Cytochrome P450 3A1 Mediates 2,2′,4,4′-Tetrabromodiphenyl Ether-Induced Reduction of Spermatogenesis in Adult Rats by Zhan Zhang (215106)

“…Additionally, testicular 3-OH-BDE47 and reactive oxygen species (ROS) in seminiferous tubules increased especially when BDE47 was administered in combination with DEX, which was confirmed in GC-1 and GC-2 cells that 3-OH-BDE47 induced more ROS production and cell apoptosis via the upregulation of FAS/FASL, p-p53 and caspase 3. As a result, daily sperm production dose-dependently decreased, consistent with histological observations in giant cells and vacuolar spaces and increase in TUNEL-positive apoptotic germ cells.…”

Association between the posterior part of the circle of Willis and the vertebral artery hypoplasia by Virginija Gaigalaite (7378229)

“…With the increasing degree of VAH, the proportion of FCW increases, while the proportion of absence/hypoplastic of both PCoA decreases.</p></div>…”

Image1_Comprehensive Analysis of Expression and Prognostic Value of MS4As in Glioma.TIFF by Yingying Zeng (2122864)

“…<p>Glioma is the most common malignancy of the nervous system with high mortality rates. The MS4A family members have been reported as potential prognostic biomarkers in several cancers; however, the relationship between the MS4A family and glioma has not been clearly confirmed. …”

Image_2_RhoA Drives T-Cell Activation and Encephalitogenic Potential in an Animal Model of Multiple Sclerosis.JPEG by Alba Manresa-Arraut (5318861)

“…Besides presenting reduced migratory capacity, both naïve and autoreactive effector T-cells from RhoA^fl/flLckCre⁺ mice show decreased viability, proliferative capacity, and an activation profile associated with reduced production of Th1 pro-inflammatory cytokines. …”

Image_1_RhoA Drives T-Cell Activation and Encephalitogenic Potential in an Animal Model of Multiple Sclerosis.JPEG by Alba Manresa-Arraut (5318861)

“…Besides presenting reduced migratory capacity, both naïve and autoreactive effector T-cells from RhoA^fl/flLckCre⁺ mice show decreased viability, proliferative capacity, and an activation profile associated with reduced production of Th1 pro-inflammatory cytokines. …”

Table_3_The N6-Methyladenosine Features of mRNA and Aberrant Expression of m6A Modified Genes in Gastric Cancer and Their Potential Impact on the Risk and Prognosis.XLS by Liang Sang (6525962)

“…The genes with higher levels of m6A in their mRNAs were mainly enriched in transcriptional misregulation in carcinogenesis pathways, whereas the genes with decreased methylation mainly regulated digestion and absorption of protein. …”

Table_4_The N6-Methyladenosine Features of mRNA and Aberrant Expression of m6A Modified Genes in Gastric Cancer and Their Potential Impact on the Risk and Prognosis.XLSX by Liang Sang (6525962)

“…The genes with higher levels of m6A in their mRNAs were mainly enriched in transcriptional misregulation in carcinogenesis pathways, whereas the genes with decreased methylation mainly regulated digestion and absorption of protein. …”

Table_1_The N6-Methyladenosine Features of mRNA and Aberrant Expression of m6A Modified Genes in Gastric Cancer and Their Potential Impact on the Risk and Prognosis.XLSX by Liang Sang (6525962)

“…The genes with higher levels of m6A in their mRNAs were mainly enriched in transcriptional misregulation in carcinogenesis pathways, whereas the genes with decreased methylation mainly regulated digestion and absorption of protein. …”

Image_4_RhoA Drives T-Cell Activation and Encephalitogenic Potential in an Animal Model of Multiple Sclerosis.JPEG by Alba Manresa-Arraut (5318861)

“…Besides presenting reduced migratory capacity, both naïve and autoreactive effector T-cells from RhoA^fl/flLckCre⁺ mice show decreased viability, proliferative capacity, and an activation profile associated with reduced production of Th1 pro-inflammatory cytokines. …”

Data_Sheet_1_Histone Modifications Drive Aberrant Notch3 Expression/Activity and Growth in T-ALL.pdf by Luca Tottone (6548468)

“…Consistently, pharmacological inhibition of JMJD3 by GSKJ4 treatment or of p300 by A-485 decreased the levels of expression of NOTCH3, NOTCH1 and of the Notch target genes DELTEX1 and c-Myc and abrogated cell viability in both Notch1- and Notch3-dependent T-cell contexts. …”

Macrophage content of gonadal white adipose tissue is decreased in female <i>Saa3</i>^−/− mice. by Laura J. den Hartigh (297271)

Knockdown of CTCF restores <i>hTERT</i> expression and decreases apoptosis in SFN-treated breast cancer cells. by Syed M. Meeran (321543)

The Small Molecule Triclabendazole Decreases the Intracellular Level of Cyclic AMP and Increases Resistance to Stress in <i>Saccharomyces cerevisiae</i> by Yong Joo Lee (357685)

“…Evidence is presented that triclabendazole decreases the intracellular level of cyclic AMP by inhibiting adenylyl cyclase and triggers the parallel rapid translocation of the stress-resistance transcription factor Msn2 from the cytosol into the nucleus, as deduced from experiments employing a strain in which <i>MSN2</i> is replaced with <i>MSN2-GFP</i> (GFP, green fluorescent protein). …”

Overexpression of ICAM-1 by lymphocytes and decreased of CD62L⁺ cells from late postmenopausal women. by Nicté Figueroa-Vega (741283)

Panobinostat downregulated Ron mRNA, protein expression and decreased downstream signaling through pAkt, XIAP, and survivin. by Yi Zou (439002)

Number of eggs laid by females is decreased by the presence of <i>NetAB</i> males compared to wild type males. by Gunnar Newquist (446218)

“…<p>(<b>A</b>) Mean number of eggs laid is significantly decreased in wild type females when the male is <i>NetAB</i> (p = 0.0246, Student’s t-test). …”

<i>N</i>-glycans which showed decreased relative abundance in cancer patient serum compared with normal volunteer. by Shih-Yun Guu (755060)

Decreasing the Peril of Antimicrobial Resistance Through Enhanced Health Literacy in Outpatient Settings: An Underrecognized Approach to Advance Antimicrobial Stewardship by Elizabeth D. Hermsen (8085392)

Table_1_Linoleic Acid Inhibits the Release of Leishmania donovani Derived Microvesicles and Decreases Its Survival in Macrophages.DOCX by Sheetal Saini (6560501)

“…<p>Visceral leishmaniasis is a neglected tropical disease caused by Leishmania (L.) donovani parasite in the Indian subcontinent. …”

Down regulation of Nrf2 leads to decreased Mrp1 and sensitized H69AR cells to chemotherapeutic drugs. by Lili Ji (296025)