Structural Insights into the Role of the Stereochemistry of the Cyclopropyl Ring in the Inhibitory Activity of Xeruborbactam against SME‑1 Class A Carbapenemase by Kunal Dhankhar (14586938)

“…Although both inhibitors bind covalently to Ser70 in SME-1, the 2<i>R</i>,3<i>S</i>-isomer adopts a different conformation of the cyclopropyl ring, which makes the C3 carbon much farther from His105, Asn132, and Lys73, thereby decreasing the binding affinity and <i>K</i>_i(app) of the isomer. …”

Illumination distributions (a-c) and variations in illuminance values along the x-axis (d-f) of the RHL at different angles. by Fei Li (143236)

Phenotype and molecular identification of <i>GmNN1/FT2a</i> in stable transgenic soybean plants. by Xinxin Li (281237)

Subjects:

Table 2 - Early identification of the efficacy of 0.125% atropine treatment for children with Myopia: A prospective pilot study by Zi-Rong Chen (9227618)

Baseline demographic and clinical characteristics for patients with PNH and mild/moderate anemia^a in PADDOCK, PRINCE, and PEGASUS. by Jens Panse (350046)

A funnel plot shows the distribution of HIV-related perceived stigma among people living with HIV/AIDS in Africa. by Gebresilassie Tadesse (18069820)

Difference in proportion of lesions correctly identified by young and old cohort of optometrists (A) Performance of subjects with normal color vision. by Richard C. Trevino (22676460)

Mean total cholesterol levels over time in the roxadustat group (A) and ESAs group (B) according to the statins subgroup. by Jie Liu (15128)

Competition experiments between the wild-type strain and the Δ<i>corA</i> mutant of <i>Salmonella</i>. by Selma Metaane (12329248)

Structural Insights into the Role of the Stereochemistry of the Cyclopropyl Ring in the Inhibitory Activity of Xeruborbactam against SME‑1 Class A Carbapenemase by Kunal Dhankhar (14586938)

“…Although both inhibitors bind covalently to Ser70 in SME-1, the 2<i>R</i>,3<i>S</i>-isomer adopts a different conformation of the cyclopropyl ring, which makes the C3 carbon much farther from His105, Asn132, and Lys73, thereby decreasing the binding affinity and <i>K</i>_i(app) of the isomer. …”

PIF4 protein level regulates <i>PIF4</i> promoter activity in a temperature-dependent manner. by Sreya Das (20531295)

(A) Network map of the top ten anti-AD core targets and the top 30 KEGG pathways.... by Shakeel Ahmad Khan (13202394)

“…<p>(A) Network map of the top ten anti-AD core targets and the top 30 KEGG pathways. …”

The percentage (%) of isolates with decreased susceptibility or resistance to extended-spectrum cephalosporin (ESC) (cefixime and/or ceftriaxone) according to the most recent World Health Organization (WHO) Gonococcal Antimicrobial Surveillance Programme (GASP) data (2014 for most countries, but for a few countries, only 2011–2013 data were available). by Teodora Wi (3700879)

Amoxicillin-induced bacterial gut dysbiosis decreases the expression of (A) <i>IL-1</i> <i>β</i> and (B) <i>IL-6</i> but increases the expression of the (C) <i>IL-10</i> gene in the lungs of mice infected with <i>M. bovis</i>-BCG. by Tatimara M. Miyauchi-Tavares (20790494)

Effect of E2A on cell cycle progression. by Ao Huang (508797)

“…<p>(A) Downregulation of E2A in SW480 cells led to an increase of cells at S phase and concomitantly a decrease of cells at G1/G0 phase; (B) Ectopic expression of E12 or E47 increased cells at G1/G0 phase of SW480/shE2A cells and reduced S phase cells. …”

Summary of experimental task trial designs. by Keith A. Bush (5472590)

“…The dashed line represents the trigger threshold and bounds the hyperplane distance at which the cue stimulus will be triggered by the real-time valence estimate as a function of time. As depicted, this threshold decreases linearly to zero commencing at 20 s of feedback. …”

Size of pore width (Px) and pore height (Pz) for scaffolds with different numbers of layers; A1-A2) lattice scaffold, B1-B2) staggered scaffold (Data are presented as M ± SD). by Zahra Yazdanpanah (10038944)

Image 1_Structural and acoustic properties of urbanized landscapes adversely affect bird communities in a tropical environment.tiff by Dickson Anoibi Matthew (20287776)

“…Similarly, species common to all the urbanization categories (species present at least at one point in rural, suburban, and urban) also exhibited a decrease in abundance. The suburban area showed a greater similarity in bird community composition to the urban area than the rural area. …”

Analyzing the effects of integrated care approaches to address co-occurring depression and diabetes: A systematic review and meta-analysis by Zach W Cooper (19688646)

“…Of 26 studies reporting HbA1c, IC approaches were associated with a significant between-group difference regarding the percent decrease of HbA1c (d = -0.36, 95% CI: -0.52 to -0.21). …”

Image_1_Bone Marrow Aspiration Does Not Induce a Measurable Pain Response Compared to Sham Procedure.TIF by Aileen L. Rowland (5806352)

“…No differences were noted between groups in heart rate variability before or during the procedure, but there was a significant decrease in low frequency/high frequency (LF/HF) ratio after the procedure in the BMA group. …”