Analysis of SMN levels in different tissues of severe SMA mice. by Francesca Gabanella (34598)

“…<p>(A) Western blot analysis of total proteins from spinal cord, brain or kidney of normal (<i>SMN2</i>^+/+;<i>mSmn</i>^+/+), carrier (<i>SMN2</i>^+/+;<i>mSmn</i>^+/−) and severe SMA (<i>SMN2</i>^+/+;<i>mSmn</i>^−/−) mice at postnatal day 3. …”

Image_1_Transient Inhibition of mTORC1 Signaling Ameliorates Irradiation-Induced Liver Damage.TIF by Wuping Yang (5209310)

“…The results showed that 8.0 Gy of irradiation resulted in hepatocyte edema, hemorrhage, and sinusoidal congestion along with a decrease of ALB expression. Exposure of mice to irradiation significantly activated the mTORC1 signaling pathway determined by pS6 and p-mTOR expression via western blot and immunostaining. …”

Table_1_Integrated Isoform Sequencing and Dynamic Transcriptome Analysis Reveals Diverse Transcripts Responsible for Low Temperature Stress at Anther Meiosis Stage in Rice.xlsx by Zhaojun Qu (9012878)

“…We performed RNA-seq and ISO-seq experiments to study the genome-wide transcript expression profiles in low-temperature anthers. A total of 4,859 differentially expressed transcripts were detected between the low-temperature and control groups. …”

Quantitative Label-Free Phosphoproteomics Reveals Differentially Regulated Protein Phosphorylation Involved in West Nile Virus-Induced Host Inflammatory Response by Hao Zhang (15339)

“…Our results provide a better understanding of the host response to WNV infection and highlight multiple targets for the development of antiviral and anti-inflammatory therapies.…”

Modulation of Glucose Transporter 1 (GLUT1) Expression Levels Alters Mouse Mammary Tumor Cell Growth In Vitro and In Vivo by Christian D. Young (211228)

“…We hypothesized that reducing or eliminating the expression of the most prominently expressed glucose transporter(s) would decrease the amount of glucose available to breast cancer cells thereby decreasing their metabolic capacity and proliferative potential.…”

DataSheet_1_Pro-Inflammatory Signature in Decidua of Recurrent Pregnancy Loss Regardless of Embryonic Chromosomal Abnormalities.pdf by Zaigui Wu (10307435)

“…However, CD11c^high NK and CD161^highCD8⁺ T cells increased only in RPL with normal chromosome, while the inactivated and naive CD8⁺/CD4⁺ T cells were enriched only in RPL with chromosomal aberrations. A pro-inflammatory signature is observed in RPL decidua; however, differences exist between RPL with and without chromosomal abnormalities.…”

Table_1_Activation of farnesoid X receptor suppresses ER stress and inflammation via the YY1/NCK1/PERK pathway in large yellow croaker (Larimichthys crocea).DOCX by Jianlong Du (9295559)

“…Croaker NCK1 was then confirmed to be a regulator of PERK, and its expression in macrophages is increased by FXR overexpression and decreased by FXR knockdown. …”

Convallatoxin suppresses osteosarcoma cell proliferation, migration, invasion, and enhances osteogenic differentiation by downregulating parathyroid hormone receptor 1 (PTHR1) expr... by Xin Liu (43569)

“…<p>Osteosarcoma (OS) is the most common primary malignant bone tumor in children and adolescents. Convallatoxin, a natural cardiac glycoside, exhibits potent anti-tumor activities. …”

Supplementary Material for: Resveratrol Inhibits Neointimal Growth after Arterial Injury in High-Fat-Fed Rodents: The Roles of SIRT1 and AMPK by Guo J. (4144114)

MiR-210 regulates ISCU expression in MCF7 cells. by Elena Favaro (249908)

“…<p><i>A</i>, miR-210 increases under hypoxia, with the most robust induction seen at 48 hrs with 0.1% oxygen. …”

The formation of surface-induced intermediate precedes the loss of native subunit conformation. by Jian-Min Lv (5324774)

