Image_2_Surfactant Protein D Deficiency Aggravates Cigarette Smoke-Induced Lung Inflammation by Upregulation of Ceramide Synthesis.TIF by Bartosz Pilecki (3091188)

“…Here, we investigated the role of SP-D in a murine model of CS-induced inflammation. Pulmonary SP-D localization and abundance was compared between smoker and non-smoker individuals. …”

Image_1_Exopolysaccharide-producing bacteria enhanced Pb immobilization and influenced the microbiome composition in rhizosphere soil of pakchoi (Brassica chinensis L.).pdf by Ruiwen Cao (5507192)

“…The potential of Pseudoalteromonas agarivorans Hao 2018, a high EPS-producing marine bacterium, to produce EPS in soil filtrate, immobilize Pb, and inhibit its uptake by pakchoi (Brassica chinensis L.) was studied in this work. …”

HSP70 mediates phosphorylation of AKT, p38, JNK and ERK1/2 in CD4⁺CD25⁺ T cells and suppressive capacity of these cells could be influenced by the respective... by Julian Wachstein (109892)

“…Phosphorylation for intracellular kinases (<b>A</b>) phospo-AKT [p-AKT Ser⁴⁷³], (<b>B</b>) phospo-JNK [p-JNK Thr¹⁸³/Tyr¹⁸⁵], (<b>C</b>) phospo-p38 MAPK [p-p38 MAPK Thr¹⁸⁰/Tyr¹⁸²] and (<b>D</b>) phospo-ERK1/2 [p-ERK1/2 Thr²⁰²/Tyr²⁰⁴/Thr¹⁸⁵/Tyr¹⁸⁷] was determined by the bead-based multiplex assay (Luminex xMAP technology). …”

Image_2_Alteration of Intestinal Microbiota Composition in Oral Sensitized C3H/HeJ Mice Is Associated With Changes in Dendritic Cells and T Cells in Mesenteric Lymph Nodes.jpg by Cui Zhou (1388874)

“…The intestinal bacterial community structure was analyzed, followed by Spearman correlation analysis between changed gut microbiota species and allergic parameters. Sensitization induced a noticeable allergic response to the gavage of OVA without adjuvant. …”

Data_Sheet_1_Single-cell transcriptome revealed dysregulated RNA-binding protein expression patterns and functions in human ankylosing spondylitis.ZIP by Zheng Ren (1766506)

“…</p>Results<p>(1) Compared with the HC group, the numbers of B, DC (dendritic cells), CD14⁺ Mono and CD8⁺ T cells were increased in AS group, while the numbers of platelet (platelets), CD8⁺ NKT, CD16⁺ Mono (non-classical monocytes), Native CD4⁺ T and NK were decreased. (2) Through the analysis of RBP genes in B cells, some RBPs were found to play an important role in B cell differentiation and function, such as DDX3X, SFPQ, SRRM1, UPF2. (3) It may be related to B-cell receptor, IgA immunity, NOD-like receptor and other signaling pathways; Through the analysis of RBP genes in CD8⁺ T cells, some RBPs that play an important role in the immune regulation of CD8⁺ T were found, such as EIF2S3, EIF4B, HSPA5, MSL3, PABPC1 and SRSF7; It may be related to T cell receptor, TNF, IL17 and other signaling pathways. (4) Based on bulk RNA-seq, it was found that compared with HC and AS patients, differentially expressed variable splicing genes (RASGs) may play an important role in the occurrence and development of AS by participating in transcriptional regulation, protein phosphorylation and ubiquitination, DNA replication, angiogenesis, intracellular signal transduction and other related pathways.…”

Loss of PRAS40 prevents cell demise, improves EPO cytoprotection, and increases phosphorylation of mTOR, p70S6K, and 4EBP1. by Zhao Zhong Chong (307295)

“…<p>(<b>A</b>) Representative images of trypan blue (TB) dye staining and TUNEL assay performed 24 hours following OGD exposure in SH-SY5Y cells show that PRAS40 siRNA transfection prior to OGD significantly reduced trypan blue and TUNEL staining and mildly improved cytoprotection by EPO (10 ng/ml) applied 1 hour prior to OGD. …”

Data_Sheet_1_Antenatal Endotoxin Impairs Lung Mechanics and Increases Sensitivity to Ventilator-Induced Lung Injury in Newborn Rat Pups.pdf by Erica W. Mandell (9979040)

“…We speculate that antenatal inflammation primes the lung for a more marked VILI response, suggesting an adverse synergistic effect of antenatal and postnatal exposures.…”

Image1_Impact of in Utero Rat Exposure to 17Alpha-Ethinylestradiol or Genistein on Testicular Development and Germ Cell Gene Expression.JPEG by Laetitia L. Lecante (12716315)

“…Here, we took advantage of a transgenic rat expressing the green fluorescent protein specifically in germ cells allowing purification of perinatal GFP-positive germ cells. …”

MyD88-dependent inflammasome activation and autophagy inhibition contributes to <i>Ehrlichia</i>-induced liver injury and toxic shock by Muhamuda Kader (437247)

“…<div><p>Severe hepatic inflammation is a common cause of acute liver injury following systemic infection with <i>Ehrlichia</i>, obligate Gram-negative intracellular bacteria that lack lipopolysaccharide (LPS). …”

Vitexin attenuates lipopolysaccharide-induced acute lung injury by controlling the Nrf2 pathway by Ying Lu (66401)

