Table 4_Integrative RNA-seq and CLIP-seq analysis reveals hnRNP-F regulation of TNFα/NFκB signaling in high-glucose conditions.xlsx by Lan Wang (85307)

“…</p>Results<p>In this study, RNA sequencing (RNA-seq) was utilized to demonstrate that the upregulation of hnRNP-F in HK-2 cells cultured under high-glucose conditions resulted in a substantial decrease in the expression of genes associated with the inflammatory response and suppression of the TNFα-NFκB signaling pathway. …”

Table_1_Mare stromal endometrial cells differentially modulate inflammation depending on oestrus cycle status: an in vitro study.docx by Yat S. Wong (17106127)

“…Conversely, in the luteal phase, there is a protective role mediated primarily through an increase in anti-fibrotic miRNAs, a decrease in SMAD2 phosphorylation, and reduced expression of fibrosis-related genes.…”

Image_3_Study of CD27, CD38, HLA-DR and Ki-67 immune profiles for the characterization of active tuberculosis, latent infection and end of treatment.JPEG by Sergio Díaz-Fernández (13136730)

“…Additionally, multiparametric FlowSOM analyses revealed an increase in CD27 cell clusters and a decrease in HLA-DR cell clusters within Mtb-specific populations after the end of treatment.…”

Table_1_Vaccination with an in vitro culture attenuated Babesia bovis strain safely protects highly susceptible adult cattle against acute bovine babesiosis.docx by Reginaldo G. Bastos (6644891)

“…Thus, the use of vaccines based on well-defined in vitro culture attenuated B. bovis strains emerges as a more sustainable and efficient alternative. Previous work demonstrated that the culture attenuated strain Att-S74-T3Bo is non-tick transmissible and able to safely protect calves against needle challenge with a B. bovis virulent strain.…”

Image3_Multi-omics analyses reveal ClpP activators disrupt essential mitochondrial pathways in triple-negative breast cancer.jpg by Emily M. J. Fennell (6654536)

“…GO analysis of these data demonstrated additional similarity of response to ONC201 and TR-57, including a decrease in transcripts related to the mitochondrial inner membrane and matrix, cell cycle, and nucleus, and increases in other nuclear transcripts and transcripts related to metal-ion binding. …”

Table_1_Gegen Qinlian Decoction Coordinately Regulates PPARγ and PPARα to Improve Glucose and Lipid Homeostasis in Diabetic Rats and Insulin Resistance 3T3-L1 Adipocytes.docx by Jun Tu (802496)

“…<p>Gegen Qinlian Decoction (GQD), a well-documented traditional Chinese Medicine (TCM) formula, was reported with convincing anti-diabetic effects in clinical practice. …”

Image1_Neuronal nitric oxide synthase required for erythropoietin modulation of heart function in mice.pdf by Jeeyoung Lee (2638744)

“…</p><p>Results: ΔEPORE mice showed a decrease in the left ventricular outflow tract (LVOT) peak velocity, ejection fraction, and fractional shortening, showing that endogenous non-erythroid EPO response is protective for heart function. …”

The effect of <i>PNPLA4</i> variant on mitochondrial function. by Masakazu Kohda (206767)

“…(<b>C</b>) Immunofluorescence microscopy confirmed the colocalization of PNPLA4 (green) with MitoTracker Orange CMTMRos (red). Pt712 cells showed a decrease in the endogenous PNPLA4 protein level. …”

DataSheet_1_Identifying hub genes in response to ustekinumab and the impact of ustekinumab treatment on fibrosis in Crohn’s disease.zip by Ying Xu (9172)

“…IL18, the ligand of IL18R1, was also found to have lower expression in the blood samples from responders vs. non-responders. (2) GSE112366 revealed a significant decrease in fibrosis-related module genes (COL4A1, TUBB6, IFITM2, SERPING1, DRAM1, NAMPT, MMP1, ZEB2, ICAM1, PFKFB3, and ACTA2) and fibrosis-related pathways (ECM–receptor interaction and PI3K-AKT pathways) after ustekinumab treatment.…”

Image3_Neuronal nitric oxide synthase required for erythropoietin modulation of heart function in mice.pdf by Jeeyoung Lee (2638744)

“…</p><p>Results: ΔEPORE mice showed a decrease in the left ventricular outflow tract (LVOT) peak velocity, ejection fraction, and fractional shortening, showing that endogenous non-erythroid EPO response is protective for heart function. …”

Data_Sheet_1_The role of immune suppression in COVID-19 hospitalization: clinical and epidemiological trends over three years of SARS-CoV-2 epidemic.PDF by Marta Canuti (336637)

