Cleavage of osmosensitive transcriptional factor NFAT5 by Coxsackieviral protease 2A promotes viral replication by Ye Qiu (363315)

“…In this study, we aimed to understand the mechanism by which NFAT5 interferes with infection of Coxsackievirus B3 (CVB3), a major cause of viral myocarditis. Our initial results demonstrated that although the mRNA level of NFAT5 remained constant during CVB3 infection, NFAT5 protein level decreased because the protein was cleaved. …”

Functional regulatory mechanism of smooth muscle cell-restricted <i>LMOD1</i> coronary artery disease locus by Vivek Nanda (746334)

“…<i>LMOD1</i> knockdown results in increased proliferation and migration and decreased cell contraction in HCASMC, and immunostaining in atherosclerotic lesions in the SMC lineage tracing reporter mouse support a key role for LMOD1 in maintaining the differentiated SMC phenotype. …”

mGluR1 facilitates anchorage-independent growth. by Malathi Banda (505556)

“…<p><b>A and B. MCF10AT1 cells.</b> Cells were transduced with either with pLenti-<i>GRM1</i>, pLenti-<i>LacZ</i>, sh<i>GRM1</i>, or NS control vector and stably selected before plating in soft agar. …”

<i>Mycobacterium tuberculosis</i>-induced miR-155 subverts autophagy by targeting ATG3 in human dendritic cells by Marilena P. Etna (4735113)

“…Late in infection, when miR-155 expression peaked, both the level of Atg3 and the number of LC3 puncta per cell (autophagosomes) decreased dramatically. In accordance, miR-155 silencing rescued autophagosome number in Mtb infected DC and enhanced autolysosome fusion, thereby supporting a previously unidentified role of the miR-155 as inhibitor of ATG3 expression. …”

Mutations in Mtr4 Structural Domains Reveal Their Important Role in Regulating tRNA_i^Met Turnover in <i>Saccharomyces cerevisiae</i> and Mtr4p Enzymatic Activi... by Yan Li (23143)

“…<div><p>RNA processing and turnover play important roles in the maturation, metabolism and quality control of a large variety of RNAs thereby contributing to gene expression and cellular health. …”

The correlation between external apical root resorption and electric pulp test responses: a prospective clinical trial by Farnaz YOUNESSIAN (12853367)

“…Conclusion: The relative decrease in electric pulp test level could be a diagnostic sign of root resorption during orthodontic treatment. …”

Identifying Insects with Incomplete DNA Barcode Libraries, African Fruit Flies (Diptera: Tephritidae) as a Test Case by Massimiliano Virgilio (182967)

“…In all cases, more restrictive distance thresholds produced a gradual increase in the proportion of true negatives, a gradual decrease of false positives and more abrupt variations in the proportions of true positives and false negatives. …”

Purification, characterization, and antitumor activity of a novel glucan from the fruiting bodies of <i>Coriolus Versicolor</i> by Annoor Awadasseid (3726955)

“…Structural analysis revealed that CVG has a linear α-glucan chain composed of only (1→ 6)-α-D-Glc<i>p</i>. …”

Interaction between polymorphisms in aspirin metabolic pathways, regular aspirin use and colorectal cancer risk: A case-control study in unselected white European populations by Harsh Sheth (4843305)

“…Meta-analysis of SNPs rs2070959 and rs1105879 in <i>UGT1A6</i> gene showed interaction between aspirin use and CRC risk (<i>P</i>_interaction = 0.01 and 0.02, respectively); stratification by aspirin use showed an association for decreased CRC risk for aspirin users having a wild-type genotype (rs2070959 OR = 0.77, 95% CI = 0.68–0.86; rs1105879 OR = 0.77 95% CI = 0.69–0.86) compared to variant allele cariers. …”

Inhibition of cAMP-Dependent PKA Activates β₂-Adrenergic Receptor Stimulation of Cytosolic Phospholipase A₂ via Raf-1/MEK/ERK and IP₃-Dependent Ca<... by M. R. Pabbidi (3560993)

“…<div><p>We previously reported in atrial myocytes that inhibition of cAMP-dependent protein kinase (PKA) by laminin (LMN)-integrin signaling activates β₂-adrenergic receptor (β₂-AR) stimulation of cytosolic phospholipase A₂ (cPLA₂). The present study sought to determine the signaling mechanisms by which inhibition of PKA activates β₂-AR stimulation of cPLA₂. …”

In vivo performance of FRCaMPi and SomaFRCaMPi in neurons in zebrafish larvae. by Shihao Zhou (5774795)

