Development of obesity, liver steatosis, glucose intolerance, and insulin resistance in high fat diet-fed mice. by Mami Shiwa (712070)

Confocal microscopic imaging of degenerated nerve sections after topical application of F-NP41 and control peptide. by Timon Hussain (699574)

Inhibition of p90 ribosomal S6 kinase potentiates cisplatin activity in A549 human lung adenocarcinoma cells by Abdulrahman, Nabeel

“…Methods: Our study examined the effect of cisplatin, BI-D1870 (RSK inhibitor) or their combination on cell migration, apoptosis, autophagy and cell cycle in A549 human lung adenocarcinoma cells. Results: The combination of cisplatin and BI-D1870 potentiated the antimigration rate, the activation of caspases-3 and was associated with a significant decrease in RSK1 and ERK expression when compared to cisplatin alone. …”
Get full text
Get full text

Empirical evaluation of change in crash risk due to lane marking reallocation: A case study in Kochi City, Japan by Hiroaki, Nishiuchi

“…Lane markings are considered an essential component of a road system. As highlighted in previous studies, they are directly linked to efficiency and safety. …”
Get full text
Get full text
Get full text

Investigating the structural impacts of a novel missense variant identified with whole exome sequencing in an Egyptian patient with propionic acidemia by Ibrahim, Ali Zaki

“…Propionic Acidemia (PA) is an inborn error of metabolism caused by variants in the or genes, leading to mitochondrial accumulation of propionyl-CoA and its by-products. Here, we report a 2 year-old Egyptian boy with PA who was born to consanguineous parents. …”
Get full text
Get full text

Ferrocenyl-Imidazolylidene Ligand for Redox-Switchable Gold-Based Catalysis. A Detailed Study on the Redox-Switching Abilities of the Ligand by Susana Ibáñez (1607290)

“…The analysis of the electron-donating character of the neutral ligand and the ligand resulting from the oxidation was carried out by studying the variation of the ν­(CO) stretching frequencies of Fc-NHC-IrCl­(CO)₂ and its oxidized analogue, revealing that this shift is 2.9 cm^–1, which is consistent with a decrease of the electron-donating character of the ligand produced by the generation of a positively charged metal complex. …”

Data Sheet 1_Causal relationship between inflammatory bowel disease and sex: a Mendelian randomization study.pdf by Kaiwen Wang (838527)

“…</p>Results<p>There was no causal relationship between sex hormones and IBD in women (P > 0.05), and there was a causal and positive correlation between SHBG and testosterone and IBD in men.The OR for SHBG was 1.22 (95% CI: 1.09-1.37, P = 0.0004), and for testosterone was 1.20 (95% CI: 1.04-1.39, P = 0.0145).IBD did not significantly interact with female sex hormones but resulted in a decrease in SHBG (OR = 1.02, 95% CI: 1.00-1.04, P = 0.0195) and testosterone (OR = 1.01, 95% CI: 1.00 -1.02, P = 0.0200) in men.…”

Establishment of a neurodegenerating model of primary cerebrocortical cultures: Association of different APP isoforms with glial and neuronal cell types. by Jason A. Bailey (229720)

“…<p><b>A</b>: Cell lysates and conditioned media samples of primary cortical cultures were collected at day 12 and day 20 for Western blot analysis. …”

Ferrocenyl-Imidazolylidene Ligand for Redox-Switchable Gold-Based Catalysis. A Detailed Study on the Redox-Switching Abilities of the Ligand by Susana Ibáñez (1607290)

“…The analysis of the electron-donating character of the neutral ligand and the ligand resulting from the oxidation was carried out by studying the variation of the ν­(CO) stretching frequencies of Fc-NHC-IrCl­(CO)₂ and its oxidized analogue, revealing that this shift is 2.9 cm^–1, which is consistent with a decrease of the electron-donating character of the ligand produced by the generation of a positively charged metal complex. …”

“Glowing Head” Mice: A Genetic Tool Enabling Reliable Preclinical Image-Based Evaluation of Cancers in Immunocompetent Allografts by Chi-Ping Day (654566)