“…This change coincided with an increase in the proportions of older patients and patients with co-morbidities and with a decrease in the proportion of patients with severe outcomes. …”

Table1_Neuronal nitric oxide synthase required for erythropoietin modulation of heart function in mice.docx by Jeeyoung Lee (2638744)

“…</p><p>Results: ΔEPORE mice showed a decrease in the left ventricular outflow tract (LVOT) peak velocity, ejection fraction, and fractional shortening, showing that endogenous non-erythroid EPO response is protective for heart function. …”

The heads of <i>FoxO6</i>^<i>-/-</i> mice are larger than those of wild type mice. by Zhao Sun (283073)

“…<p><b>A,B)</b> Alcian Blue/Alizarin Red staining of cartilage and bone skeletal preparations of <i>FoxO6</i>^<i>+/-</i> mice and <i>FoxO6</i>^<i>-/-</i> littermates. …”

Dissociative CO Photosubstitution in M(CO)₄(1,4-diazabutadiene) Complexes (M = W, Mo) by an Olefin Affording Novel <i>f</i><i>ac</i>-M(CO)₃(1,4-diazabutadiene... by Friedrich-Wilhelm Grevels (2671306)

“…Quantum yield measurements at 254, 302, 365, and 405 nm revealed a gradual decrease from Φ ≈ 0.1 to 0.02 and then a sharp drop to 0.001 at 548 nm (CTML excitation). …”

CDA deficiency leads to excess dCTP, inhibiting PARP-1 activity and leading to UFB formation. by Simon Gemble (168663)

“…(G) (1) CDA deficiency leads to intracellular dCTP accumulation, decreasing basal PARP-1 activity. (2) The decrease in basal PARP-1 activity leads to an increase in unreplicated DNA sequences (preferentially at centromeres and CFS sites). (3) During late G2/early mitosis, some of this unreplicated DNA is probably processed by MUS81-EME1 and ERCC1 nucleases as previously suggested [<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1005384#pgen.1005384.ref036" target="_blank">36</a>, <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1005384#pgen.1005384.ref012" target="_blank">12</a>], leading to DNA synthesis during metaphase (EdU foci) and preventing supernumerary UFB formation. (4) Some of the excess unreplicated DNA sequences are not processed by the nucleases, leading to supernumerary UFB formation.…”

The <i>casy-1</i> isoforms functions in GABAergic neurons to regulate synaptic transmission. by Shruti Thapliyal (4951993)

“…Cholinergic synapses are largely normal in <i>casy-1</i> mutants, while GABAergic synapses showed a subtle but significant decrease in fluorescent intensity when compared to WT animals. …”

Table1_Leishmania major surface components and DKK1 signalling via LRP6 promote migration and longevity of neutrophils in the infection site.docx by Olivia C. Ihedioha (19925886)

“…Relative to the WT controls, Δads1^- parasite-infected mice showed a sustained decrease in neutrophils and neutrophil-platelet aggregates (for at least 14 days PI), while neutrophils returned to normal in Δlpg1^- parasite-infected mice after day 3 PI.…”

Antitumor Activity and Induction of TP53-Dependent Apoptosis toward Ovarian Clear Cell Adenocarcinoma by the Dual PI3K/mTOR Inhibitor DS-7423 by Tomoko Kashiyama (162572)

“…In mouse xenograft models, DS-7423 suppressed the tumor growth of OCCA in a dose-dependent manner. Flow cytometry analysis revealed a decrease in S-phase cell populations in all the cell lines and an increase in sub-G1 cell populations following treatment with DS-7423 in six of the nine OCCA cell lines tested. …”

Table_1_Narrowing row spacing and adding inter-block promote the grain filling and flag leaf photosynthetic rate of wheat under enlarged drip tube spacing system.xlsx by Jianguo Jing (18767383)

“…The decline of NS22 (9.93%) was higher than that of NS44 (9.04%), and both cultivars also showed a greater decrease in grain weight and average grain-filling rate (AGFR) of inferior grains (NS22: 23.19%, 13.97%; NS44: 7.78%, 5.86%) than the superior grains (NS22: 10.60%, 8.33%; NS44: 4.89%, 4.62%). …”

Image2_Neuronal nitric oxide synthase required for erythropoietin modulation of heart function in mice.pdf by Jeeyoung Lee (2638744)

“…</p><p>Results: ΔEPORE mice showed a decrease in the left ventricular outflow tract (LVOT) peak velocity, ejection fraction, and fractional shortening, showing that endogenous non-erythroid EPO response is protective for heart function. …”