DataSheet_1_Severe COVID-19 Is Associated With an Altered Upper Respiratory Tract Microbiome.docx by Meghan H. Shilts (5900660)

“…</p>Objective<p>Our primary objective was to identify URT microbiome signature/s that consistently changed over a spectrum of COVID-19 severity.</p>Methods<p>Using data from 103 adult participants from two cities in the United States, we compared the bacterial load and the URT microbiome between five groups: 20 asymptomatic SARS-CoV-2-negative participants, 27 participants with mild COVID-19, 28 participants with moderate COVID-19, 15 hospitalized patients with severe COVID-19, and 13 hospitalized patients in the ICU with very severe COVID-19.…”

Data_Sheet_1_Qin-Qiao-Xiao-Du formula alleviate influenza virus infectious pneumonia through regulation gut microbiota and metabolomics.pdf by Bo Lian (2009434)

“…<p>Qin-Qiao-Xiao-Du (QQXD), a traditional Chinese medicine (TCM) formula, has been used in the clinical treatment of influenza virus pneumonia. …”

Image 5_Therapeutic plasma exchange accelerates immune cell recovery in severe COVID-19.jpeg by Aurelie Guironnet-Paquet (15407171)

“…</p>Methods<p>In this study, we set up a prospective, randomised clinical trial (ClinicalTrials.gov ID: NCT04751643) and performed therapeutic plasma exchange (TPE) in severe COVID-19 patients in order to decrease excess cytokines and auto-antibodies and to assess whether adding TPE to the standard treatment (ST, including corticosteroids plus high-flow rate oxygen) could help restore immune parameters and limit the progression of acute respiratory distress syndrome (ARDS).…”

Image_1_Early Everolimus Initiation Fails to Counteract the Cytotoxic Response Mediated by CD8+ T and NK Cells in Heart Transplant Patients.TIF by Beatriz Díaz-Molina (5791361)

“…Our results imply that only early EVL conversion induces key changes in the post-transplant immune response, preserving an efficient anti-viral response, but simultaneously showing a limited ability to counteract the cytotoxic response to the allograft.…”

Data_Sheet_1_Projecting shifts in the distributions of Chinese endemic vertebrate species under climate and land-use change.pdf by Yiming Deng (2814844)

“…<p>Human-induced climate and land-use change impact species’ habitats and survival ability. A growing body of research uses species distribution models (SDMs) to predict potential changes in species ranges under global change. …”

Table_1_TIPE2 Suppresses Malignancy of Pancreatic Cancer Through Inhibiting TGFβ1 Mediated Signaling Pathway.docx by Fang Feng (2315416)

“…Moreover, the tumor-infiltrating lymphocytes from tumor-bearing mice were analyzed by flow cytometry, and showed that TIPE2 could promote T cell activation to exert an anti-tumor effect possibly through activation of DCs in a TGFβ1 dependent manner. In general, we described the multiple regulatory mechanisms of TIPE2 in pancreatic tumorigenesis and tumor microenvironment, which suggested TIPE2 may act as a potential therapeutic target in pancreatic cancer.…”

Image_5_Alcohol Impairs Immunometabolism and Promotes Naïve T Cell Differentiation to Pro-Inflammatory Th1 CD4+ T Cells.tif by Patrick M. McTernan (341264)

“…These results suggest that ethanol impairs CD4⁺ T cell immunometabolism and disrupts mitochondrial repair processes as it promotes CD4⁺ T cell differentiation to a pro-inflammatory phenotype.</p>…”

Image1_Iodide uptake by forest soils is principally related to the activity of extracellular oxidases.TIFF by Russell M. Grandbois (14703175)

“…Autoclaved soils, and soils amended with an enzyme inhibitor (sodium azide) or an antibacterial agent (bronopol), bound significantly less ¹²⁵I tracer (93%, 81%, 61% decrease, respectively) than the untreated control soils, confirming a microbial role in soil iodide uptake. …”

Image1_Age and Gender Specific Lung Cancer Incidence and Mortality in Hungary: Trends from 2011 Through 2016.JPEG by Lilla Tamási (177760)

“…The male-to-female incidence rate ratio reached 2.46–3.01 (p < 0.0001) among the 70–79 age group. We found 2–11% decrease in male incidence rate at most age groups, while a significant 1–3% increase was observed in older females (>60) annually during the study period.…”

