Supplementary Material for: Autologous Cell Therapy for Aged Human Skin: A Randomized, Placebo-Controlled, Phase-I Study by Grether-Beck S. (7370654)

“…<b><i>Introduction:</i></b> Skin ageing involves senescent fibroblast accumulation, disturbance in extracellular matrix (ECM) homeostasis, and decreased collagen synthesis. <b><i>Objective:</i></b> to assess a cell therapy product for aged skin (RCS-01; verum) consisting of ~25 × 10⁶ cultured, autologous cells derived from anagen hair follicle non-bulbar dermal sheath (NBDS). …”

Image1_Vitamin D Receptor-Dependent Protective Effect of Moderate Hypoxia in a Mouse Colitis Model.pdf by Zheng Wang (25883)

Video 2_Case Report: Concurrent atrial and ventricular septal defect in a young Sphynx cat.mp4 by Jihoon Lee (784361)

“…<p>Concurrent atrial septal defect (ASD) and ventricular septal defect (VSD) are rare in cats. A 7-month-old intact female Sphynx cat was presented for evaluation of respiratory distress and exercise intolerance. …”

DataSheet1_Hepatic and pulmonary macrophage activity in a mucosal challenge model of Ebola virus disease.zip by Timothy G. Wanninger (20296455)

“…Hepatic macrophages also showed differential expression of gene sets related to monocyte/macrophage differentiation, antigen presentation, and T cell activation, which were associated with decreased MHC-II allele expression. Moreover, hepatic macrophages had enriched expression of genes and proteins targetable with known immunomodulatory therapeutics, including S100A9, IDO1, and CTLA-4. …”

DataSheet2_Hepatic and pulmonary macrophage activity in a mucosal challenge model of Ebola virus disease.zip by Timothy G. Wanninger (20296455)

“…Hepatic macrophages also showed differential expression of gene sets related to monocyte/macrophage differentiation, antigen presentation, and T cell activation, which were associated with decreased MHC-II allele expression. Moreover, hepatic macrophages had enriched expression of genes and proteins targetable with known immunomodulatory therapeutics, including S100A9, IDO1, and CTLA-4. …”

Image_1_Causal association of sarcopenia with hepatocellular carcinoma risk in European population: a Mendelian randomization study.pdf by Jiali Cao (5182079)

“…Background<p>The causal association of sarcopenia with the incidence risk of hepatocellular carcinoma (HCC) in the European population, and the potential mediating role of C-reactive protein (CRP), remains unclear. This study employed a bidirectional two-sample, two-step Mendelian randomization (MR) analysis to investigate the causality and identify the mediator.…”

Table_1_Causal relationship between Alzheimer’s disease and prostate cancer: a bidirectional Mendelian randomization analysis.xlsx by Rongkang Li (11865425)

“…</p>Conclusion<p>The results of this study demonstrated an absence of bidirectional causality between AD and PCa among the European population, suggested that a genetically predicted possibility of decreased PCa risk in AD patients, and no significant genetically predicted causal effect of PCa on AD.…”

Communal roosts of the Blue-fronted Amazons (<i>Amazona aestiva</i>) in a large tropical wetland: Are they of different types? by Gláucia Helena Fernandes Seixas (5866511)

“…This is of concern, as it indicates problems in population recruitment, which could have been unnoticed by the management authorities, as the total numbers were not decreasing. Although every monitored roost had birds of each age or reproductive condition strata, the fact that the roosts were different could be important in terms of management, as it will be more effective for the conservation of the Blue-fronted Amazon to protect a carefully chosen set of complementary roosts.…”

Table_2_Use of Haploid Model of Candida albicans to Uncover Mechanism of Action of a Novel Antifungal Agent.XLSX by Thuyen Truong (5351702)

“…Consistently, supplementing the resistant strains, GZY803, and SC5314 with peptone, a form of digested peptides, decreased susceptibility to SM21. …”

Data_Sheet_3_Respiratory muscle ultrasonography evaluation and its clinical application in stroke patients: A review.docx by Xiaoman Liu (109881)

“…Stroke disrupts multiple functions, and the respiratory function is often significantly decreased in stroke patients.</p>Method<p>A search of the MEDLINE, Web of Science, and PubMed databases was conducted. …”

