The Orally Available, Synthetic Ether Lipid Edelfosine Inhibits T Cell Proliferation and Induces a Type I Interferon Response by Pierre Abramowski (542289)

“…Low doses of edelfosine led to a decrease in homeostatic proliferation, and further studies of the mechanism/s of action by genome-wide transcriptional profiling showed that edelfosine reduces the expression of MHC class II molecules, of molecules involved in MHC class II-associated processing and presentation, and finally upregulated a series of type I interferon-associated genes. …”

Image_1_Neurotransmitter content heterogeneity within an interneuron class shapes inhibitory transmission at a central synapse.JPEG by Dimitri Dumontier (14326518)

“…We isolate a slow spillover component of GrCs inhibition that is also affected by the expression of GlyT2, leading to a 56% decrease in relative charge. …”

Identification and Analysis of Genetic Variations in Pri-MiRNAs Expressed Specifically or at a High Level in Sheep Skeletal Muscle by Wei Zhang (405)

“…Three variations were further researched in a larger sample set, including five sheep breeds with different meat production performances. …”

Synthesis, Structure, and Physical Properties for a Series of Monomeric Iron(III) Hydroxo Complexes with Varying Hydrogen-Bond Networks by Jhumpa Mukherjee (2012404)

“…Spectroscopic trends were also found, including an increase in the energy of the O−H vibrations with a decrease in the number of hydrogen bonds. However, the Fe^III/II reduction potentials were constant throughout the series (∼2.0 V vs [Cp₂Fe]^0/+1), which is ascribed to a balancing of the primary and secondary coordination-sphere effects.…”

GTPase activity restores the ability of GEFs to positively regulate a G protein by moving the system away from equilibrium. by Rob J. Stanley (3177219)

“…The shaded region denotes the region which is most likely to be physiologically relevant. <b>A</b> In the absence of GTPase activity, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0151861#pone.0151861.e016" target="_blank">Eq 5</a>, increasing the GEF concentration can only decrease the steady-state concentration of active G protein, instead producing GEF·G protein complexes. …”

Impact of bundle implementation on the incidence of peri/intraventricular hemorrhage among preterm infants: a pre-post interventional study by Cristiane Akemi Koyama Wallau (12800532)

“…OBJECTIVE: To evaluate the efficacy of a bundle of interventions designed to decrease the incidence of intraventricular hemorrhage at hospital discharge among preterm infants. …”

Datasheet1_Causal relationship between immunophenotypes and mitral valve prolapse: a bidirectional Mendelian randomization study.pdf by Yue Wang (65477)

“…Background<p>Emerging evidence indicates a significant link between various immune cell types and the development of heart valve disorders. …”

Rational Design of Suprastat: A Novel Selective Histone Deacetylase 6 Inhibitor with the Ability to Potentiate Immunotherapy in Melanoma Models by Satish Noonepalle (7344425)

“…<i>In vivo</i> studies reveal that a combination of Suprastat and anti-PD1 immunotherapy enhances antitumor immune response, mediated by a decrease of protumoral M2 macrophages and increased infiltration of antitumor CD8+ effector and memory T-cells.…”

Table_1_Efficacy and Safety of Empagliflozin on Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis.docx by Yuyuan Zhang (1275144)

“…Objective<p>Clinical trials have recently shown a connection between nonalcoholic fatty liver disease (NAFLD) and empagliflozin. …”

Data_Sheet_1_Sex, Age, and Bacteria: How the Intestinal Microbiota Is Modulated in a Protandrous Hermaphrodite Fish.PDF by M. Carla Piazzon (5576864)

“…Pathway analysis performed with the inferred metagenome showed significant differences between 1-year-old males and 4-year-old females, with an increase in infection-related pathways, nitrotoluene degradation and sphingolipid metabolism, and a significant decrease in carbohydrate metabolism pathways with age. …”

Aβ-induced dispersal of Homer1b and Shank1 clusters does not depend upon protein degradation. by Francesco Roselli (211670)

