Degradation of a VX Analogue: First Organometallic Reagent To Promote Phosphonothioate Hydrolysis Through Selective P−S Bond Scission by Louis Y. Kuo (1915309)

“…We report the first case of a metal complex that degrades a neurotoxin mimic under extremely mild conditions (pH 6.8, room temperature). …”

Table_1_A synonymous mutation in PI4KA impacts the transcription and translation process of gene expression.docx by Kaihui Zhang (2162758)

“…<p>Phosphatidylinositol-4-kinase alpha (PI4KIIIα), encoded by the PI4KA gene, can synthesize phosphatidylinositol-4-phosphate (PI-4-P), which serves as a specific membrane marker and is instrumental in signal transduction. …”

Data_Sheet_1_Causal Association Between Tea Consumption and Bone Health: A Mendelian Randomization Study.docx by Song Chen (69646)

“…To determine the causal relationship between genetically predicted tea intake and OA, RA, and OP, we performed a two-sample Mendelian randomization (MR) study based on large samples.…”

Table_8_Effects of Flavonoid Supplementation on Nanomaterial-Induced Toxicity: A Meta-Analysis of Preclinical Animal Studies.DOCX by Dongli Xie (400786)

“…STATA 15.0 software was used for meta-analyses.</p>Results<p>A total of 26 studies were identified. The results showed that flavonoid supplementation could significantly increase the levels of antioxidative enzymes (superoxide dismutase, catalase, glutathione, glutathione peroxidase, and glutathione-S-transferase), reduce the production of oxidative agents (malonaldehyde) and pro-inflammatory mediators (tumor necrosis factor-α, interleukin-6, IL-1β, C-reactive protein, immunoglobulin G, nitric oxide, vascular endothelial growth factor, and myeloperoxidase), and alleviate cell apoptosis (manifested by decreases in the mRNA expression levels of pro-apoptotic factors, such as caspase-3, Fas cell surface death receptor, and Bax, and increases in the mRNA expression levels of Bcl2), DNA damage (reductions in tail length and tail DNA%), and nanomaterial-induced injuries of the liver (reduced alanine aminotransferase and aspartate aminotransferase activities), kidney (reduced urea, blood urea nitrogen, creatinine, and uric acid concentration), testis (increased testosterone, sperm motility, 17β-hydroxysteroid dehydrogenase type, and reduced sperm abnormalities), and brain (enhanced acetylcholinesterase activities). …”

Video1_Journey through a virtual tunnel: Simulated motion and its effects on the experience of time.MP4 by Maximilian Landeck (11151309)

“…Previous work has shown that the perception of motion can affect the perception of time. We developed a virtual environment that simulates motion in a tunnel and measured its effects on the estimation of the duration of time, the speed at which perceived time passes, and the illusion of self-motion, also known as vection. …”

Image_1_Lutzomyia longipalpis TGF-β Has a Role in Leishmania infantum chagasi Survival in the Vector.TIF by Tatiana Di-Blasi (4680811)

“…The blockage of the LlTGF-β pathway increased significantly antimicrobial peptides expression and nitric oxide levels in the insect gut, as expected. Both methods led to a decreased L. i. chagasi infection. Our results show that inactivation of the L. longipalpis TGF-β signal transduction pathway reduce L. i. chagasi survival, therefore suggesting that under natural conditions the parasite benefits from the insect LlTGF-β pathway, as already seen in Plamodium infection of mosquitoes.…”

Table_9_Effects of Flavonoid Supplementation on Nanomaterial-Induced Toxicity: A Meta-Analysis of Preclinical Animal Studies.DOCX by Dongli Xie (400786)

“…STATA 15.0 software was used for meta-analyses.</p>Results<p>A total of 26 studies were identified. The results showed that flavonoid supplementation could significantly increase the levels of antioxidative enzymes (superoxide dismutase, catalase, glutathione, glutathione peroxidase, and glutathione-S-transferase), reduce the production of oxidative agents (malonaldehyde) and pro-inflammatory mediators (tumor necrosis factor-α, interleukin-6, IL-1β, C-reactive protein, immunoglobulin G, nitric oxide, vascular endothelial growth factor, and myeloperoxidase), and alleviate cell apoptosis (manifested by decreases in the mRNA expression levels of pro-apoptotic factors, such as caspase-3, Fas cell surface death receptor, and Bax, and increases in the mRNA expression levels of Bcl2), DNA damage (reductions in tail length and tail DNA%), and nanomaterial-induced injuries of the liver (reduced alanine aminotransferase and aspartate aminotransferase activities), kidney (reduced urea, blood urea nitrogen, creatinine, and uric acid concentration), testis (increased testosterone, sperm motility, 17β-hydroxysteroid dehydrogenase type, and reduced sperm abnormalities), and brain (enhanced acetylcholinesterase activities). …”

Image_1_Microbiological profile of diabetic foot infections in China and worldwide: a 20-year systematic review.pdf by Yu-dun Qu (17869511)

