Image2_HR-MS Based Untargeted Lipidomics Reveals Characteristic Lipid Signatures of Wilson’s Disease.TIF by Yixiao Zhi (11736269)

“…<p>Background and Aims: The diagnosis of Wilson’s disease (WD) is challenging by clinical or genetic criteria. A typical early pathological change of WD is the increased liver lipid deposition and lowered serum triglyceride (TG). …”

Graphene and Rice-Straw-Fiber-Based 3D Photothermal Aerogels for Highly Efficient Solar Evaporation by Daniel Peter Storer (8595018)

“…The photothermal aerogel shows a strong broad-band light absorption of 96–97%. …”

Image_1_Identification of subclusters and prognostic genes based on glycolysis/gluconeogenesis in hepatocellular carcinoma.tif by Dan Chen (32468)

“…The study also identified five intersecting DEGs from candidate genes in TCGA, GSE14520, and GSE141198 as prognostic genes, which had a protective role in HCC patient prognosis. Compared with the control group, the prognostic genes all showed decreased expression in HCC patients in RT-qPCR and Western blot analyses. …”

Aging- and obesity-related peri-muscular adipose tissue accelerates muscle atrophy by Shunshun Zhu (7305401)

“…<div><p>Sarcopenia due to loss of skeletal muscle mass and strength leads to physical inactivity and decreased quality of life. The number of individuals with sarcopenia is rapidly increasing as the number of older people increases worldwide, making this condition a medical and social problem. …”

Maternal obese-type gut microbiota differentially impact cognition, anxiety and compulsive behavior in male and female offspring in mice by Annadora J. Bruce-Keller (311161)

“…Collectively, these data establish that high fat diet-induced maternal dysbiosis is sufficient to disrupt behavioral function in murine offspring in a sex-specific manner. Thus these data reinforce the essential link between maternal diet and neurologic programming in offspring and suggest that intestinal dysbiosis could link unhealthy modern diets to the increased prevalence of neurodevelopmental and childhood disorders.…”

Preventing Protein Oxidation with Sugars: Scavenging of Hypohalous Acids by 5‑Selenopyranose and 4‑Selenofuranose Derivatives by Corin Storkey (1820602)

“…These studies demonstrate that novel selenium (and to a lesser extent, sulfur) derivatives of monosaccharides could be potent modulators of peroxidase-mediated damage at sites of acute and chronic inflammation, and in multiple human pathologies.…”

Image 4_An analysis of the global burden of gallbladder and biliary tract cancer attributable to high BMI in 204 countries and territories: 1990–2021.tif by Zhuowen Hu (20431616)

“…High Body Mass Index (BMI) is a significant risk factor, contributing substantially to GBTC mortality and Disability-Adjusted Life Years (DALYs). …”

Image_5_Risk stratification based on DNA damage-repair-related signature reflects the microenvironmental feature, metabolic status and therapeutic response of breast cancer.tif by Chunzhen Li (14835418)

“…Integrating public datasets and bioinformatics algorithms, we developed a robust prognostic signature based on 27 DRGs. …”

Image_1_Polysaccharides From Chrysanthemum morifolium Ramat Ameliorate Colitis Rats via Regulation of the Metabolic Profiling and NF-κ B/TLR4 and IL-6/JAK2/STAT3 Signaling Pathways... by Jin-Hua Tao (5496602)

“…Meanwhile, the elevated expression levels of pp65, TLR4, p-STAT3, and p-JAK2 were significantly decreased after treatment. Results suggested that CP would be a potential prebiotics for alleviation of TNBS-induced colitis. …”

DataSheet_5_BRAFV600E Mutation-Responsive miRNA-222-3p Promotes Metastasis of Papillary Thyroid Cancer Cells via Snail-Induced EMT.zip by Yuan Gao (159945)

“…Inhibition of miR-222-3p significantly suppressed the migration of B-CPAP and induced a mesenchymal-epithelial transition (MET) phenotype via the Snail transcription factor. …”

Image_6_The Interaction Mechanism Between Herpes Simplex Virus 1 Glycoprotein D and Host Antiviral Protein Viperin.jpg by Meili Li (286549)

“…<p>Viperin is an interferon-inducible protein that responsible for a variety of antiviral responses to different viruses. …”

Table1_Landscape of immune infiltration in entorhinal cortex of patients with Alzheimerʼs disease.XLSX by Hui Zhang (7197)

