A- and D‑Ring Structural Modifications of an Androsterone Derivative Inhibiting 17β-Hydroxysteroid Dehydrogenase Type 3: Chemical Synthesis and Structure–Activity Relationships... by Francisco Cortés-Benítez (4523380)

“…Decreasing the intratumoral androgen biosynthesis by using an inhibitor of 17β-hydroxysteroid dehydrogenase type 3 (17β-HSD3) is a strategy to treat prostate cancer. …”

Clozapine counteracts a ketamine-induced depression of hippocampal-prefrontal neuroplasticity and alters signaling pathway phosphorylation by Marion Rame (4003157)

“…Among the statistically significant effects that were detected (a) both ketamine and clozapine increased the phosphorylation of Ser9-GSK3β throughout the prefrontal cortex and of Ser2481-mTOR in the dorsal hippocampus (DH), (b) clozapine increased the phosphorylation of Ser831-GluA1 throughout the prefrontal cortex and of Ser845-GluA1 in the ventral hippocampus, (c) ketamine treatment increased the phosphorylation of Thr202/Tyr204-ERK in the medial PFC (mPFC), and (d) clozapine treatment was associated with decreases in the phosphorylation of Tyr705-TrkB in the DH and of Try816-TrkB in the mPFC. …”

Image_1_Lipoxin A4 attenuates MSU-crystal-induced NLRP3 inflammasome activation through suppressing Nrf2 thereby increasing TXNRD2.tif by You Zhou (129411)

“…<p>Gout is a common inflammatory disease. The activation of NLRP3 inflammasome induced by monosodium urate (MSU) crystals has a critical role in gout, and its prevention is beneficial for patients. …”

DataSheet_1_Functional variant rs12614 in CFB confers a low risk of IgA nephropathy by attenuating complement alternative pathway activation in Han Chinese.pdf by Dian-Chun Shi (13951020)

“…<p>Activation of the alternative pathway (AP) of complement is thought to play an important role in Immunoglobin A nephropathy (IgAN). Our previous study showed that rs4151657 within the complement factor B (CFB) gene increased the risk of IgAN. …”

Image_1_Histone H2A Nuclear/Cytoplasmic Trafficking Is Essential for Negative Regulation of Antiviral Immune Response and Lysosomal Degradation of TBK1 and IRF3.tif by Xiao Man Wu (5080451)

“…The in vivo studies revealed that histone H2A overexpression led to the increased expression of SVCV gene and decreased survival rate. …”

DataSheet_1_Functional variant rs12614 in CFB confers a low risk of IgA nephropathy by attenuating complement alternative pathway activation in Han Chinese.pdf by Dian-Chun Shi (13951020)

“…<p>Activation of the alternative pathway (AP) of complement is thought to play an important role in Immunoglobin A nephropathy (IgAN). Our previous study showed that rs4151657 within the complement factor B (CFB) gene increased the risk of IgAN. …”

Data_Sheet_1_Clostridioides difficile Colonization Is Differentially Associated With Gut Microbiome Profiles by Infant Feeding Modality at 3–4 Months of Age.xlsx by Kelsea M. Drall (8112032)

“…EBF infants colonized with C. difficile had an increased relative abundance of Firmicutes and Proteobacteria, decreased relative abundance of Bifidobacteriaceae, greater microbiota alpha-diversity, greater detectable fecal short chain fatty acids (SCFA), and lower detectable fecal secretory Immunoglobulin A (sIgA) than those not colonized. …”

Image_2_Lipoxin A4 attenuates MSU-crystal-induced NLRP3 inflammasome activation through suppressing Nrf2 thereby increasing TXNRD2.tif by You Zhou (129411)

“…<p>Gout is a common inflammatory disease. The activation of NLRP3 inflammasome induced by monosodium urate (MSU) crystals has a critical role in gout, and its prevention is beneficial for patients. …”

Gene Silencing and Haploinsufficiency of <i>Csk</i> Increase Blood Pressure by Hyeon-Ju Lee (796527)

