A Novel Arylurea Fatty Acid That Targets the Mitochondrion and Depletes Cardiolipin To Promote Killing of Breast Cancer Cells by Tristan Rawling (1751023)

“…In mechanistic studies <b>13b</b> emerged as the prototype of a novel class of mitochondrion-targeted agents that deplete cardiolipin and promote cancer cell death.…”

Cortically-evoked response elicited in the silent period (A) and cervicomedullary-evoked response elicited in the silent period (B). by Petra S. Williams (494880)

“…<p>A. The amplitude (% of pre-fatigue baseline) of the motor evoked potential elicited in the silent period (MEP elicited in SP) increased progressively to task failure during both fatigue-tasks in the biceps (*<i>p</i> = 0.01) and the brachioradialis (**<i>p</i> = 0.01). …”

Table_1_The Effect of Controlled Decompression for Severe Traumatic Brain Injury: A Randomized, Controlled Trial.DOC by Junhui Chen (743463)

“…In addition, the patients in the controlled decompression group had a lower intraoperative brain swelling rate (13.3 vs. 24.3%, P = 0.036), a lower delayed hematoma rate (17.7 vs. 29.0%, P = 0.048) and a relatively lower post-traumatic cerebral infarction rate (15.0 vs. 22.4%, P = 0.127) than those in the rapid decompression group.…”

Supplementary data: A value-based budget impact model for dronedarone compared with other rhythm control strategies by Jennifer Ken-Opurum (18359074)

“…Ablation</li><li><b>Supplementary Table 10: </b>Event Risks for Temporal Scenarios</li></ul><p dir="ltr"><b>Aim: </b>The budgetary consequences of increasing dronedarone utilization for treatment of atrial fibrillation were evaluated from a US payer perspective. <b>Materials & methods:</b> A budget impact model over a 5-year time horizon was developed, including drug-related costs and risks for long-term clinical outcomes (LTCOs). …”

<i>DANCR</i> is a clinically important MITF and c-MYC regulated lncRNA in human melanoma. by Stephanie M. E. Jones (12883691)

“…<p><b>(A)</b> UCSC genome browser view showing MITF and c-MYC ChIP-seq peaks across the <i>DANCR</i> locus (GRCh37/hg19). …”

Table_2_Deleterious Variation in BR Serine/Threonine Kinase 2 Classified a Subtype of Autism.docx by Jingxin Deng (11418689)

“…Molecularly, the mRNA expression levels of homer1b (a postsynaptic density scaffolding protein), and mbpa, mpz, and plp1b (molecular markers of oligodendrocytes and myelination) were increased in the brain tissues of adult brsk2b^–/– zebrafish, while the expression level of isl1a, a marker of motor neurons, was decreased. …”

An ice-obligate seabird responds to a multi-decadal decline in Arctic sea ice - population matrix model by George Divoky (17982751)

“…<p>The Arctic has experienced greatly decreased sea ice and increased ocean temperatures in recent decades but there is a paucity of biological time-series data allowing assessment of resulting temporal variation in the region’s marine ecosystems. …”

Supplementary Material for: Anti-Vascular Endothelial Growth Factor Treatment Outcomes in Macular Telangiectasia: A Systematic Review by figshare admin karger (2628495)

“…Purpose: To assess clinical outcomes of anti-vascular endothelial growth factor agents (anti-VEGF) for patients with Macular Telangiectasia (MacTel). Methods: A systematic literature search on Ovid MEDLINE, Embase, and Cochrane Library was performed from inception to June 2024 for comparative studies on anti-VEGF agents in MacTel. …”

A Constructed Alkaline Consortium and Its Dynamics in Treating Alkaline Black Liquor with Very High Pollution Load by Chunyu Yang (269294)

“…After treatment by the constructed consortium, about 35.4% of color and 39,000 mg l⁻¹ (27.3%) COD_cr were removed and the pH decreased to 7.8. 16S rRNA gene polymerase chain reaction denaturant gradient gel electrophoresis (PCR-DGGE) and gas chromatography/mass spectrometry (GC/MS) analysis suggested a two-stage treatment mechanism to elucidate the interspecies collaboration: <em>Halomonas</em> isolates were important in the first stage to produce organic acids that contributed to the pH decline, while <em>Bacillus</em> isolates were involved in the degradation of lignin derivatives in the second stage under lower pH conditions.…”