“…(C) Neither proteasomal activity nor <i>de novo</i> protein synthesis were found to be necessary for Aβ-induced dispersal of Shank1 clusters. (D) Exposure to Aβ for up to 120 min. did not lead to down-regulation of Shank1 levels in whole cell protein extracts; however, a significant decrease in Shank1 was observed after 180 min of exposure to Aβ (80.7±9.7% of baseline; p<0.05). …”

Data_Sheet_1_Evolutionarily Stable Coevolution Between a Plastic Lytic Virus and Its Microbial Host.pdf by Melinda Choua (10829088)

“…Cell size, for example, is a fundamental trait for microbial hosts that can not only alter the probability of viral adsorption, but also constrain the host physiological processes that the virus relies on to replicate. …”

Rational Design of Suprastat: A Novel Selective Histone Deacetylase 6 Inhibitor with the Ability to Potentiate Immunotherapy in Melanoma Models by Satish Noonepalle (7344425)

“…<i>In vivo</i> studies reveal that a combination of Suprastat and anti-PD1 immunotherapy enhances antitumor immune response, mediated by a decrease of protumoral M2 macrophages and increased infiltration of antitumor CD8+ effector and memory T-cells.…”

Schematic representation of podoplanin pull-down by Fc-CLEC-2 and protein A beads and subsequent slot blot analysis. by Nobuo Watanabe (845921)

“…If a test compound inhibits the interaction between Fc moiety and protein A, slot intensity for Fc-CLEC-2 is expected to decrease.…”

Ferrocenyl-Imidazolylidene Ligand for Redox-Switchable Gold-Based Catalysis. A Detailed Study on the Redox-Switching Abilities of the Ligand by Susana Ibáñez (1607290)

“…The analysis of the electron-donating character of the neutral ligand and the ligand resulting from the oxidation was carried out by studying the variation of the ν­(CO) stretching frequencies of Fc-NHC-IrCl­(CO)₂ and its oxidized analogue, revealing that this shift is 2.9 cm^–1, which is consistent with a decrease of the electron-donating character of the ligand produced by the generation of a positively charged metal complex. …”

Image_1_Receptor/Raft Ratio Is a Determinant for LRP6 Phosphorylation and WNT/β-Catenin Signaling.PDF by Fiete Haack (707641)

“…<p>Microdomains or lipid rafts greatly affect the distribution of proteins and peptides in the membrane and play a vital role in the formation and activation of receptor/protein complexes. …”

Commercial impact of adding real-world evidence to clinical trials at regulatory approval: a Markovian-like transition model by Ravi Jandhyala (8494437)

“…<p>Regulatory use of real-world evidence (RWE) has been recognized as a useful supplement to clinical trial evidence and could benefit patients by reducing time to treatment. …”

Biofilm imaging using wheat germ agglutinin (WGA) shows a loss of VPS following RbmB incubation. by Ranjuna Weerasekera (20371182)

“…The WGA signal remained strong in the Δ<i>rbmB</i> mutant biofilms (top row), while addition of 50 μg/mL RbmB led to a decrease in the WGA signal (middle row). The lower row shows the same experiment with the wild-type strain. …”

Genetic Analysis of Baker's Yeast Msh4-Msh5 Reveals a Threshold Crossover Level for Meiotic Viability by K. T. Nishant (13769)

“…The <em>msh4/5-t</em> mutants also displayed synaptonemal complex assembly defects. A triple mutant containing a <em>msh4/5-t</em> allele and mutations that decreased meiotic double-strand break levels (<em>spo11-HA</em>) and crossover interference (<em>pch2Δ</em>) showed synergistic defects in spore viability. …”

Table_1_Intestinal metabolites and the risk of autistic spectrum disorder: A two-sample Mendelian randomization study.xls by Deyang Liu (12256569)

“…Background<p>Observational studies have reported a strong association between autistic spectrum disorder (ASD) and intestinal metabolites. …”