“…We aimed to determine the incidence and antibiotic susceptibility of DFI pathogens worldwide, focusing on Asia and China.</p>Methods<p>Through a comprehensive literature search, we identified published studies on organisms isolated from DFI wounds from January 2000 to December 2020.…”

Table 2_Association of cardiorespiratory fitness with phenotypic age in younger population: a study based on the NHANES database.docx by Yi Shen (152956)

“…</p>Results<p>In the multivariable logistical regression analysis, maintenance of CRF was significantly and inversely associated with PAA, demonstrating a decreased risk of 42% in the high CRF group [OR (95% CI): 0.58 (0.36, 0.96), p = 0.033]. …”

The observed rostral-lateral phenotype is retained in E14.5 <i>Lmx1a-dr/dr</i>. by Elisa J. Hoekstra (290576)

“…(A–F′′) <i>Lmx1a</i> transcript levels are lowered in <i>Lmx1a-dr/dr</i> (large arrowheads), while between the heterozygous mutant and wild-type control no differences are observed. …”

Data_Sheet_1_A Comprehensive Analysis of Population Differences in LRRK2 Variant Distribution in Parkinson's Disease.pdf by Li Shu (5767922)

“…</p><p>Results: In the absence of obvious heterogeneities and publication biases among the included studies, we concluded that A419V, R1441C/G/H, R1628P, G2019S, and G2385R were associated with increased PD risk (p: 0.001, 0.0004, < 0.00001, < 0.00001, and < 0.00001, respectively), while R1398H was associated with decreased risk (p: < 0.00001). …”

Role of the Zinc Finger Transcription Factor SltA in Morphogenesis and Sterigmatocystin Biosynthesis in the Fungus <i>Aspergillus nidulans</i> by Sourabha Shantappa (428931)

“…Addition of potassium to <i>sltA</i> deletion mutants resulted in decreased levels of sterigmatocystin production. …”

Table 1_Urinary and oral microbiota in Polish women: a pilot case-control study of breast cancer.docx by Anna Marciniak (12354534)

“…Introduction<p>The human microbiota can be a critical component in the development and progression of various diseases, including cancer. …”

Table_2_Biogenic Silver Nanoparticles as a Post-surgical Treatment for Corynebacterium pseudotuberculosis Infection in Small Ruminants.docx by Laerte Marlon Santos (6628370)

“…It can be concluded that post-surgical treatment of CL using the AgNP-based ointment may be a promising tool in the control of CL, through faster healing, decreased wound contamination, and no apparent toxic effects.…”

Image_1_A population of dermal Langerin+ dendritic cells promote the inflammation in mouse model of atopic dermatitis.tif by Chunying Xiao (8612091)

Experimental Reactivation of Pulmonary <i>Mycobacterium avium</i> Complex Infection in a Modified Cornell-Like Murine Model by Seung Bin Cha (800579)

“…To this end, we employed a modified Cornell-like murine model of tuberculosis and investigated six strains consisting of two type strains and four clinical isolates of <i>M</i>. …”

DataSheet1_Lithium-induced apoptotic cell death is not accompanied by a noticeable inflammatory response in the kidney.docx by Irina Baranovskaya (8166219)

“…The TUNEL-positive signal and levels of pro-apoptotic proteins, Bax, cleaved caspase-3, and caspase-8, were elevated in the kidneys of Li⁺-treated mice. We observed a significantly higher abundance of CD93, CCL21, and fractalkine, accumulation of F4.80⁺ macrophages with reduced M1/M2 polarization ratio and decreased CD4⁺ levels in the renal tissue of Li⁺-treated mice when compared to controls. …”

Image_3_Use of Clinical Isolates to Establish Criteria for a Mouse Model of Latent Cryptococcus neoformans Infection.jpeg by Minna Ding (12031985)

“…In this study, we defined criteria required for latency in C. neoformans infection models and used these criteria to develop a murine model of persistent C. neoformans infection using clinical isolates. …”

In Vitro Effects of a Small-Molecule Antagonist of the Tcf/ß-Catenin Complex on Endometrial and Endometriotic Cells of Patients with Endometriosis by Sachiko Matsuzaki (405488)

“…</p><p>Objectives</p><p>The aim of the present study was to evaluate the effects of a small-molecule antagonist of the Tcf/ß-catenin complex (PKF 115–584) on cell proliferation, migration, and invasion of endometrial and endometriotic epithelial and stromal cells.…”

Audio_1_Influence of Auditory Cues on the Neuronal Response to Naturalistic Visual Stimuli in a Virtual Reality Setting.WAV by George Al Boustani (12717983)

“…To investigate the effect of additional auditory cues on the processing of visual information, we used virtual reality to mimic safety-related events in an industrial environment while we concomitantly recorded electroencephalography (EEG) signals. We simulated a box traveling on a conveyor belt system where two types of stimuli – an exploding and a burning box – interrupt regular operation. …”