Table1_Using Lidar and Historical Similar Meteorological Fields to Evaluate the Impact of Anthropogenic Control on Dust Weather During COVID-19.DOCX by Bin Chen (63682)

“…During the transportation, dust can interact with local air-borne dust and pollutants, and has a profound impact on the environment. A novel coronavirus (COVID-19) has been affecting human activities worldwide since early 2020. …”

STIM1 expression closely related to HNSCC cell apoptosis and participated in TG-induced ER stress. by Ping Li (31981)

“…<p>(A) Transfected with STIM1-siRNA in TSCCA and Hep2 could significantly increase cell apoptosis compared with control groups by FACS detection. …”

<i>Mtb</i>-mediated phagosome disruption in different phagocyte types, relationship with infection dose and cell death. by Roxane Simeone (185592)

“…<p>(A) Comparative infectivity of WT and ΔESX-1 <i>Mtb</i>. …”

Marangoni Droplets of Dextran in PEG Solution and Its Motile Change Due to Coil–Globule Transition of Coexisting DNA by Tomohiro Furuki (13205503)

“…These results provide a blueprint for designing autonomous small robots using phase-separated droplets, which change the mobility and molecular distribution within the droplet in reaction with the environment. …”

Data_Sheet_4_Resolvin E1-ChemR23 Axis Regulates the Hepatic Metabolic and Inflammatory Transcriptional Landscape in Obesity at the Whole Genome and Exon Level.XLSX by Abrar E. Al-Shaer (6580940)

“…Notably, obese WT mice relative to lean controls showed a robust decrease in pathways related to the biosynthesis of unsaturated fatty acids. …”

Updated Emission Factors from Diffuse Combustion Sources in Sub-Saharan Africa and Their Effect on Regional Emission Estimates by David J. Pfotenhauer (6708245)

“…Combining our results with other recent in-field emission factors for rural Ghana, we explored updated emission estimates for Ghana using a region specific emissions inventory. Large differences are calculated for all updated source emissions, showing a 96% increase in OC and 78% decrease in EC compared to prior estimates for Ghana’s emissions. …”

Expression of Lin28B associated with stemness markers in HCC cells. by Shu-Wen Cheng (484650)

“…<p>Western blot analyses showed that Lin28B was overexpressed in captured EpCAM⁺ PLC/PRF/5 cells and Huh-7 cells but not in EpCAM⁺ HepG2 cells (A, upper panel). EpCAM⁺ PLC/PRF/5 cells demonstrated elevated levels of SOX2, Nanog and OCT4; EpCAM⁺ Huh-7 cells, SOX2 and OCT4; but EpCAM⁺ HepG2 cells, none (A, lower panel). …”

Data_Sheet_9_Resolvin E1-ChemR23 Axis Regulates the Hepatic Metabolic and Inflammatory Transcriptional Landscape in Obesity at the Whole Genome and Exon Level.DOCX by Abrar E. Al-Shaer (6580940)

“…Notably, obese WT mice relative to lean controls showed a robust decrease in pathways related to the biosynthesis of unsaturated fatty acids. …”

Table 1_Blastocystis infection in Tibetan antelopes (Pantholops hodgsonii) alters gut microbiota composition and function.xlsx by Jian Liu (33711)

“…Functional profiling showed a decrease in metabolic diversity, with 18 CAZy families detected in the healthy group but only 2 in the infected group. …”

Data_Sheet_1_National situation, trends, and predictions of disease burden of atopic dermatitis in Chinese children and adolescents.docx by Yang Guo (399435)

“…The prediction analyses found a slight decreasing trend for cases of these measures and a slight increasing trend for rates of these measures in the <5 years group in the next 10 years; the 5–9 years group was predicted to increase slightly in rates of the three measures.…”

Image2_TCR-Induced Tyrosine Phosphorylation at Tyr270 of SUMO Protease SENP1 by Lck Modulates SENP1 Enzyme Activity and Specificity.JPEG by Yun-Yi Li (12031955)

“…Through in vivo isopeptidase activity analysis by rescue expression of SENP1 and its Y270 mutants in a SENP1 CRISPR knockout T cell line, we found that SENP1 Y270F downregulated its isopeptidase activity towards both SUMO1 and SUMO2/3 conjugation by reducing SENP1 binding with sumoylated targets. …”