Supplementary Figures from A First-in-Class TWIST1 Inhibitor with Activity in Oncogene-Driven Lung Cancer by Zachary A. Yochum (15006633)

“…Supplementary Figure 5: Harmine treatment promotes TWIST1 degradation and decreases TWIST1 protein stability. Supplementary Figure 6: Silencing of E2A induces apoptosis and phenocopies silencing of TWIST1. …”

DataSheet_2_Causality of genetically proxied immunophenotypes on cardiovascular diseases: a Mendelian randomization study.docx by Xuehan Wang (10590882)

“…Increased levels of IgD- CD38dim absolute count were associated with a higher susceptibility to AF, while increased expression of CD14+ CD16+ monocytes, CD62L on CD62L+ myeloid dendritic cells, and CD16 on CD14- CD16+ monocytes were linked to a decreased susceptibility to AF. …”

Nitrate and Nitrite Variability at the Seafloor of an Oxygen Minimum Zone Revealed by a Novel Microfluidic In-Situ Chemical Sensor by Mustafa Yücel (5664331)

“…<div><p>Microfluidics, or lab-on-a-chip (LOC) is a promising technology that allows the development of miniaturized chemical sensors. …”

DataSheet_1_Causality of genetically proxied immunophenotypes on cardiovascular diseases: a Mendelian randomization study.xlsx by Xuehan Wang (10590882)

“…Increased levels of IgD- CD38dim absolute count were associated with a higher susceptibility to AF, while increased expression of CD14+ CD16+ monocytes, CD62L on CD62L+ myeloid dendritic cells, and CD16 on CD14- CD16+ monocytes were linked to a decreased susceptibility to AF. …”

An ice-obligate seabird responds to a multi-decadal decline in Arctic sea ice - multistate data file by George Divoky (17982751)

“…<p>The Arctic has experienced greatly decreased sea ice and increased ocean temperatures in recent decades but there is a paucity of biological time-series data allowing assessment of resulting temporal variation in the region’s marine ecosystems. …”

Table_2_Hypoxically Induced Nitric Oxide: Potential Role as a Vasodilator in Mytilus edulis Gills.docx by Paula Mariela González (6422663)

“…<p>Intertidal Mytilus edulis experience rapid transgression to hypoxia when they close their valves during low tide. This induces a physiological stress response aiming to stabilize tissue perfusion against declining oxygen partial pressure in shell water. …”

Altered Behavioral Performance and Live Imaging of Circuit-Specific Neural Deficiencies in a Zebrafish Model for Psychomotor Retardation by David Zada (634499)

“…Time-lapse imaging of single-axon arbors and synapses in live <i>mct8</i>−/− larvae revealed a reduction in filopodia dynamics and axon branching in sensory neurons and decreased synaptic density in motor neurons. …”

Data_Sheet_1_Uric Acid as a Potential Peripheral Biomarker for Disease Features in Huntington’s Patients.pdf by Jody Corey-Bloom (610437)

“…Finally, in a separate cohort, we show that UA levels are decreased in postmortem prefrontal cortical samples (n = 20) from HD subjects compared to matched controls. …”

Supplementary Material for: Characterisation of an ischaemia-reperfusion model for the formation of a stage II pressure injury in diabetic mice by figshare admin karger (2628495)

“…On day 10, db/db mice exhibited delayed wound closure, as well as impaired regeneration of the panniculus carnosus and dermis, with significantly decreased mRNA levels of VEGF and HSP90. Conclusion: Ischaemia lasting 4 h is the appropriate duration for generating stage II pressure injuries in diabetic mice, which may be applicable to generate a reproducible model of stage II pressure injury caused by ischaemia-reperfusion injury. …”

Common core structures were cytotoxic to cancer cells in part through a p53-dependent mechanism. by John Bechill (2636539)

“…<p>(A) Compounds sharing the common core structure caused decreased viability in the cancer cell lines HeLa, siHA, and C33a. …”

Supplementary Material for: Herpes Zoster and Subsequent Cancer Risk: A Nationwide Population-Based Cohort Study in Korea by Kim M. (4125505)

“…<b><i>Background:</i></b> It is well known that an immunosuppressed status such as cancer is a risk factor for herpes zoster (HZ), but little is known about whether HZ affects cancer development. …”