MDR1A deficiency restrains tumor growth in murine colitis-associated carcinogenesis by Eva Maria Hennenberg (4234018)

“…We investigated the consequences of ABCB1/MDR1 loss-of-function in a common murine model for CAC (AOM/DSS). Mice deficient in MDR1A (MDR1A KO) showed enhanced intratumoral inflammation and cellular damage, which were associated with reduced colonic tumor size and decreased degree of dysplasia, when compared to wild-type (WT). …”

MicroRNA expression profile in retina and choroid in oxygen-induced retinopathy model by Michel Desjarlais (6832442)

“…During OIR-induced vessel degeneration phase, miR-199a-3p, -199a-5p, -1b, -126a-3p displayed a robust decreased expression (> 85%) in the retina. …”

Hypothetical scenario of what is happening at the epithelial lining of the small intestine at the acute phase of <i>V</i>. <i>cholerae</i> infection. by Aziz Bitar (257322)

“…By binding to receptors at the cell surface the bacterium induces increased expression of microRNAs miR-146a and miR-155, thereby decreasing levels of IRAK1 with a consequent decreased inflammatory activity and decreased risk for the bacterium to be eliminated and increasing its chances to thrive at the epithelial lining and even get access to the bodily tissues (B). …”

Cellular glycans analysis by lectin array. by Yanling Yang (427399)

“…<p>(A) Lectin array images of control and KO cell lines. …”

Scatter measures the quality of retinotopy and values decrease in development. by Spencer L. Smith (366143)

Preventive administration of rapamycin permits to decrease severity of EAM. by Nicolas Prevel (483113)

Discovery of an eIF4A Inhibitor with a Novel Mechanism of Action by Christopher J. Zerio (11595690)

“…A medicinal chemistry campaign produced the novel eIF4A inhibitor <b>28</b>, which decreased BJAB Burkitt lymphoma cell viability. …”

Discovery of an eIF4A Inhibitor with a Novel Mechanism of Action by Christopher J. Zerio (11595690)

“…A medicinal chemistry campaign produced the novel eIF4A inhibitor <b>28</b>, which decreased BJAB Burkitt lymphoma cell viability. …”

Discovery of an eIF4A Inhibitor with a Novel Mechanism of Action by Christopher J. Zerio (11595690)

“…A medicinal chemistry campaign produced the novel eIF4A inhibitor <b>28</b>, which decreased BJAB Burkitt lymphoma cell viability. …”

Persistent decrease in dendritic excitability following paired stimulation. by Anna Labno (505791)

“…When no stimulation was applied (top) no change in dendritic excitability is observed, however after paired stimulation (bottom) excitability decreased (<b>D</b>) Dendritic excitability prior to paired stimulation, shows a steady basal level of dendritic excitability as assessed by measuring the peak magnitude of the ChR2-induced photo current. …”

Tom clone number and area decrease during pupariation. by Jeremy Brown (3311742)

Structural Basis for Sequence Specific DNA Binding and Protein Dimerization of HOXA13 by Yonghong Zhang (20918)

“…I366 makes similar methyl contacts with T3* and T4*. Mutants (I366A, N370A and V373G) all have decreased DNA binding and transcriptional activity. …”

Foldases and holdases each decrease the level of unfolded protein. by Adam MR de Graff (9767829)

Phosphosite mutations in Hcm1 decrease fitness in stress. by Michelle M. Conti (13514386)

<i>Cotton Leaf Curl Multan virus</i> C4 protein suppresses both transcriptional and post-transcriptional gene silencing by interacting with SAM synthetase by Asigul Ismayil (5698946)

“…Plants infected with CLCuMuV carrying C4^R13A show decreased levels of symptoms and viral DNA accumulation associated with enhanced viral DNA methylation. …”

The multicopy sRNA LhrC controls expression of the oligopeptide-binding protein OppA in <i>Listeria monocytogenes</i> by Susanne Sievers (256439)

“…For OppA, we show that LhrC acts by direct base paring to the ribosome binding site of the <i>oppA</i> mRNA, leading to an impediment of its translation and a decreased mRNA level. …”

A R13A point mutation in C4 attenuates CLCuMuV infection. by Asigul Ismayil (5698946)

“…<b>(C)</b> The mutant CLCuMuV carrying C4^R13A (CLCuMuV-C4^R13A), which contains a R13A mutation in <i>C4</i>, showed the decreased viral symptom compared to wild type CLCuMuV. …”

Induction of immunomodulatory miR-146a and miR-155 in small intestinal epithelium of <i>Vibrio cholerae</i> infected patients at acute stage of cholera by Aziz Bitar (257322)

“…Only marginal down-regulation of target genes IRAK1 and CARD10 was seen and a weak cytokine-profile was identified in the acute infected mucosa. …”

Decrease of tumor perfusion following anti-angiogenic therapy. by Philipp M. Kazmierczak (465021)

Glucose and statins decrease cholesterol efflux from macrophages. by Wei-Ming Chen (560699)