“…<div><p>Background</p><p>A major feature of acute lung injury (ALI) is excessive inflammation in the lung. …”

Table_1_Longitudinal Cytokine Profile in Patients With Mild to Critical COVID-19.xlsx by Lowell Ling (8433594)

“…The secondary objective was to assess the associations between cytokines and clinical endpoints in critically ill patients. A total of 40 adult patients (mild = 8, moderate = 15, severe/critical = 17) hospitalized with COVID-19 were included in this study. …”

DataSheet7_Guanxinkang Decoction Attenuates the Inflammation in Atherosclerosis by Regulating Efferocytosis and MAPKs Signaling Pathway in LDLR−/− Mice and RAW264.7 Cells.xlsx by Yifan Zhang (119570)

“…<p>Guanxinkang decoction (GXK), a traditional Chinese medicinal drug, is used to treat cardiovascular disease. …”

Supplementary Material for: Gintonin Attenuates D-Galactose-Induced Hippocampal Senescence by Improving Long-Term Hippocampal Potentiation, Neurogenesis, and Cognitive Functions by Nam S.M. (5678177)

“…However, little is known about the ingredients of ginseng and molecular mechanisms of its anti-brain aging effects. Gintonin is a novel exogenous ginseng-derived lysophosphatidic acid (LPA) receptor ligand; LPA and LPA1 receptors are involved in adult hippocampal neurogenesis. …”

Image_2_Reversal of Endothelial Extracellular Vesicle-Induced Smooth Muscle Phenotype Transition by Hypercholesterolemia Stimulation: Role of NLRP3 Inflammasome Activation.tiff by Xinxu Yuan (7446968)

“…Moreover, acid ceramidase (AC) deficiency or lysosome inhibition further exaggerated the 7-Ket-induced release of IL-1β-containing EVs in ECs. Using a Western diet (WD)-induced hypercholesterolemia mouse model, we found that endothelial-specific AC gene knockout mice (Asah1^fl/fl/EC^Cre) exhibited augmented WD-induced EV secretion with IL-1β and more significantly decreased the interaction of MVBs with lysosomes in the carotid arterial wall compared to their wild-type littermates (WT/WT). …”

Image_2_Macrophages-Related Genes Biomarkers in the Deterioration of Atherosclerosis.TIFF by Yue Zheng (601811)

“…The hub DEMRGs and their interactions were analyzed using NetworkAnalyst 3.0 and for validation, the expressions of hub DEMRGs were analyzed using the GSE135055 and GSE116250 datasets as well as atherosclerosis and MI mice model.</p>Results<p>A total of 509 differentially expressed genes (DEGs) were correlated with the abundance of macrophages and were identified as DEMRGs (Pearson correlation coefficients (PCC) > 0.6), which were mainly enriched in extracellular structure organization, lysosomal membrane, MHC protein complex binding, and so on. …”

DataSheet1_Comprehensively prognostic and immunological analyses of GLP-1 signaling-related genes in pan-cancer and validation in colorectal cancer.docx by Chaojun Zhu (11711609)

“…</p><p>Conclusion: This study provided a preliminary understanding of the GLP-1 signaling-related genes in pan-cancer, showing the prognosis significance and potential immunotherapeutic values in most cancer types, and verified the potential anticancer effect of GLP-1 receptor agonist in CRC.…”

DataSheet_1_Antiviral Activity Against Infectious Bronchitis Virus and Bioactive Components of Hypericum perforatum L..docx by Huijie Chen (235980)

“…Moreover, the mainly active compositions of HPE analyzed by high-performance liquid chromatography/electrospray ionization–mass spectroscopy (ESI-MS) are hyperoside, quercitrin, quercetin, pseudohypericin, and hypericin, and a combination of these compounds could mediate the antiviral activities. …”

Image_2_Multi-omics analysis of naïve B cells of patients harboring the C104R mutation in TACI.jpg by Neftali Ramirez (13251924)

“…In steady state, naïve B cells had increased cell death pathways and reduced cell metabolism pathways, while after stimulation, enhanced immune responses and decreased cell survival were detected. Using a multi-omics approach, our findings provide valuable insights into the impaired biology of naïve B cells from TACI mutation carriers.…”

Image_2_Multi-omics analysis of naïve B cells of patients harboring the C104R mutation in TACI.jpg by Neftali Ramirez (13251924)

“…In steady state, naïve B cells had increased cell death pathways and reduced cell metabolism pathways, while after stimulation, enhanced immune responses and decreased cell survival were detected. Using a multi-omics approach, our findings provide valuable insights into the impaired biology of naïve B cells from TACI mutation carriers.…”

Luminescent Pt^II−M^I (M = Cu, Ag, Au) Heteronuclear Alkynyl Complexes Prepared by Reaction of [Pt(C⋮CR)₄]^2- with [M₂(dppm)<sub... by Gang-Qiang Yin (2516491)

“…A series of PtM, PtM₂, and Pt₂M₃ (M = Cu, Ag, Au) heteronuclear alkynyl complexes, synthesized by reaction of the tetraalkynylplatinate(II) complexes [Pt(C⋮CR)₄]^2- with [M₂(<i>μ</i>-dppm)₂]²⁺ (dppm = bis(diphenylphosphino)methane), were characterized by elemental analyses, ESI-MS, ¹H and ³¹P NMR spectroscopy, and X-ray crystallography for <b>5</b>−<b>13</b>. …”