A genetically engineered microRNA-34a prodrug demonstrates anti-tumor activity in a canine model of osteosarcoma by Fernando Alegre (6166193)

“…Additionally, our subcutaneous OSA xenograft model demonstrated <i>in vivo</i> tumor growth delay, increased necrosis and apoptosis by tRNA/miR-34a, and decreased cellular proliferation ability. …”

<i>DAPK1</i> Promoter Methylation and Cervical Cancer Risk: A Systematic Review and a Meta-Analysis by Antonella Agodi (638417)

“…The aim of the present study was to carry out a systematic review and a meta-analysis in order to evaluate <i>DAPK1</i> promoter methylation as an epigenetic marker for CC risk.…”

Simplified overview of molecular signalling after sprint exercise. by Hakan Claes Rundqvist (7541837)

“…<p>A selection of stimuli (green–increased and blue—decreased), signalling pathways (red–upregulated and blue–downregulated and downstream biofunctions (yellow) are presented. …”

HHV-6A infection increases glucose metabolism and glycolysis in HSB-2 cells. by Zhisheng Wu (1540864)

“…**p < 0.01, compared with mock infection groups. <b>(C)</b> HHV-6A infection decreased glucose levels in the culture medium of in HSB-2 cells. …”

Information details: cyclin A2 and PHH3 expression. by James W. Jacobberger (184625)

“…A: brackets show are of cyclin A2 decrease in early mitosis; small arrow points to “new born” cells; large arrow points to large cluster in early mitosis, largely composes of prophase cells. …”

Pre-incubation of SB105-A10 either with HIV-1_IIIb or HIV-1_ada strains inhibits the viral infectivity in dilution assay. by Isabella Bon (467395)

“…<p>HIV-1 strains were incubated for 1 hour at 37°C with SB105-A10 (20 µg/ml; 4.2 µM). Following this incubation the samples were diluted 50-fold to reduce dendrimer concentrations to a level below that at which SB105-A10 significantly inhibits HIV replication and challenged with activated PBMCs. …”

T Cell Leukemia/Lymphoma 1A is essential for mouse epidermal keratinocytes proliferation promoted by insulin-like growth factor 1 by Antonella Bresin (5819432)

“…Finally, we found TCL1 to act, at least in part, via increasing phospho-ERK1/2 and decreasing phospho-P38 MAPK. Hence, our data demonstrate that regulated levels of <i>Tcl1a</i> are necessary for the correct proliferation and differentiation of the interfollicular KCs.…”

<i>LDLR</i> and <i>PCSK9</i> Are Associated with the Presence of Antiphospholipid Antibodies and the Development of Thrombosis in aPLA Carriers by Eguzkine Ochoa (429972)

“…Expression level study showed significantly decreased expression level of <i>LDLR</i> gene in aPLA carriers (<i>P</i>-value <0.0001; 95%CI 0.16–2.10; SE 0.38–1.27) in comparison to the control group.…”

Correlation between near-source wastewater SARS-CoV-2 detections and national surveillance, using individual daily data points (top row) and a five-day moving average (bottom row). by Jay C. Bullen (10232606)

DataSheet1_Interactive Effects of Glucocorticoids and Cytochrome P450 Polymorphisms on the Plasma Trough Concentrations of Voriconazole.docx by Su-jie Jia (10869666)

“…The mutation of CYP3A5 has no significant effect. Furthermore, CYP2C19*17 mutants could strengthen the effects of glucocorticoids and decrease VRC C_min/dose to a larger extent.…”

Effects of B31-A3, B31-A spent medium and BSK-II control medium on Lp. by Xueping Zhou (131154)

“…An increase in Lp was only seen upon perfusion with B31-A3 spent medium. D) Summarized data of Lp changes induced by B31-A and B31-A3 spent medium; * indicates a significant increase (P<0.05) from negative control; † indicates a significant decrease (P<0.05) from B31-A3 spent medium.…”

Data Sheet 1_Impact of multiple environmental factors on influenza–like illness in Fujian Province, China, 2015–2023: a multicity study.zip by Xiaoyan Yao (8723622)

“…The NO₂–ILI association was non–linear, resembling an inverted “U” shape, with a risk peak at 40.5 μg/m³. …”

A Γ-type combined structure. by Laite Sun (16726500)

“…The results demonstrate that, with the increase in the input time difference of seismic wave, the bending moment of the control section increases gradually, while the shear force and axial force decrease first and then increase, and traveling wave effect response within a certain range of time difference is weaker than the uniform excitation response. …”

A Practical, Fast, and High-Yielding Aziridination Procedure Using Simple Cu(II) Complexes Containing N-Donor Pyridine-Based Ligands by Fabian Mohr (1457233)

“…High yields of aziridines exceeding 90% can be obtained with a 1:1 olefin/PhINTs ratio and 1−5 mol % catalyst loading for such reactive olefins as styrene, tri- and tetramethylethylene. …”

A Practical, Fast, and High-Yielding Aziridination Procedure Using Simple Cu(II) Complexes Containing N-Donor Pyridine-Based Ligands by Fabian Mohr (1457233)

“…High yields of aziridines exceeding 90% can be obtained with a 1:1 olefin/PhINTs ratio and 1−5 mol % catalyst loading for such reactive olefins as styrene, tri- and tetramethylethylene. …”

Effect of BPA on CYP450s expression, and nicotine modulation, in fetal rat brain by Mohammad H., Merii

“…In addition, nicotine individually decreased expression levels of all examined protein targets, significantly for CYP1B1 (p < 0.001), CYP19A1 (p = 0.010), AhRR (p = 0.042), and ARNT (p < 0.001), compared to control. …”
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Image 1_A rapid and naked-eye methicillin resistant Staphylococcus aureus screening method based on CRISPR/Cas12a and hybridization chain reaction.tif by Yayun Jiang (11556973)

“…In the presence of the DNA targets, the trans-cleavage activity of CRISPR/Cas12a is activated to cleave the trigger strand, failing HCR and leading to a decrease in the fluorescence signal. …”

Supplementary file 1_A rapid and naked-eye methicillin resistant Staphylococcus aureus screening method based on CRISPR/Cas12a and hybridization chain reaction.docx by Yayun Jiang (11556973)

“…In the presence of the DNA targets, the trans-cleavage activity of CRISPR/Cas12a is activated to cleave the trigger strand, failing HCR and leading to a decrease in the fluorescence signal. …”

Influence of Water Ligands on Structural Diversity: From a One-Dimensional Linear Coordination Polymer to Three-Dimensional Ferrimagnetic Diamondoid Metal−Organic Frameworks by Sudarshana Mukherjee (2399392)

LEMming: A Linear Error Model to Normalize Parallel Quantitative Real-Time PCR (qPCR) Data as an Alternative to Reference Gene Based Methods by Ronny Feuer (680689)

“…</p><p>Results</p><p>We developed a RG independent data normalization approach based on a tailored <u>l</u>inear <u>e</u>rror <u>m</u>odel for parallel qPCR data, called LEMming. …”