Modulation of insulin degrading enzyme activity and liver cell proliferation by Olga Pivovarova (735300)

“…<p>Diabetes mellitus type 2 (T2DM), insulin therapy, and hyperinsulinemia are independent risk factors of liver cancer. Recently, the use of a novel inhibitor of insulin degrading enzyme (IDE) was proposed as a new therapeutic strategy in T2DM. …”

Interaction of FKBP8 with ER specific protein and FKBP8 expression in mitochondria fraction during mitophagy. by Michael O. Isei (20500908)

“…<p>Dual staining for FKBP8 (red) and BiP/GrP78 (green) was performed to analyze their colocalization in unstressed cells <b>(A)</b> and cells induced for mitophagy with PQ for 6 h <b>(B)</b>. …”

Table5_Integrative RNA-Seq and ATAC-Seq Analysis Reveals the Migration-Associated Genes Involved in Antitumor Effects of Herbal Medicine Feiyanning on Lung Cancer Cells.DOCX by Chenyang Wang (170127)

“…Traditional Chinese medicine formula Feiyanning has been clinically administered in China for more than a decade and raised attention due to its anticancer effect in lung cancer. …”

Image 2_Acute stress triggers sex-dependent rapid alterations in the human small intestine microbiota composition.jpeg by Bruno K. Rodiño-Janeiro (20565584)

“…</p>Results<p>Cold pain stress was associated with a significant decrease in alpha diversity (P = 0.015), which was more pronounced in females, along with significant sex differences in the abundance of specific taxa and the overall microbiota composition. …”

Data_Sheet_5_Resolvin E1-ChemR23 Axis Regulates the Hepatic Metabolic and Inflammatory Transcriptional Landscape in Obesity at the Whole Genome and Exon Level.XLSX by Abrar E. Al-Shaer (6580940)

“…Notably, obese WT mice relative to lean controls showed a robust decrease in pathways related to the biosynthesis of unsaturated fatty acids. …”

Individualized pattern recognition for detecting mind wandering from EEG during live lectures by Kiret Dhindsa (7378439)

“…We performed traditional group-level analysis and found neural correlates of mind wandering during live lectures that are similar to those found in some laboratory studies, including a decrease in occipitoparietal alpha power and frontal, temporal, and occipital beta power. …”

Exposure Assessment for Estimation of the Global Burden of Disease Attributable to Outdoor Air Pollution by Michael Brauer (675317)

“…The highest seasonal ozone levels were found in North and Latin America, Europe, South and East Asia, and parts of Africa. Between 1990 and 2005 a 6% increase in global population-weighted PM_2.5 and a 1% decrease in global population-weighted ozone concentrations was apparent, highlighted by increased concentrations in East, South, and Southeast Asia and decreases in North America and Europe. …”

Table_1_Dimethyl fumarate alleviates allergic asthma by strengthening the Nrf2 signaling pathway in regulatory T cells.xlsx by Yanhong Cen (18420282)

“…Histopathological analysis showed that DMF treatment in an OVA-induced animal model eased the inflammation in the nasal and bronchial tissues, with a particular decrease in the infiltration of immune cells. …”

Image_1_miR-344-5p Modulates Cholesterol-Induced β-Cell Apoptosis and Dysfunction Through Regulating Caveolin-1 Expression.tif by Xulong Sun (11195769)

“…<p>Diabetes is a metabolic disorder induced by the modulation of insulin on glucose metabolism, and the dysfunction and decreased number of islets β-cells are the main causes of T2DM (type 2 diabetes mellitus). …”

Image 6_Therapeutic plasma exchange accelerates immune cell recovery in severe COVID-19.jpeg by Aurelie Guironnet-Paquet (15407171)

“…</p>Methods<p>In this study, we set up a prospective, randomised clinical trial (ClinicalTrials.gov ID: NCT04751643) and performed therapeutic plasma exchange (TPE) in severe COVID-19 patients in order to decrease excess cytokines and auto-antibodies and to assess whether adding TPE to the standard treatment (ST, including corticosteroids plus high-flow rate oxygen) could help restore immune parameters and limit the progression of acute respiratory distress syndrome (ARDS).…”

Image1_Antisense lncRNA CHROMR is linked to glioma patient survival.pdf by Dovydas Širvinskas (14722087)

