Modelling the Evolutionary Dynamics of Viruses within Their Hosts: A Case Study Using High-Throughput Sequencing by Frédéric Fabre (169769)

“…<div><p>Uncovering how natural selection and genetic drift shape the evolutionary dynamics of virus populations within their hosts can pave the way to a better understanding of virus emergence. Mathematical models already play a leading role in these studies and are intended to predict future emergences. …”

DataSheet_1_Methylation of SPRED1: A New Target in Acute Myeloid Leukemia.docx by Nan Su (323312)

“…<p>Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) has been identified as a novel tumor suppressor gene in acute myeloid leukemia (AML). …”

DataSheet_1_The impact of dietary fibers on Clostridioides difficile infection in a mouse model.docx by Zhengjie Wu (11480984)

“…The pectin group showed a higher abundance of Lachnospiraceae and a lower abundance of the conditionally pathogenic Enterobacteriaceae than the cellulose group with infection. …”

Sensitivity of various GFP insertion constructs (<i>columns A through J</i>) to protein misfolding. by Stéphanie Cabantous (92574)

“…<p>(A) Images of <i>E. coli</i> cells on plates expressing four test fusions proteins with decreasing folding robustness at 37°C. …”

Table_1_Spatial distribution of supratentorial diffuse gliomas: A retrospective study of 990 cases.xlsx by Gen Li (743590)

“…This study aims to describe a more detailed distributing pattern of these tumors with age and pathological factors concerned.…”

Supplementary Material for: Acute interstitial nephritis associated to Pertussis infection: a case report and review of the literature by figshare admin karger (2628495)

“…Case Presentation: A 73-year-old male with a history of systemic arterial hypertension, dyslipidemia, and previous left nephrectomy presented with a five-day history of fatigue, fever, cough, and nasal obstruction. …”

Peripheral CLOCK Regulates Target-Tissue Glucocorticoid Receptor Transcriptional Activity in a Circadian Fashion in Man by Evangelia Charmandari (203778)

“…</p> <h3>Conclusions</h3><p>Peripheral CLOCK-mediated circadian acetylation of the human GR may function as a target-tissue, gene-specific counter regulatory mechanism to the actions of diurnally fluctuating cortisol, effectively decreasing tissue sensitivity to glucocorticoids in the morning and increasing it at night.…”

Table_2_The Development of Evidence-Based Classification of Vision Impairment in Judo: A Delphi Study.DOCX by Kai J. Krabben (6338663)

“…</p><p>Results: The panel expressed that: (i) blind and partially sighted athletes should not compete against each other in the same class; (ii) additional measures of visual function might be needed to accurately evaluate an athlete’s impairment; (iii) the minimum impairment criteria (MIC) should represent a more severe level of impairment to ensure that all those included possess a level of VI that indeed decreases performance in judo; and (iv) legitimate competition could be undermined by some athletes intentionally underperforming on classification tests. …”

Table_1_Sphingolipids as a Culprit of Mitochondrial Dysfunction in Insulin Resistance and Type 2 Diabetes.docx by Kamila Roszczyc-Owsiejczuk (10322705)

“…Adverse effects of sphingolipid accumulation have recently been linked to the activation of protein kinase Cζ (PKCζ) and protein phosphatase 2A (PP2A), which, in turn, negatively affect phosphorylation of serine/threonine kinase Akt [also known as protein kinase B (PKB)], leading to decreased glucose uptake in skeletal muscles as well as increased gluconeogenesis and glycogenolysis in the liver. …”

The first dipeptidyl peptidase III from a thermophile: Structural basis for thermal stability and reduced activity by Igor Sabljić (2807347)

“…<div><p>Dipeptidyl peptidase III (DPP III) isolated from the thermophilic bacteria <i>Caldithrix abyssi</i> (<i>Ca</i>) is a two-domain zinc exopeptidase, a member of the M49 family. …”

Data_Sheet_1_Stuttering in individuals with Down syndrome: a systematic review of earlier research.pdf by Silje Hokstad (10577739)

“…We identified 14 eligible studies, with a total of 1,833 participants (mean = 131.29, standard deviation = 227.85, median = 45.5) between 3 and 58 years of age. …”

Table_1_The Development of Evidence-Based Classification of Vision Impairment in Judo: A Delphi Study.DOCX by Kai J. Krabben (6338663)

“…</p><p>Results: The panel expressed that: (i) blind and partially sighted athletes should not compete against each other in the same class; (ii) additional measures of visual function might be needed to accurately evaluate an athlete’s impairment; (iii) the minimum impairment criteria (MIC) should represent a more severe level of impairment to ensure that all those included possess a level of VI that indeed decreases performance in judo; and (iv) legitimate competition could be undermined by some athletes intentionally underperforming on classification tests. …”

Image_1_Baicalein—A Potent Pro-Homeostatic Regulator of Microglia in Retinal Ischemic Injury.jpeg by Li Pan (49390)

“…<p>Retinal ischemia is a common cause of many retinal diseases, leading to irreversible vision impairment and blindness. …”

Image_2_Circulating fatty acids, genetic susceptibility and hypertension: a prospective cohort study.PDF by Lingling Lu (2589835)

“…Background<p>Combining genetic risk factors and plasma fatty acids (FAs) can be used as an effective method of precision medicine to prevent hypertension risk.</p>Methods<p>A total of 195,250 participants in the UK Biobank cohort were included in this study from 2006–2010. …”

Image1_The light-independent locomotion response to a static magnetic field in Xenopus tadpoles.TIF by Jie Ren (176083)

“…We have previously reported that the physical performance of mice decreased after 1 month of exposure to a hypomagnetic field, which probably includes a light-independent mechanism. …”

An AlphaFold2-based variant effect classification scheme for the CXXC domain of KMT2A. by Tinna Reynisdottir (12902681)

“…The surface of the domain is color-coded based on the electrostatic potential, with red indicating a negative charge and blue a positive charge. Both variants lead to a decreased electrostatic potential in a residue important for DNA binding.…”

Sirtuin 1 Regulates SREBP-1c Expression in a LXR-Dependent Manner in Skeletal Muscle by Aurélia Defour (135815)

“…<div><p>Sirtuin 1 (SIRT1), a NAD⁺-dependent protein deacetylase, has emerged as a main determinant of whole body homeostasis in mammals by regulating a large spectrum of transcriptional regulators in metabolically relevant tissue such as liver, adipose tissue and skeletal muscle. …”

Defect-Induced Band-Edge Reconstruction of a Bismuth-Halide Double Perovskite for Visible-Light Absorption by Adam H. Slavney (1415035)

“…The first halide double perovskite evaluated as an absorber, Cs₂AgBiBr₆ (<b>1</b>), has a bandgap of 1.95 eV. Here, we show that dilute alloying decreases <b>1</b>’s bandgap by ca. 0.5 eV. …”

Table_1_Exploring the role of gut microbiota dysbiosis in gout pathogenesis: a systematic review.DOCX by Salman Shirvani-Rad (15535610)

“…This systematic review aimed to summarize the role of gut dysbiosis in gout disease and uncover the underlying mechanisms.</p>Methods<p>A comprehensive search was conducted on PubMed, Web of Science, and Scopus databases up to October 2021. …”

Evolutionary history predicts the response of tree species to forest loss: A case study in peninsular Spain by Rafael Molina-Venegas (3300951)

“…However, the probability of occurrence of many species increased when forest canopy cover decreased across landscape scales. We detected a strong phylogenetic signal in species response to forest loss at local and small landscape (1.6 km) scales. …”