β-NAD increases intracellular cAMP concentration via soluble adenylyl cyclase, but this pathway is not essential for the relaxing effect. by Innokentij Jurastow (22430601)

“…<p>(A, B) Recording of intracellular cAMP concentration in HBSMC via FRET, with low FRET ratio indicating high cAMP concentration. β-NAD and isoproterenol cause a decrease in FRET ratio, reflecting rise in intracellular cAMP concentration. …”

Image_4_Endocannabinoid signaling regulates post-operative delirium through glutamatergic mediodorsal thalamus-prelimbic prefrontal cortical projection.TIF by Yang Liu (4829)

“…Background<p>Post-operative delirium (POD), a common post-operative complication that affects up to 73. 5% of surgical patients, could prolong hospital stays, triple mortality rates, cause long-term cognitive decline and dementia, and boost medical expenses. …”

Supplementary Material for: Systematic Review and Meta-Analysis of the Impact of Hypoxia on Infarcted Myocardium: Better or Worse? by Pang B. (5404793)

“…Overall, chronic hypoxia was found to have a beneficial effect on the ejection fraction (standard mean difference [SMD] = 5.39; 95% confidence interval [CI], 3.83 to 6.95; <i>P</i> < 0.001) of the infarcted heart, whereas acute hypoxia significantly improved hemodynamics, as indicated by an increase in the maximal rate of rise of left ventricular pressure (SMD = 1.27; 95% CI, 0.27 to 2.28; <i>P</i> = 0.013) and cardiac output (SMD = 1.26; 95% CI, 0.34 to 2.18; <i>P</i> = 0.007) and a decrease in total systematic vascular resistance (SMD = –0.89; 95% CI, –1.24 to –0.53; <i>P</i> < 0.001). …”

Signature of Aberrant DNA Methylation in <i>MYC</i>-Induced T cell Lymphomas by Rene Opavsky (32415)

“…<div><p>(A) Schematic representation of transgenes in <i>MYC</i>-induced T cell lymphoma model used in this study.…”

Significance of the Wnt canonical pathway in radiotoxicity <i>via</i> oxidative stress of electron beam radiation and its molecular control in mice by Shashank Kumar (8916584)

“…Post-irradiation likewise influences the morphology of sperm. The decrease in mRNA levels of Lef1, Axin2, Survivin, Ku70, and XRCC6 levels suggests radiation inhibits the Wnt canonical pathway and failure in DNA repair mechanisms in a coupled manner. …”

Motion of FisB clusters is not coupled to cell wall synthesis, or pH and voltage gradients across the cell membrane. by The PLOS Biology Staff (11836235)

“…Upon treatment with fosfomycin, GFP-Mbl filaments stop moving, which is reflected as a decrease in asymmetry (<i>p</i> = 0.0044), whereas mGFP-FisB’s motion is unaffected (<i>p</i> = 0.8655). …”

Boxplot of the OA group before batch correction. by Chang-sheng Liao (18591969)

“…<div><p>Objective</p><p>To elucidate potential molecular mechanisms differentiating osteoarthritis (OA) and rheumatoid arthritis (RA) through a bioinformatics analysis of differentially expressed genes (DEGs) in patient synovial cells, aiming to provide new insights for clinical treatment strategies.…”

Table1_2-Dimensional in vitro culture assessment of ovarian cancer cell line using cost effective silver nanoparticles from Macrotyloma uniflorum seed extracts.DOCX by Kousalya Lavudi (11838779)

“…Propidium iodide-based Cell cycle study has shown a significant decrease in G0/G1 phase compared to control (88.8%), which further confirmed the apoptotic induction. …”

Related to Fig 3. Neither <i>Catalase</i> nor <i>Sod1</i> overexpression restore cytoskeletal loops to <i>NDUFS7</i>-deficient animals. by Bhagaban Mallik (12459375)

“…The motor neuron-depleted <i>NDUFS7[RNAi]</i> larvae showed a decrease in the number of Futsch-positive loops as compared to the Gal4 control. …”

DataSheet_1_Canagliflozin alters the gut, oral, and ocular surface microbiota of patients with type 2 diabetes mellitus.xls by Limin Wang (87511)