“…After brief washes, the immobilized proteins were further incubated for 0–2 h followed by antigenicity detection with 3H12 (A), 8C10 (B), 8D8 (C) or 1D6 (D). To increase the time resolution, the 1-h BSA blocking step before mAb addition was omitted in this series of experiment with only marginal increase in the background signal. …”

Table 1_Inhibition of the MyD88 signaling pathway could upregulates Ghrelin expression to synergistically regulate hepatic Echinococcus multilocularis-infected progression.xlsx by Jiang Zhu (40858)

“…Additionally, we administered the MyD88 inhibitor TJ-M2010-5 intraperitoneally to infected mice to evaluate alterations in inflammation and Ghrelin levels, as well as disease progression.</p>Results<p>A decrease in serum Ghrelin levels in AE patients, whereas both Ghrelin and GHSR, along with TLR4/MyD88/NF-κB pathway proteins and markers of M1/M2 macrophage polarization, exhibited increased expression in the inflammatory cell zones surrounding hepatic lesions. …”

Table_1_Plasma tissue factor coagulation activity in post-acute myocardial infarction patients.docx by Xiong Chang Lim (13848637)

microRNA-21 Governs TORC1 Activation in Renal Cancer Cell Proliferation and Invasion by Nirmalya Dey (145124)

“…Finally, we demonstrate that expression of constitutively active TORC1 attenuated miR-21 Sponge-mediated suppression of proliferation and migration of renal cancer cells. Our results uncover a layer of post-transcriptional regulation of PTEN by transcriptional activation of miR-21 to force the canonical oncogenic Akt/TORC1 signaling conduit to drive renal cancer cell proliferation and invasion.…”

Image_4_Association of Increased Circulating Acetic Acid With Poor Survival in Pseudomonas aeruginosa Ventilator-Associated Pneumonia Patients.tif by Xiaoling Qi (5564066)

“…</p>Results<p>We developed a partial least squares discriminant analysis (PLS-DA) model to examine differential SCFAs in 49 patients with PA-VAP. …”

DataSheet1_Genetic association of hypertension and several other metabolic disorders with Bell’s palsy.docx by Huawei Liu (2585974)

“…</p><p>Conclusion: Hypertension might be a risk factor for Bell’s palsy at the genetic level, and LDL cholesterol might reduce the risk of the disease. …”

Data_Sheet_1_Chinese Black Truffle (Tuber indicum) Alters the Ectomycorrhizosphere and Endoectomycosphere Microbiome and Metabolic Profiles of the Host Tree Quercus aliena.DOCX by Qiang Li (8118)

“…We observed an increase in the diversity and richness of prokaryotic communities and a decrease in richness of fungal communities in the presence of T. indicum. …”

Costs of treating serious adverse effects of drugs used for treatment of obesity: comparison of selected European countries by Branislava Raičević (20102929)

“…Our research aimed to define the health care utilization pattern in treating ADRs of antiobesity therapy, to compare the costs of treating these ADRs among selected European countries, and to identify the key cost drivers. A comparative analysis of the costs of treating the ADRs of antiobesity drugs in 10 European countries (seven EU members and three from the Western Balkans) was conducted, and the impact of parameters of global health expenditures on them was assessed. …”

Quantitative Label-Free Phosphoproteomics Reveals Differentially Regulated Protein Phosphorylation Involved in West Nile Virus-Induced Host Inflammatory Response by Hao Zhang (15339)

“…Our results provide a better understanding of the host response to WNV infection and highlight multiple targets for the development of antiviral and anti-inflammatory therapies.…”

Table 1_Southward shift of winter wheat area intensifies regional water scarcity in the Beijing-Tianjin-Hebei region.docx by Qi Yan (287702)

“…Our findings reveal three distinct phases in wheat planting area changes, characterized by initial increase, subsequent decrease, and eventual stabilization. The southward shift in spatial distribution, evidenced by a 58-km migration of the planting centroids, led to significant water resource disparities. …”