“…<b>(B)</b> Representative single plane confocal images of periventricular cell bodies in optic tectum of fish expressing jRGECO1a, FRCaMPi or SomaFRCaMPi. Decreased neuropil fluorescence and clearer neuronal cell bodies was found in SomaFRCaMPi-expressing larval zebrafish. …”

NRG1-II stimulates neurogenesis through ErbB4 as a cell-extrinsic signal. by Tomomi Sato (301255)

“…The approximate site of the section is shown in a lateral view in the inset. <b>E</b>. A decrease in Tyr¹¹⁶²-phosphorylated ErbB4 (pErbB4) in the OT of MO^{<i>nrg1IIE1</i>}-injected embryos (<i>nrg1IIE1</i>) compared to the control MO^{<i>nrg1IIE15m</i>}-injected embryos (<i>nrg1IIE15m</i>) at 40 hpf. …”

MMV291 disrupts actin-dependent apicoplast segregation and induces a partial delayed death phenotype. by Madeline G. Dans (14193815)

“…<b>ii</b> These images were quantified by 3 independent blind scorers, which showed a significant decrease in the normal segregation of apicoplasts between the 10 μM MMV291 and DMSO treatments, while the 5 μM MMV291 was not significant (ns). …”

Knockdown of Appa, Appb, or Prp1 results in impaired development and death of head region. A–L. by Darcy M. Kaiser (114856)

“…S3</a>). The <i>appa</i> and <i>appb</i> splice blocking (SB) MOs used above (A–H) significantly decreases detection of protein species by the antibody 22C11 (top row). …”

A randomized controlled trial and prospective cohort investigating antivenom for red-bellied black snake envenomation by Geoffrey K. Isbister (8281572)

“…</p> <p>Administration of antivenom in red-bellied black snake envenomation within 6 hours post-bite appeared to decrease the proportion of patients with myotoxicity, but a third of patients had adverse reactions.…”

Data_Sheet_1_Life Cycle Dynamics of a Key Marine Species Under Multiple Stressors.PDF by Saskia A. Otto (6717152)

“…As a consequence, we found that a favorable increase of oxygen and phosphate conditions together with a reduction in predation pressure by 50% each could counteract the negative effect of a 25% decrease in salinity by only 6%. …”

The <i>Airn</i> CGI plays a major role in <i>Airn</i> transcription and function. by Martha V. Koerner (180097)

“…(D) ChIP for Ser5P/Ser2P RNAPII in <i>S12/+</i>, <i>S12/TDRΔ</i>-1A and <i>S12/CGIΔ</i>-1A d11 cells shows unaffected <i>Airn</i> initiation and elongation (except at <i>Airn</i>-end) in <i>TDRΔ</i> and a sharp RNAPII decrease in the <i>CGIΔ</i> allele. …”

Chronological changes in the pattern of sessile cells in <i>Drosophila</i> larvae after a wasp infection. by Ines Anderl (611071)

“…Secondary lymph gland lobes were hypertrophied (B”‘-B”“, C”‘-C”“), whereas primary lymph gland lobes were always absent (B”“‘, C”“‘). A <i>L</i>. <i>heterotoma</i> infection led to a decrease in sessile blood cell numbers. …”

Addition of Amines to a Carbonyl Ligand: Syntheses, Characterization, and Reactivities of Iridium(III) Porphyrin Carbamoyl Complexes by Taiwo O. Dairo (1810897)

“…The <i>trans</i>-amine ligand is labile and can be replaced with quinuclidine (1-azabicyclo[2.2.2]­octane, ABCO), 1-methylimidazole (1-MeIm), triethyl phosphite (P­(OEt)₃), and dimethylphenylphosphine (PMe₂Ph) at 23 °C to afford the hexacoordinated carbamoyl complexes (TTP)­Ir­(L)­[C­(O)­NHR] (for R = Bn: L = ABCO (<b>3a</b>), 1-MeIm (<b>4a</b>), P­(OEt)₃ (<b>5a</b>), PMe₂Ph (<b>6a</b>)). …”

A role for <i>bmm</i> function in neurons in the regulation of whole-body triglyceride breakdown in males. by Lianna W. Wat (8339454)

“…(B) There was a significant reduction in whole-body triglyceride levels in 5-day-old <i>elav>+</i> and <i>+>UAS-bmm-RNAi</i> control males between 0 and 12 hours STV (<i>p</i> = 1 × 10⁻⁵ and 9 × 10⁻⁶, respectively; one-way ANOVA followed by Tukey HSD test); however, no significant decrease in triglyceride levels was observed between 0 and 12 hours STV in <i>elav>UAS-bmm-RNAi</i> males (<i>p</i> = 0.13; one-way ANOVA followed by Tukey HSD test). …”