DataSheet_1_Lomerizine inhibits LPS-mediated neuroinflammation and tau hyperphosphorylation by modulating NLRP3, DYRK1A, and GSK3α/β.pdf by Jin-Hee Park (732531)

“…Introduction<p>Lomerizine is a calcium channel blocker that crosses the blood–brain barrier and is used clinically in the treatment of migraines. …”

Data_Sheet_4_Alternative Mating Tactics in Socially Monogamous Prairie Voles, Microtus ochrogaster.pdf by Stephen M. Shuster (629138)

“…In prairie voles, Microtus ochrogaster, a species widely known for forming monogamous pair-bonds, the expression of territoriality within each sex is dimorphic, and includes non-territorial “wanderers” as well as territorial “residents.” …”

Data_Sheet_3_Alternative Mating Tactics in Socially Monogamous Prairie Voles, Microtus ochrogaster.xlsx by Stephen M. Shuster (629138)

“…In prairie voles, Microtus ochrogaster, a species widely known for forming monogamous pair-bonds, the expression of territoriality within each sex is dimorphic, and includes non-territorial “wanderers” as well as territorial “residents.” …”

RTA 408, A Novel Synthetic Triterpenoid with Broad Anticancer and Anti-Inflammatory Activity by Brandon L. Probst (727964)

“…Here, we characterized the in vitro antioxidant, anti-inflammatory, and anticancer activities of RTA 408, a novel AIM that is currently being evaluated in patients with advanced malignancies. …”

DataSheet_1_IL-17A Increases Doxorubicin Efficacy in Triple Negative Breast Cancer.pdf by Nicholas R. Hum (12563075)

“…Furthermore, transcriptional profiles of tumor infiltrated T cells in DOX responsive tumors revealed decreased exhaustion, increased chemokine/cytokine expression, and increased activation and cytotoxic activity. γδ T cell derived IL-17A was identified to be highly abundant in the sensitive tumor microenvironment. …”

Image_1_GM-CSF-activated STAT5A regulates macrophage functions and inflammation in atherosclerosis.png by Jan Nagenborg (14771194)

“…These changes could partially be confirmed at functional level, with significant increases in apoptosis and decreases in lipid uptake and IL-6, IL-8, and TNFa cytokine secretion after STAT5A knockdown. …”

HIV-Tat regulates macrophage gene expression in the context of neuroAIDS by Loreto Carvallo (4167607)

“…We found that HIV Tat increased expression of C5, APBA1, and BDNF, and decreased CRLF2. The K50A Tat-mutation dysregulated expression of these genes without affecting the binding of the Tat complex to their gene sequences. …”

Image_2_Rap1 Is Essential for B-Cell Locomotion, Germinal Center Formation and Normal B-1a Cell Population.jpeg by Sayaka Ishihara (538809)

“…In mice having B-cell-specific Rap1a/b double knockouts (DKO), the number of B cells in lymph nodes decreased to approximately 4% of that of control mice, and B cells were present in the spleen and blood. …”

Lysine Mutation of the Claw-Arm-Like Loop Accelerates Catalysis by Cellobiohydrolases by Zhiyou Zong (7336904)

“…Searching for viable strategies to accelerate the catalytic cycle of glycoside hydrolase family 7 (GH7) cellobiohydrolase I (CBHI)the workhorse cellulose-degrading enzymes, we have performed a total of 12-μs molecular dynamics simulations on GH7 CBHI, which brought to light a new mechanism for cellobiose expulsion, coined “claw-arm” action. …”

Image_1_Rap1 Is Essential for B-Cell Locomotion, Germinal Center Formation and Normal B-1a Cell Population.jpg by Sayaka Ishihara (538809)

“…In mice having B-cell-specific Rap1a/b double knockouts (DKO), the number of B cells in lymph nodes decreased to approximately 4% of that of control mice, and B cells were present in the spleen and blood. …”

Image_8_GM-CSF-activated STAT5A regulates macrophage functions and inflammation in atherosclerosis.png by Jan Nagenborg (14771194)

“…These changes could partially be confirmed at functional level, with significant increases in apoptosis and decreases in lipid uptake and IL-6, IL-8, and TNFa cytokine secretion after STAT5A knockdown. …”

Table_1_GM-CSF-activated STAT5A regulates macrophage functions and inflammation in atherosclerosis.docx by Jan Nagenborg (14771194)

“…These changes could partially be confirmed at functional level, with significant increases in apoptosis and decreases in lipid uptake and IL-6, IL-8, and TNFa cytokine secretion after STAT5A knockdown. …”

DataSheet_1_Complement C3 and Activated Fragment C3a Are Involved in Complement Activation and Anti-Bacterial Immunity.pdf by Meng Wu (191457)

“…<p>In the complement system, C3 is a central component in complement activation, immune defense and immune regulation. …”

Image_4_GM-CSF-activated STAT5A regulates macrophage functions and inflammation in atherosclerosis.png by Jan Nagenborg (14771194)

“…These changes could partially be confirmed at functional level, with significant increases in apoptosis and decreases in lipid uptake and IL-6, IL-8, and TNFa cytokine secretion after STAT5A knockdown. …”

Data_Sheet_1_Physical and Physiological Match-Play Demands and Player Characteristics in Futsal: A Systematic Review.pdf by Konstantinos Spyrou (1560277)

“…<p>Futsal, also known as five-a-side indoor soccer, is a team-sport that is becoming increasingly popular. …”

Lysine 50 of Tat regulates expression of C5, CRLF2, APBA1, and BDNF genes. by Loreto Carvallo (4167607)

“…<p>THP-1Tat-Flag and THP-1Tat K50ATat-Flag cell lines (generated from independent experiments described in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0179882#pone.0179882.g005" target="_blank">Fig 5</a>) were differentiated to macrophages with PMA for 24 and 48 hours. …”

Structure-Based Design, Synthesis, and Biological Evaluation of New Triazolo[1,5‑<i>a</i>]Pyrimidine Derivatives as Highly Potent and Orally Active ABCB1 Modulators by Shuai Wang (109515)

“…ABCB1 is a promising therapeutic target for overcoming multidrug resistance (MDR). …”

DataSheet_1_Circulating methylation level of HTR2A is associated with inflammation and disease activity in rheumatoid arthritis.pdf by Jianan Zhao (9516635)

“…Objectives<p>HTR2A is previously identified as a susceptibility gene for rheumatoid arthritis (RA). …”

Structure-Based Design, Synthesis, and Biological Evaluation of New Triazolo[1,5‑<i>a</i>]Pyrimidine Derivatives as Highly Potent and Orally Active ABCB1 Modulators by Shuai Wang (109515)

“…ABCB1 is a promising therapeutic target for overcoming multidrug resistance (MDR). …”

DataSheet_1_METTL3 inhibits inflammation of retinal pigment epithelium cells by regulating NR2F1 in an m6A-dependent manner.docx by Jiayu Meng (13131456)

“…<p>N⁶-metyladenosine (m⁶A) RNA methylation has been proven to be involved in diverse biological processes, but its potential roles in the development of lipopolysaccharide (LPS) induced retinal pigment epithelium (RPE) inflammation have not been revealed. …”