“…</p>Clinical parameters<p>A significant decrease in fasting plasma glucose (8.22 ± 2.19 vs 6.87 ± 1.09 mmol/L), glycated serum protein [291.00 (264.00, 353.00) vs 275.00 (251.00, 342.50) μmol/L], hemoglobin A1c (7.39 ± 1.18 vs 7.12 ± 1.33%), body mass index (25.32 ± 2.99 vs 24.83 ± 2.95 kg/m²), systolic blood pressure (129.05 ± 17.51 vs 123.43 ± 14.82 mmHg), and urinary creatinine [158.40 (74.75, 219.15) vs 79.70 (56.25, 138.10) μmmol/kg] levels was noted after 30-day Cana monotherapy (P < 0.05).…”

Boxplot of the RA group after batch correction. by Chang-sheng Liao (18591969)

“…<div><p>Objective</p><p>To elucidate potential molecular mechanisms differentiating osteoarthritis (OA) and rheumatoid arthritis (RA) through a bioinformatics analysis of differentially expressed genes (DEGs) in patient synovial cells, aiming to provide new insights for clinical treatment strategies.…”

4-methylthiobutyl isothiocyanate synergize the antiproliferative and pro-apoptotic effects of paclitaxel in human breast cancer cells by Harneetpal Kaur (13973217)

“…In western blot experiment, the combination had a significant decrease in Bcl-xl protein level, whereas a higher level of p53, cleaved caspase-3, and cleaved caspase-9 proteins compared to individual treatment in <i>T</i>-47D cells. …”

Table_1_Neutrophil Extracellular Traps in SARS-CoV2 Related Pneumonia in ICU Patients: The NETCOV2 Study.DOCX by Mathieu Godement (10180910)

“…<p>Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a poorly understood disease involving a high inflammatory status. …”

DataSheet_3_Canagliflozin alters the gut, oral, and ocular surface microbiota of patients with type 2 diabetes mellitus.xls by Limin Wang (87511)

“…</p>Clinical parameters<p>A significant decrease in fasting plasma glucose (8.22 ± 2.19 vs 6.87 ± 1.09 mmol/L), glycated serum protein [291.00 (264.00, 353.00) vs 275.00 (251.00, 342.50) μmol/L], hemoglobin A1c (7.39 ± 1.18 vs 7.12 ± 1.33%), body mass index (25.32 ± 2.99 vs 24.83 ± 2.95 kg/m²), systolic blood pressure (129.05 ± 17.51 vs 123.43 ± 14.82 mmHg), and urinary creatinine [158.40 (74.75, 219.15) vs 79.70 (56.25, 138.10) μmmol/kg] levels was noted after 30-day Cana monotherapy (P < 0.05).…”

Temporal trends in Human T-Lymphotropic virus 1 (HTLV-1) associated myelopathy/tropical spastic paraparesis (HAM/TSP) incidence in Martinique over 25 years (1986-2010) by Stephane Olindo (4976189)

“…Between 1996–2000 and 2011–2015 study periods, the HTLV-1 seroprevalence significantly decreased by 63%.</p><p>Conclusion</p><p>Martinique faces a sudden and rapid decline of HAM/TSP incidence from 2001 in comparison to 1986–2000 periods. …”

Data_Sheet_1_Fully Integrated PET/MR Imaging for the Assessment of the Relationship Between Functional Connectivity and Glucose Metabolic Rate.PDF by Lalith Kumar Shiyam Sundar (8622243)

“…Discussion: Measurement of functional connectivity within established brain networks did not provide a means to decrease the inter- or intrasubject variability of CMRGlc values. …”

Image_3_Endocannabinoid signaling regulates post-operative delirium through glutamatergic mediodorsal thalamus-prelimbic prefrontal cortical projection.TIF by Yang Liu (4829)

“…Background<p>Post-operative delirium (POD), a common post-operative complication that affects up to 73. 5% of surgical patients, could prolong hospital stays, triple mortality rates, cause long-term cognitive decline and dementia, and boost medical expenses. …”

The role of TCTP and CSN4 in the control of CULLIN neddylation and cell proliferation is conserved in <i>Drosophila</i>. by Léo Betsch (6273707)

“…<b>(g)</b> Impaired larval development is associated with a decrease of the CUL1^NEDD8 abundance in the <i>tub</i>><i>dTCTPi</i> compared to <i>tub</i>-GAL4. …”

Genetic screen in haploid ESCs for PMP resistance identifies Anoikis modulators. by Giulio Di Minin (4768200)

“…<p><b>(A)</b> Model of the activity of known SMO targeting compounds. …”

The Effect of Probiotic Treatment on Patients Infected with the H7N9 Influenza Virus by Xinjun Hu (412383)

“…<div><p>Background</p><p>A novel avian-origin influenza A (H7N9) virus emerged and spread among humans in Eastern China in 2013. …”