Impact of the Herbal Medicine <em>Sophora flavescens</em> on the Oral Pharmacokinetics of Indinavir in Rats: The Involvement of CYP3A and P-Glycoprotein by Jia-Ming Yang (182794)

“…Concomitant oral administration of <em>Sophora</em> extract (0.158 g/kg or 0.63 g/kg, p.o.) and indinavir (40 mg/kg, p.o.) in rats twice a day for 7 days resulted in a dose-dependent decrease of plasma indinavir concentrations, with 55%–83% decrease in AUC_0-∞ and 38%–78% reduction in C_max. …”

DataSheet_1_Apolipoprotein A-I levels in the survival of patients with colorectal cancer: a retrospective study.docx by Hailun Xie (10278446)

“…Each one-standard-deviation increase in ApoA-I level was related to a 12.0% decrease in PFS risk (hazard ratio [HR] 0.880; 95% confidence interval [CI], 0.801–0.968; P = 0.009) and an 11.2% decrease in OS risk (HR 0.888; 95%CI, 0.806–0.978; P = 0.015). …”

Wolves are least likely to travel on the night of a snowfall event, compared to dates immediately before or after an event. by Amanda Droghini (5916767)

Decreased neutrophil levels in HIF^C mice correlates to decreased production of CXCL1 and not migration defects. by Kelly M. Shepardson (404375)

The identity of residue 45 determines the dimer-monomer equilibrium of TvTIM1. by Samuel Lara-Gonzalez (831599)

“…The spectra of I45L and I45V superimpose with the wild-type spectra, whereas monomeric constructs present a decrease on ellipticity. <b>(C)</b> Partial proteolysis of TvTIM1 mutants. …”

IDN5706 inhibits proteolytic processing of APP to CTFs, and production of Aβ species. by Viviana A. Cavieres (500139)

Herceptin down-regulates HER2 receptors and decreases HER3 phosphorylation, but it does not decrease HER2 phosphorylation. by Merel Gijsen (234741)

In presence of HGT only, and no diversity-maintenance mechanism, the fixation of a beneficial gene in the metacommunity can lead to a moderate loss of diversity. by Simone Pompei (134652)

Unbiased Passive Sampling of All Polychlorinated Biphenyls Congeners from Air by Yuening Li (12548065)

“…Here, we present the result of a field calibration experiment that demonstrates that even the most volatile PCBs maintain linear uptake in a passive air sampler using XAD-resin as the sorbent (XAD-PAS). …”

Herceptin down-regulates HER2 receptors and decreases HER3 phosphorylation, but it does not decrease HER2 phosphorylation. by Merel Gijsen (234741)

The mass-specific metabolic rate decreases within and between instars (although the within instar decrease is not significant in the third instar). by Viviane Callier (306959)

“…<p>At the beginning of each instar, the supply structures are not constraining, so this decrease is most likely due to a decrease in intrinsic oxygen demand. …”

Added-variable plot of the partial correlation between intelligence (measured with IST-2000-R) and the alpha-to-gamma difference in relative visual-area power (Δ<i>R</i><sub><i>V</... by Anna Horwitz (771335)

Definition of the cell population as MSC. by Fabian Westhauser (5314436)

Flow chart from invitation to analyses. *For administrative reasons HbA1c was not available for a small subset of the population. by Martin Gillies Banke Rasmussen (10227291)

In vitro evaluation of Neosetophomone B inducing apoptosis in cutaneous T cell lymphoma by targeting the FOXM1 signaling pathway by Kuttikrishnan, Shilpa

“…FOXM1 and BUB1B expression exhibited a dose-dependent reduction in NSP-B-treated CTCL cells.FOXM1 silencing decreased cell viability and increased apoptosis via BUB1B downregulation. …”
Get full text
Get full text

Rapamycin treatment prevents decrease of VGLUT2 presynaptic terminals/axons in <i>Npc1</i>^{<i>nmf164</i>} cerebellar ML. by Caroline E. Murray (22190338)

Effect of HCA and HO-1 siRNA in A549 cells subjected to hypoxia-reoxygenation (H/R). by Shu-Yu Wu (129447)

“…(B) HO-1 siRNA blocked the decrease of CXCL8 production by HCA in H/R-exposed A549 cells. …”

ANXA1 decreased p-ERK1/2 accumulation in the nucleus and decreased cyclin D1 expression in PASMCs. by Jing He (58446)

Schematic representation of the effects of stepwise bromination of the benzene ring of benzotriazole (Bt), including interdependence of the molecular volume (A) and pK_a (B) of the products with their IC₅₀ for inhibition of protein kinase CK2α: (a) Green arrows follow sequential bromination of the central vicinal C(5)/C(6) atoms, leading to a moderate decrease of pK_a and a large decrease in IC₅₀; (b) Red arrows illustrate the lesser effects of bromination of the peripheral C(4)/C(7) atoms, resulting in a significant decrease of pK_a, with virtually no gain in inhibitory activity; (c) Black lines link products with the same number of bromine atoms, but substantially differing in pK_a and IC₅₀, culminating in the di- and tri-brominated derivatives with inhibitory activities comparable to that of TBBt. by Romualda Wąsik (119538)

Effect of Bariatric Surgery on Serum Amyloid A Protein: a Systematic Review and Meta-analysis by Jamialahamdi, Tannaz

“…Background: Obesity is a chronic inflammatory condition and this meta-analysis evaluated the impact of bariatric surgery on SAA. …”
Get full text
Get full text
Get full text