“…We also showed that inhibition of Src by PP2, a Src inhibitor decreased high blood pressure in <i>Csk</i>^+/- mice and the active Src in <i>Csk</i>^+/- mice aorta and in <i>Csk</i> knock-down vascular smooth muscle cells, suggesting blood pressure regulation by Csk through Src.…”

Table_1_Lipoxin A4 attenuates MSU-crystal-induced NLRP3 inflammasome activation through suppressing Nrf2 thereby increasing TXNRD2.doc by You Zhou (129411)

“…<p>Gout is a common inflammatory disease. The activation of NLRP3 inflammasome induced by monosodium urate (MSU) crystals has a critical role in gout, and its prevention is beneficial for patients. …”

Efficacy and safety of saxagliptin in patients with type 2 diabetes: A systematic review and meta-analysis by Peng Men (843311)

“…A complementary search was done to cover literature until March 2018. …”

DataSheet_1_β-Tubulin Isotype, TUBB4B, Regulates The Maintenance of Cancer Stem Cells.pdf by Dhrishya Dharmapal (7318913)

“…Here, we show that the knockdown of TUBB4B downregulates the expression of pluripotency markers, depletes ALDH1A1⁺ population, decreases in vitro sphere formation, and diminishes the tumor initiation potential in vivo. …”

Table1_Deciphering colorectal cancer radioresistance and immune microrenvironment: unraveling the role of EIF5A through single-cell RNA sequencing and machine learning.docx by Yaqi Zhong (19526857)

“…In vivo experiments showed that EIF5A knockdown led to increased infiltration of CD8+ T cells and M1 macrophages, and decreased M2 macrophages and Tregs following radiation therapy, thereby enhancing the radiotherapy response.…”

Image_4_Lipoxin A4 attenuates MSU-crystal-induced NLRP3 inflammasome activation through suppressing Nrf2 thereby increasing TXNRD2.tif by You Zhou (129411)

“…<p>Gout is a common inflammatory disease. The activation of NLRP3 inflammasome induced by monosodium urate (MSU) crystals has a critical role in gout, and its prevention is beneficial for patients. …”

Image_3_Lipoxin A4 attenuates MSU-crystal-induced NLRP3 inflammasome activation through suppressing Nrf2 thereby increasing TXNRD2.tif by You Zhou (129411)

“…<p>Gout is a common inflammatory disease. The activation of NLRP3 inflammasome induced by monosodium urate (MSU) crystals has a critical role in gout, and its prevention is beneficial for patients. …”

DataSheet1_Deciphering colorectal cancer radioresistance and immune microrenvironment: unraveling the role of EIF5A through single-cell RNA sequencing and machine learning.docx by Yaqi Zhong (19526857)

“…In vivo experiments showed that EIF5A knockdown led to increased infiltration of CD8+ T cells and M1 macrophages, and decreased M2 macrophages and Tregs following radiation therapy, thereby enhancing the radiotherapy response.…”

DataSheet1_Neurobehavioral phenotype of Kabuki syndrome: Anxiety is a common feature.docx by Allison J. Kalinousky (13913673)

“…Interestingly, anxiety, a phenotype that has a known association with decreased hippocampal neurogenesis, has been anecdotally reported in individuals with KS. …”

DataSheet_1_Lipoxin A4 attenuates MSU-crystal-induced NLRP3 inflammasome activation through suppressing Nrf2 thereby increasing TXNRD2.doc by You Zhou (129411)

“…<p>Gout is a common inflammatory disease. The activation of NLRP3 inflammasome induced by monosodium urate (MSU) crystals has a critical role in gout, and its prevention is beneficial for patients. …”

BMI groups by SES. by Krystal Hunter (6820052)

“…For every increase in BMI, there was a decrease in the probability of PTB (OR = 0.923, 95% CI 0.915–0.931, P < 0.001). …”

BMISES_Data_Part2. by Krystal Hunter (6820052)

“…For every increase in BMI, there was a decrease in the probability of PTB (OR = 0.923, 95% CI 0.915–0.931, P < 0.001). …”