Impact of time to treatment initiation for patients with oral cavity squamous cell carcinoma: a population-based, retrospective study by Jakob Schmidt Jensen (4528264)

“…Univariate analyses showed a statistically significant increase in hazard ratio for both OS and RFS with a five-day increase in TTI (HR = 1.05, 95%CI: 1.02–1.07 and HR = 1.04, 95%CI: 1.02–1.07). …”

Data Sheet 1_Patient engagement in radiation oncology: a large retrospective study of survey response dynamics.docx by Bailey A. Loving (20573882)

“…</p>Methods<p>This retrospective study analyzed data from radiation oncology patients at a large multi-site single-institution center from May 2021 to January 2024. …”

Table_1_A synonymous mutation in PI4KA impacts the transcription and translation process of gene expression.docx by Kaihui Zhang (2162758)

“…<p>Phosphatidylinositol-4-kinase alpha (PI4KIIIα), encoded by the PI4KA gene, can synthesize phosphatidylinositol-4-phosphate (PI-4-P), which serves as a specific membrane marker and is instrumental in signal transduction. …”

Data_Sheet_1_Causal Association Between Tea Consumption and Bone Health: A Mendelian Randomization Study.docx by Song Chen (69646)

“…To determine the causal relationship between genetically predicted tea intake and OA, RA, and OP, we performed a two-sample Mendelian randomization (MR) study based on large samples.…”

Table_8_Effects of Flavonoid Supplementation on Nanomaterial-Induced Toxicity: A Meta-Analysis of Preclinical Animal Studies.DOCX by Dongli Xie (400786)

“…STATA 15.0 software was used for meta-analyses.</p>Results<p>A total of 26 studies were identified. The results showed that flavonoid supplementation could significantly increase the levels of antioxidative enzymes (superoxide dismutase, catalase, glutathione, glutathione peroxidase, and glutathione-S-transferase), reduce the production of oxidative agents (malonaldehyde) and pro-inflammatory mediators (tumor necrosis factor-α, interleukin-6, IL-1β, C-reactive protein, immunoglobulin G, nitric oxide, vascular endothelial growth factor, and myeloperoxidase), and alleviate cell apoptosis (manifested by decreases in the mRNA expression levels of pro-apoptotic factors, such as caspase-3, Fas cell surface death receptor, and Bax, and increases in the mRNA expression levels of Bcl2), DNA damage (reductions in tail length and tail DNA%), and nanomaterial-induced injuries of the liver (reduced alanine aminotransferase and aspartate aminotransferase activities), kidney (reduced urea, blood urea nitrogen, creatinine, and uric acid concentration), testis (increased testosterone, sperm motility, 17β-hydroxysteroid dehydrogenase type, and reduced sperm abnormalities), and brain (enhanced acetylcholinesterase activities). …”

Video1_Journey through a virtual tunnel: Simulated motion and its effects on the experience of time.MP4 by Maximilian Landeck (11151309)

“…Previous work has shown that the perception of motion can affect the perception of time. We developed a virtual environment that simulates motion in a tunnel and measured its effects on the estimation of the duration of time, the speed at which perceived time passes, and the illusion of self-motion, also known as vection. …”

Image_1_Lutzomyia longipalpis TGF-β Has a Role in Leishmania infantum chagasi Survival in the Vector.TIF by Tatiana Di-Blasi (4680811)

“…The blockage of the LlTGF-β pathway increased significantly antimicrobial peptides expression and nitric oxide levels in the insect gut, as expected. Both methods led to a decreased L. i. chagasi infection. Our results show that inactivation of the L. longipalpis TGF-β signal transduction pathway reduce L. i. chagasi survival, therefore suggesting that under natural conditions the parasite benefits from the insect LlTGF-β pathway, as already seen in Plamodium infection of mosquitoes.…”

Table_9_Effects of Flavonoid Supplementation on Nanomaterial-Induced Toxicity: A Meta-Analysis of Preclinical Animal Studies.DOCX by Dongli Xie (400786)

“…STATA 15.0 software was used for meta-analyses.</p>Results<p>A total of 26 studies were identified. The results showed that flavonoid supplementation could significantly increase the levels of antioxidative enzymes (superoxide dismutase, catalase, glutathione, glutathione peroxidase, and glutathione-S-transferase), reduce the production of oxidative agents (malonaldehyde) and pro-inflammatory mediators (tumor necrosis factor-α, interleukin-6, IL-1β, C-reactive protein, immunoglobulin G, nitric oxide, vascular endothelial growth factor, and myeloperoxidase), and alleviate cell apoptosis (manifested by decreases in the mRNA expression levels of pro-apoptotic factors, such as caspase-3, Fas cell surface death receptor, and Bax, and increases in the mRNA expression levels of Bcl2), DNA damage (reductions in tail length and tail DNA%), and nanomaterial-induced injuries of the liver (reduced alanine aminotransferase and aspartate aminotransferase activities), kidney (reduced urea, blood urea nitrogen, creatinine, and uric acid concentration), testis (increased testosterone, sperm motility, 17β-hydroxysteroid dehydrogenase type, and reduced sperm abnormalities), and brain (enhanced acetylcholinesterase activities). …”