“…Taken together, these results delineate the profile of the immune components of the entorhinal cortex in Alzheimer’s diseases, providing a new perspective on the development and treatment of Alzheimer’s disease.…”

Data_Sheet_2_Molecular Features of Polycystic Ovary Syndrome Revealed by Transcriptome Analysis of Oocytes and Cumulus Cells.docx by Jie Li (15030)

“…<p>Polycystic ovary syndrome (PCOS) is typically characterized by a polycystic ovarian morphology, hyperandrogenism, ovulatory dysfunction, and infertility. …”

DataSheet7_Single-cell transcriptome dynamics of the autotaxin-lysophosphatidic acid axis during muscle regeneration reveal proliferative effects in mesenchymal fibro-adipogenic pr... by Osvaldo Contreras (780538)

“…<p>Lysophosphatidic acid is a growth factor-like bioactive phospholipid recognising LPA receptors and mediating signalling pathways that regulate embryonic development, wound healing, carcinogenesis, and fibrosis, via effects on cell migration, proliferation and differentiation. …”

DataSheet_3_SCM-198 Prevents Endometriosis by Reversing Low Autophagy of Endometrial Stromal Cell via Balancing ERα and PR Signals.zip by Yi-Kong Lin (12882812)

“…</p>Results<p>Increased estrogen-estrogen receptor (ER) α signaling and decreased progesterone receptor isoform B (PRB) expression synergistically led to a hypo-autophagy state in eESCs, which further inhibited the apoptosis of eESCs. …”

Fasudil Protects the Heart against Ischemia-Reperfusion Injury by Attenuating Endoplasmic Reticulum Stress and Modulating SERCA Activity: The Differential Role for PI3K/Akt and JAK... by Yapeng Li (124282)

“…In the present study, using fasudil which is a specific inhibitor of ROCK, we aimed to investigate whether improved SERCA expression and activity accounts for reduced ER stress by ROCK inhibition, specifically whether PI3K/Akt and JAK2/STAT3 pathways are differentially involved in modulating SERCA activity to reduce ER stress and hence I/R injury. …”

Image_7_Wheat F-box Protein TaFBA1 Positively Regulates Plant Drought Tolerance but Negatively Regulates Stomatal Closure.tif by Jie An (543888)

“…In addition, TaFBA1 was found to be a negative regulator of ABA-induced stoma movement; mRNA transcription of certain ABA signaling-related genes was lower in TaFBA1 OE plants than in WT plants following ABA treatment. …”

CB2R inhibits the production of IL-1β but not IL-6 and TNF-α in cultured peritoneal macrophages stimulated with LPS/DSS. by Ping Ke (3110763)

“…The levels of IL-1β, IL-6 and TNF-α were measured by ELISA. (A-C) Pre-incubated with HU 308 significantly decreased the level of IL-1β but have no effect on the levels of IL-6 and TNF-α. n = 6 per group. …”

<i>Foxo</i> mediates the effects of <i>PI3K</i> on motor neuron excitability. by Eric Howlett (268817)

“…For all LTF experiments, the bath solution contained 0.15 mM [Ca²⁺] and 100 µM quinidine. A) Representative traces showing the decreased rate of onset of LTF (I) and decreased ejp amplitude (II) in <i>Foxo²¹/Foxo²⁵</i> larvae compared to wildtype at the indicated [Ca²⁺], and the increased rate of onset of LTF and ejp amplitude in larvae overexpressing <i>Foxo</i>. …”

Quantitative scoring of collagen II, MMP-13 and ICAM-1 immunohistochemistry. by Julia Lorenz (626379)

“…<p>Medial parts of frontal sections of right knee joints from WT and Mc1re/e mice of non-operated (non-op) 11 weeks old and 6 months old animals, and of mice 4 and 8 weeks after osteoarthritis induction (post operation (p.o.)) were scored after staining. 1-3 sections of right knees (DMM) were scored histological according to the scoring system illustrated in Tab. 1 for collagen II, in Tab. 2 for MMP-13 and in Tab. 3 for ICAM-1 staining. A) Compared to non-operated controls collagen II stained cartilage area of WT knee joints is decreased 4 weeks (p = 0.0079) and 8 weeks (p = 0.0043) after OA-induction as well as in non-operated 6 month old animals (p = 0.0159). …”