“…The antigenicity of optical reporters resulted in a decrease in both the growth and metastatic potential of the labeled tumor in wildtype mice as compared to the GH mice. …”

Rational Design of Suprastat: A Novel Selective Histone Deacetylase 6 Inhibitor with the Ability to Potentiate Immunotherapy in Melanoma Models by Satish Noonepalle (7344425)

“…<i>In vivo</i> studies reveal that a combination of Suprastat and anti-PD1 immunotherapy enhances antitumor immune response, mediated by a decrease of protumoral M2 macrophages and increased infiltration of antitumor CD8+ effector and memory T-cells.…”

Alteration of Fractional Anisotropy and Mean Diffusivity in Glaucoma: Novel Results of a Meta-Analysis of Diffusion Tensor Imaging Studies by Ke Li (106849)

“…<div><p>Objectives</p><p>We hypothesized that a meta-analysis of existing studies may help to reveal significant changes on diffusion tensor imaging (DTI) in patients with glaucoma. …”

Data Sheet 1_Expression and prognostic significance of the m6A RNA methylation regulator HNRNPC in HNSCC.docx by Yulin Zhang (510822)

“…Knockdown of HNRNPC in the HNSCC cell lines HSC-3 and CAL-27 resulted in a significant decrease in proliferation, invasion, and malignant transformation abilities. …”

Data_Sheet_1_Lipoproteins Cause Bone Resorption in a Mouse Model of Staphylococcus aureus Septic Arthritis.PDF by Michelle Schultz (12216053)

“…<p>Septic arthritis, most often caused by Staphylococcus aureus, is a rapidly progressive and destructive joint disease with substantial mortality and morbidity. …”

A tension-independent mechanism reduces Aurora B-mediated phosphorylation upon microtubule capture by CENP-E at the kinetochore by Carmen Taveras (6731699)

“…Current models suggest that tension exerted between a pair of sister-kinetochores (inter-kinetochore stretch) produces a spatial separation of Aurora B kinase from kinetochore-associated microtubule binding substrates, such as the Knl1-Mis12-Ndc80 (KMN) network, resulting in a decrease of phosphorylation and, thus, an increase of affinity for microtubules. …”

Presentation1_From a long-term dynamic perspective: how should internal carbon pricing be implemented?.pdf by Liu Yanfei (17709678)

“…Due to short-sighted behavior, both enterprises’ profits and carbon emissions gradually decrease, leading to the internal carbon prices of enterprises under the three strategies will approach a stable value.…”

Data_Sheet_3_Sex, Age, and Bacteria: How the Intestinal Microbiota Is Modulated in a Protandrous Hermaphrodite Fish.PDF by M. Carla Piazzon (5576864)

“…Pathway analysis performed with the inferred metagenome showed significant differences between 1-year-old males and 4-year-old females, with an increase in infection-related pathways, nitrotoluene degradation and sphingolipid metabolism, and a significant decrease in carbohydrate metabolism pathways with age. …”

Environmental dependence of the total CaCO₃ precipitated during a bloom of evolutionarily optimized coccolithophores. by Takahiro Irie (239664)

“…<p>The population-wise carbon fixation (<i>W</i>) is given as the sum of the CaCO₃ left during the bloom (<i>W</i>₁) and the CaCO₃ carried over until the end of the bloom (<i>W</i>₂). (A) Both <i>W</i>₁ (solid line) and <i>W</i>₂ (dashed line) decrease and then increase with increasing net production coefficient (<i>a</i>) with <i>s</i> = 0.001. …”

Lack of RsmA-Mediated Control Results in Constant Hypervirulence, Cell Elongation, and Hyperflagellation in <em>Pectobacterium wasabiae</em> by Viia Kõiv (276156)

“…In this study the physiological role of gene regulation by RsmA is under investigation. Disruption of <em>rsmA</em> gene of the <em>Pectobacterium wasabiae</em> strain, SCC3193 resulted in 3-fold decrease in growth rate and increased virulence. …”

Table_2_Efficacy and Safety of Empagliflozin on Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis.xlsx by Yuyuan Zhang (1275144)

“…Objective<p>Clinical trials have recently shown a connection between nonalcoholic fatty liver disease (NAFLD) and empagliflozin. …”