Image 7_PABPN1 as a pan-cancer biomarker: prognostic significance and association with tumor immune microenvironment.png by Hong-Xing Li (316258)

“…Objective<p>This study aimed to investigate the role of poly(A) binding protein nuclear 1 (PABPN1) as a potential pan-cancer biomarker for prognosis and immunotherapy.…”

Genetic dissection of the relationships between grain yield components by genome-wide association mapping in a collection of tetraploid wheats by Giacomo Mangini (427579)

“…<div><p>Increasing grain yield potential in wheat has been a major target of most breeding programs. Genetic advance has been frequently hindered by negative correlations among yield components that have been often observed in segregant populations and germplasm collections. …”

Preventing glaucoma progression using the trabecular micro-bypass implant iStent inject®. A cost-effectiveness analysis by Ricardo Augusto Paletta Guedes (12688873)

“…<div><p>ABSTRACT Objective To assess the economic impact of reducing glaucoma progression by using the trabecular micro-bypass implant, iStent inject®, in the Reference Centers for glaucoma treatment within the Brazilian Public Unified Health System (SUS). Methods In a cost-effectiveness analysis, a Markov model was developed, and the costs were obtained from the SUS perspective (medical direct costs). …”

Table 4_PABPN1 as a pan-cancer biomarker: prognostic significance and association with tumor immune microenvironment.xlsx by Hong-Xing Li (316258)

“…Objective<p>This study aimed to investigate the role of poly(A) binding protein nuclear 1 (PABPN1) as a potential pan-cancer biomarker for prognosis and immunotherapy.…”

DataSheet_1_Early Thymectomy Is Associated With Long-Term Impairment of the Immune System: A Systematic Review.docx by Nara Vasconcelos Cavalcanti (11755088)

“…</p>Results<p>Twenty-three studies were selected and showed that patients who underwent a thymectomy in the first years of life tended to exhibit important alterations in the T cell compartment, such as fewer total T cells, CD4+, CD8+, naïve and CD31+ T cells, lower TRECs, decreased diversity of the TCR repertoire and higher peripheral proliferation (increased Ki-67 expression) than controls. …”

Switchable Dielectric Phase Transition with Drastic Symmetry Breaking in a Sn(IV)-Based Perovskite-Type Halide Semiconductor by Xiu-Ni Hua (1678858)

“…Variable-temperature structure analyses disclose that the drastic symmetry breaking occurs with the structure transferring from <i>Fm</i>3̅<i>m</i> to <i>C</i>2/<i>c</i> by the temperature decreasing. The mechanism of such a transition is associated with the order–disorder transformation of organic ammonium and the displacement of the inorganic framework, which benefits from the discrete anionic architectures that provide enough space. …”

Table_1_Body fat ratio as a novel predictor of complications and survival after rectal cancer surgery.DOCX by Haiyuan Zhao (9284133)

“…</p>Conclusion<p>BFR was associated with BMI, VFA, and VFD. A BFR threshold of 24.3 was correlated with decreased complications and enhanced long-term survival.…”

Image_1_Causal relationship between Alzheimer’s disease and prostate cancer: a bidirectional Mendelian randomization analysis.pdf by Rongkang Li (11865425)

“…</p>Conclusion<p>The results of this study demonstrated an absence of bidirectional causality between AD and PCa among the European population, suggested that a genetically predicted possibility of decreased PCa risk in AD patients, and no significant genetically predicted causal effect of PCa on AD.…”

Prognostic Significance of Nutrition-Associated Markers in Heart Failure with Preserved Ejection Fraction: A Systematic Review and Meta-Analysis by Ying Meng (327793)

“…The analyses showed that a decreased SA or GNRI was significantly related to high all-cause mortality (HR: 1.98; 95% CI: 1.282–3.057; p = 0.002; and HR: 1.812;95% CI: 1.064–3.086; p = 0.029, respectively). …”

Table_2_A Comparative Study for License Application Regulations on Proprietary Chinese Medicines in Hong Kong and Canada.DOCX by Linda L. D. Zhong (5006042)

“…<p>Ethnopharmacological Relevance: Chinese Medicine plays a symbolic role among traditional medicines. As Chinese Medicine products are widely used around the globe, regulations for Chinese Medicine products are often used as models for the efficient regulation of natural products that are safe, and high-quality.…”