“…<p>Background: Natural non-coding antisense transcripts (ncNATs) are long non-coding RNAs (lncRNA) transcribed from the opposite strand of a separate protein coding or non-coding gene. As such, ncNATs can increase overlapping mRNA (and the coded protein) levels by stabilizing mRNA, absorbing inhibitory miRNAs and protecting the mRNA from degradation, or conversely decrease mRNA (or protein) levels by directing the mRNA towards degradation or inhibiting protein translation. …”

Randomized double-blinded pilot clinical study of the antidiabetic activity of <i>Balanites aegyptiaca</i> and UPLC-ESI-MS/MS identification of its metabolites by Hend Rashad (4260301)

“…</p> <p><b>Results:</b> Thirteen compounds were identified in BE using UPLC-ESI-MS/MS analysis among which five steroidal saponins, seven phenolic compounds and a sterol glucoside. At the end of the 8-week treatment, the treated group showed 26.88% decrease in 2 h postprandial plasma glucose relative to 2.6% increase in the placebo group, while fasting plasma glucose was reduced to 10.3%. …”

Image_2_Antifungal, Plant Growth-Promoting, and Genomic Properties of an Endophytic Actinobacterium Streptomyces sp. NEAU-S7GS2.TIF by Dongli Liu (2580382)

“…These results suggested that strain NEAU-S7GS2 may be a potential biocontrol agent and biofertilizer used in agriculture.…”

Data_Sheet_1_Immunohistological and Ultrastructural Study of the Inflammatory Response to Perforated Polyimide Cortical Implants: Mechanisms Underlying Deterioration of Electrophys... by Shun-Ho Huang (9322052)

“…Recognizing that the seal resistance formed by adhering-microglia to the implant constitutes a downstream element undermining extracellular FP recordings, suggests that approaches to mitigate the formation of the insulating glial could lead to improved recording quality and yield.…”

Table_7_Comparative Physiological and Transcriptome Profiles Uncover Salt Tolerance Mechanisms in Alfalfa.XLSX by Jiali Li (436886)

“…It was interesting to find that salinity caused a decrease in total unsaturated fatty acid in Adrenalin other than Magnum Salt, C18:2 was increased significantly after salinity in Magnum Salt, while it was unaltered in Adrenalin. …”

Image_1_Conventional-Vincristine Sulfate vs. Modified Protocol of Vincristine Sulfate and L-Asparaginase in Canine Transmissible Venereal Tumor.TIF by Chanokchon Setthawongsin (6568634)

“…<p>Background: Vincristine (VCR) is a mono-chemotherapy for canine transmissible venereal tumor (CTVT). …”

DataSheet1_Combined Administration of Vitamin D3 and Geniposide Is Less Effective than Single Use of Vitamin D3 or Geniposide in the Treatment of Ulcerative Colitis.PDF by Yingyu Lu (11492644)

“…This study was designed to determine the efficacy and mechanism of the single use and combination of geniposide and vitamin D₃ on a mouse model of acute colitis. Data showed that a single administration of geniposide (2 mg/kg) or vitamin D₃ (4 IU/day) could significantly improve the symptoms of UC and relieve colon damage. …”

Analysis of DRD1 and DRD2 signalling upon dopamine treatment in SH-SY5Y-DRD1 or -DRD2 stable lines untransduced or transduced by WT or G2019S LRRK2. by Mauro Rassu (4068670)

“…<p><b>(A)</b> Cells stably expressing FLAG-tagged DRD1 were transduced by the different LRRK2 isoforms. 48h after transduction the cell were treated for different time points (15', 30', 60') by dopamine. …”

Image_2_Protective Effect of Stachydrine Against Cerebral Ischemia-Reperfusion Injury by Reducing Inflammation and Apoptosis Through P65 and JAK2/STAT3 Signaling Pathway.tif by Li Li (14993)

“…<p>Stachydrine, a constituent of Leonurus japonicus Houtt which also called Japanese motherwort has been shown to improve vascular microcirculation and ameliorate endothelial dysfunction. …”

Image_5_OsDDM1b Controls Grain Size by Influencing Cell Cycling and Regulating Homeostasis and Signaling of Brassinosteroid in Rice.TIF by Mingliang Guo (4877395)

“…Consistent with the grain size, the outer parenchyma cell layers of lemma in osddm1b developed more cells with decreased size. OsDDM1b encoded a nucleus, membrane-localized protein and was distributed predominately in young spikelets and seeds, asserting its role in grain size. …”