Image_1_Microbiological profile of diabetic foot infections in China and worldwide: a 20-year systematic review.pdf by Yu-dun Qu (17869511)

“…We aimed to determine the incidence and antibiotic susceptibility of DFI pathogens worldwide, focusing on Asia and China.</p>Methods<p>Through a comprehensive literature search, we identified published studies on organisms isolated from DFI wounds from January 2000 to December 2020.…”

Table 2_Association of cardiorespiratory fitness with phenotypic age in younger population: a study based on the NHANES database.docx by Yi Shen (152956)

“…</p>Results<p>In the multivariable logistical regression analysis, maintenance of CRF was significantly and inversely associated with PAA, demonstrating a decreased risk of 42% in the high CRF group [OR (95% CI): 0.58 (0.36, 0.96), p = 0.033]. …”

Table 1_Urinary and oral microbiota in Polish women: a pilot case-control study of breast cancer.docx by Anna Marciniak (12354534)

“…Introduction<p>The human microbiota can be a critical component in the development and progression of various diseases, including cancer. …”

Table_2_Biogenic Silver Nanoparticles as a Post-surgical Treatment for Corynebacterium pseudotuberculosis Infection in Small Ruminants.docx by Laerte Marlon Santos (6628370)

“…It can be concluded that post-surgical treatment of CL using the AgNP-based ointment may be a promising tool in the control of CL, through faster healing, decreased wound contamination, and no apparent toxic effects.…”

Image_1_A population of dermal Langerin+ dendritic cells promote the inflammation in mouse model of atopic dermatitis.tif by Chunying Xiao (8612091)

DataSheet1_Lithium-induced apoptotic cell death is not accompanied by a noticeable inflammatory response in the kidney.docx by Irina Baranovskaya (8166219)

“…The TUNEL-positive signal and levels of pro-apoptotic proteins, Bax, cleaved caspase-3, and caspase-8, were elevated in the kidneys of Li⁺-treated mice. We observed a significantly higher abundance of CD93, CCL21, and fractalkine, accumulation of F4.80⁺ macrophages with reduced M1/M2 polarization ratio and decreased CD4⁺ levels in the renal tissue of Li⁺-treated mice when compared to controls. …”

Image_3_Use of Clinical Isolates to Establish Criteria for a Mouse Model of Latent Cryptococcus neoformans Infection.jpeg by Minna Ding (12031985)

“…In this study, we defined criteria required for latency in C. neoformans infection models and used these criteria to develop a murine model of persistent C. neoformans infection using clinical isolates. …”

Audio_1_Influence of Auditory Cues on the Neuronal Response to Naturalistic Visual Stimuli in a Virtual Reality Setting.WAV by George Al Boustani (12717983)

“…To investigate the effect of additional auditory cues on the processing of visual information, we used virtual reality to mimic safety-related events in an industrial environment while we concomitantly recorded electroencephalography (EEG) signals. We simulated a box traveling on a conveyor belt system where two types of stimuli – an exploding and a burning box – interrupt regular operation. …”

Image_3_Lutzomyia longipalpis TGF-β Has a Role in Leishmania infantum chagasi Survival in the Vector.JPEG by Tatiana Di-Blasi (4680811)

“…The blockage of the LlTGF-β pathway increased significantly antimicrobial peptides expression and nitric oxide levels in the insect gut, as expected. Both methods led to a decreased L. i. chagasi infection. Our results show that inactivation of the L. longipalpis TGF-β signal transduction pathway reduce L. i. chagasi survival, therefore suggesting that under natural conditions the parasite benefits from the insect LlTGF-β pathway, as already seen in Plamodium infection of mosquitoes.…”

Table_2_Causal associations between gut microbiota and Cholestatic liver diseases: a Mendelian randomization study.XLSX by Jiaqi Yang (4380466)

“…</p>Result<p>This two-sample MR study indicated that the order Bacillales, family Peptostreptococcaceae, family Ruminococcaceae, genus Anaerotruncu was associated with a decreased risk of developing PBC, and that order Selenomonadales, family Bifidobacteriaceae may be factors that increase the risk of PBC. …”

Data from: Making a queen: an epigenetic analysis of the robustness of the honey bee (Apis mellifera) queen developmental pathway by Xu Jiang He (8029184)

“…Specialized castes are considered a key reason for the evolutionary and ecological success of the social insect lifestyle. …”

Appendicular skeletal muscle mass: A more sensitive biomarker of disease severity than BMI in adults with mitochondrial diseases by Yue Hou (2562085)

“…Altogether, compared with BMI, ASMI is a more sensitive biomarker predicting disease severity of MD, both in MELAS and CPEO patients.…”