole network. …”

Image_2_An in vitro Model of Human Retinal Detachment Reveals Successive Death Pathway Activations.tif by Jelena Potic (9693587)

“…Almost no Cleaved-Caspase3 signal was observed, whereas a transient augmentation at day 3 of AIF-positive cells was observed to be about 10-fold in comparison to the control group (n = 2). …”

Image 2_N1-methylnicotinamide promotes age-related cochlear damage via the overexpression of SIRT1.tif by Toru Miwa (8528715)

“…<p>Age-related hearing loss (ARHL) is a complex condition with genetic, aging, and environmental influences. …”

DataSheet3_Guanxinkang Decoction Attenuates the Inflammation in Atherosclerosis by Regulating Efferocytosis and MAPKs Signaling Pathway in LDLR−/− Mice and RAW264.7 Cells.ZIP by Yifan Zhang (119570)

“…<p>Guanxinkang decoction (GXK), a traditional Chinese medicinal drug, is used to treat cardiovascular disease. …”

Image_1.TIF by Wei-Di He (4920472)

“…To investigate the early cold stress response of Dajiao, here we applied comparative membrane proteomics analysis for both cold-sensitive Cavendish and cold-tolerant Dajiao bananas subjected to cold stress at 10°C for 0, 3, and 6 h. A total of 2,333 and 1,834 proteins were identified in Cavendish and Dajiao, respectively. …”

Table_1_Preliminary prediction of semen quality based on modifiable lifestyle factors by using the XGBoost algorithm.docx by Mingjuan Zhou (12880019)

“…Then, machine learning with the XGBoost algorithm was applied to establish a primary prediction model by using the collected data. …”

Table_4_Additional prognostic value of polymorphisms within the 3′-untranslated region of programmed cell death pathway genes in early-stage breast cancer.docx by Hanxi Chen (11578225)

“…</p>Methods<p>In this study, we genotyped 28 potentially functional single nucleotide polymorphisms (SNPs) in 23 PCD pathway genes in 1,177 patients with early-stage breast cancer (EBC) from a Han Chinese population. The median follow-up period was 174 months.…”

Table_1_Exosome Component 4 Promotes Epithelial Ovarian Cancer Cell Proliferation, Migration, and Invasion via the Wnt Pathway.xlsx by Chang Xiong (11331110)

“…EXOSC4 is expected to be a novel biomarker and molecular target in EOC.</p>…”

Data_Sheet_1_Genome-Wide Analysis of the Soybean TIFY Family and Identification of GmTIFY10e and GmTIFY10g Response to Salt Stress.docx by Ya-Li Liu (530354)

“…Further analysis demonstrated that GmTIFY10e and GmTIFY10g genes changed the expression levels of genes related to the ABA signal pathway, including GmSnRK2, GmPP2C, GmMYC2, GmCAT1, and GmPOD. This study provides a basis for comprehensive analysis of the role of soybean TIFY genes in stress response in the future.…”

Table 1_Enterococcus faecalis strains derived from wild bird provide protection against Clostridium perfringens challenge in locally-sourced broilers.docx by Gerui Zhang (17630411)

“…Introduction<p>Necrotic enteritis (NE), caused by Clostridium perfringens, has seen a surge in chicken populations recently due to the ban on antibiotic growth promoters in feed.…”

Data_Sheet_2_Molecular Signatures of Neuroinflammation Induced by αSynuclein Aggregates in Microglial Cells.xlsx by Souvarish Sarkar (8382513)

“…We validated progranulin (PGRN) as a lysosomal PD-associated protein that is downregulated by αSyn_Agg in microglia in-vivo and is expressed by microglia in post-mortem PD brain, congruent with our in vitro findings.…”

Data Sheet 1_Diagnostic classification of mild cognitive impairment in Parkinson's disease using subject-level stratified machine-learning analysis.pdf by Jing Wang (6206297)

“…Background<p>The timely identification of mild cognitive impairment (MCI) in Parkinson's disease (PD) is essential for early intervention and clinical management, yet it remains a challenge in practice.</p>Methods<p>We conducted an analysis of 3,154 clinical visits from 896 participants in the Parkinson's Progression Markers Initiative (PPMI) cohort. …”

Dendritic Cells from Crohn’s Disease Patients Show Aberrant STAT1 and STAT3 Signaling by Janne K. Nieminen (442997)

“…Studies on JAK/STAT signaling in DCs are, however, lacking in CD. We applied a flowcytometric single-cell-based phosphoepitope assay to evaluate STAT1 and STAT3 pathways in DC subsets from CD patients. …”

Data_Sheet_1_Liuwei Dihuang Decoction Alleviates Cognitive Dysfunction in Mice With D-Galactose-Induced Aging by Regulating Lipid Metabolism and Oxidative Stress via the Microbiota... by Baiyan Liu (12869393)

“…Liuwei Dihuang decoction (LW), a commonly applied Chinese medicine formula, is widely used for the treatment of aging-related diseases in China. …”

Data_Sheet_2_Mendelian randomization in blood metabolites identifies triglycerides and fatty acids saturation level as associated traits linked to pancreatitis risk.PDF by Jiarui Mi (11170284)

“…</p>Results<p>In the primary analysis with 249 traits, we found that plasma triglycerides were positively associated with pancreatitis risk. Intriguingly, a large number of traits associated with saturation or unsaturation of fatty acids also demonstrated causal associations. …”

Video_3_Advanced Microscopy Reveals Complex Developmental and Subcellular Localization Patterns of ANNEXIN 1 in Arabidopsis.mp4 by Michaela Tichá (9207320)

“…Massive relocation and accumulation of ANN1-GFP at the PM and in Hechtian strands and reticulum in plasmolyzed cells suggest a possible osmoprotective role of ANN1-GFP during plasmolysis/deplasmolysis cycle. …”

DataSheet_1_microRNA-145-5p inhibits prostate cancer bone metastatic by modulating the epithelial-mesenchymal transition.csv by Bingfeng Luo (13718917)

“…Mimicry of miRNA-145-5p action raises the possibility of a novel target for treating Pca with bone metastases.…”

DataSheet_1_Additional prognostic value of polymorphisms within the 3′-untranslated region of programmed cell death pathway genes in early-stage breast cancer.pdf by Hanxi Chen (11578225)

“…</p>Methods<p>In this study, we genotyped 28 potentially functional single nucleotide polymorphisms (SNPs) in 23 PCD pathway genes in 1,177 patients with early-stage breast cancer (EBC) from a Han Chinese population. The median follow-up period was 174 months.…”