A Potent Isoprenylcysteine Carboxylmethyltransferase (ICMT) Inhibitor Improves Survival in Ras-Driven Acute Myeloid Leukemia by Nagore I. Marín-Ramos (1600555)

“…Compound <b>3</b> significantly impairs the membrane association of the four Ras isoforms, leading to a decrease of Ras activity and to inhibition of Ras downstream signaling pathways. …”

Restricting the ψ Torsion Angle Has Stereoelectronic Consequences on a Scissile Bond: An Electronic Structure Analysis by Eric R. Strieter (1319670)

“…Electronic distortion is manifested by a decrease in the strength of the donor–acceptor interaction between the amide nitrogen and antibonding orbital (π*) of the carbonyl. …”

DataSheet_1_Induction of diabetes by Tacrolimus in a phenotypic model of obesity and metabolic syndrome.docx by Silvia Teixidó-Trujillo (18458343)

“…There were also changes in beta-cell nuclear factors such as a decrease in nuclear expression of MafA and a nuclear overexpression of FoxO1A, PDX-1 and NeuroD1. …”

Effect of Aerobic Training on Heart Rate Recovery in Patients with Established Heart Disease; a Systematic Review by Johan A. Snoek (499076)

“…<div><p>Background</p><p>Although a delayed decrease in heart rate during the first minute after graded exercise has been identified as a powerful predictor of overall mortality in cardiac patients, the potential to influence this risk factor by aerobic training remains to be proven.…”

Withanolide A mediated transcriptional regulation of Nrf2 and GCLC expression depend on corticosterone signaling in hippocampus. by Iswar Baitharu (414359)

“…Administration of Withanolide A alongwith exogenous corticosterone supplementation to the normoxic group decrease the Nrf2 as well as GCLC expression while inhibition of corticosterone synthesis using metyrapone during hypoxia reverses hypoxia induced downregulation of both Nrf2 and GCLC level. β-actin was used as a loading control. …”

Table4_LeishIF3d is a non-canonical cap-binding protein in Leishmania.XLSX by Priyanka Bose (7110071)

“…<p>Translation of most cellular mRNAs in eukaryotes proceeds through a cap-dependent pathway, whereby the cap-binding complex, eIF4F, anchors the pre-initiation complex at the 5′ end of mRNAs driving translation initiation. …”

Supplementary Material for: Inadvertent intoxication with salbutamol, treated with hemodialysis: a case report and brief review of the literature by Bezeljak N. (17302459)

“…Introduction Salbutamol is a moderately selective beta-2-adrenergic agonist. …”

Table_1_Predictors of Burnout Among Physicians: Evidence From a National Study in Portugal.DOCX by Alexandra Marques-Pinto (11057451)

“…Results show that 66% of physicians have high levels of emotional exhaustion, 33% high levels of depersonalization, and 39% high levels of decrease of personal accomplishment. Moreover, a first set of hierarchical multiple regression models with burnout symptoms reveals that organizational resources, demands of the relationship with the patients and of work schedule are consistently important predictors of emotional exhaustion and depersonalization on top of other theoretically relevant predictors. …”

Automated Calibration of a Poly(oxymethylene) Dimethyl Ether Oxidation Mechanism Using the Knowledge Graph Technology by Jiaru Bai (10534865)

“…We find that calibration times are reduced, while accuracy is increased compared to manual calibration, achieving a 79% decrease in the objective function value, as defined in this study. …”

A Mononuclear Non-Heme Manganese(IV)–Oxo Complex Binding Redox-Inactive Metal Ions by Junying Chen (286746)

“…The reactivities of the Mn­(IV)–oxo complex are markedly influenced by binding of Sc³⁺ ions in oxidation reactions, such as a ∼2200-fold increase in the rate of oxidation of thioanisole (i.e., oxygen atom transfer) but a ∼180-fold decrease in the rate of C–H bond activation of 1,4-cyclohexadiene (i.e., hydrogen atom transfer). …”

Drug-induced inhibition of HMGA and EZH2 activity as a possible therapy for anaplastic thyroid carcinoma by Marco De Martino (3813844)

“…Then, treatment of the ATC cell lines with trabectedin and GSK126 resulted in a drastic induction of apoptotic cell death, which increased when the ATC cell lines were treated with a combination of both drugs. …”

A Functional Screen Identifies Specific MicroRNAs Capable of Inhibiting Human Melanoma Cell Viability by Jos B. Poell (140417)

“…Several miRNAs have already been shown to attenuate cancer phenotypes, by limiting proliferation, invasiveness, tumor angiogenesis, and stemness. Here, we employed a genome-scale lentiviral human miRNA expression library to systematically survey which miRNAs are able to decrease A375 melanoma cell viability. …”

Image8_LeishIF3d is a non-canonical cap-binding protein in Leishmania.TIF by Priyanka Bose (7110071)

“…<p>Translation of most cellular mRNAs in eukaryotes proceeds through a cap-dependent pathway, whereby the cap-binding complex, eIF4F, anchors the pre-initiation complex at the 5′ end of mRNAs driving translation initiation. …”

Transcriptional control in embryonic Drosophila midline guidance assessed through a whole genome approach-3 by Tiago R Magalhães (76330)

“…A distinct region follows, in which there is a significant decrease in the mutants robo, robo2, slit.robo and the transgenic UC2x. (1b) Medoids for the developmental time course. …”

R-loops accumulate in p.A382T TDP-43 mutated LCLs. Related to Fig 6. by Marta Giannini (5534324)

“…<p><b>A)</b> IF of LCL-CTL, LCL-TDP382, LCL-SALS using an anti-TDP-43 antibody and an anti-S9.6 antibody after paraformaldehyde fixation. …”

Can omega-3 fatty acids be beneficial in pediatric NAFLD? A systematic review and meta-analysis by Georgios Dionysopoulos (17313826)

“…In addition, a significant improvement in liver steatosis assessed by ultrasonography and a decrease in BMI were observed. …”

Image_3_Influence of the Calcium Carbonate Shell of Coccolithophores on Ingestion and Growth of a Dinoflagellate Predator.tiff by Mathias Haunost (2951679)

“…Calcified and decalcified cells of the coccolithophore species Emiliania huxleyi, Pleurochrysis carterae, and Gephyrocapsa oceanica were offered separately to the predator as well as in an initial ∼1:1 mixture. The decrease of the prey concentrations and predator abundances were monitored over a period of 48–72 h. …”

The Effects of Low-Dose Ketamine on Acute Pain in an Emergency Setting: A Systematic Review and Meta-Analysis by Eun Nam Lee (3279510)

“…Data were also extracted independently.</p><p>Results</p><p>A total of 6 trials involving 438 patients were included in the current analysis. …”

Image_2_Synbiotics Containing Nanoprebiotics: A Novel Therapeutic Strategy to Restore Gut Dysbiosis.TIF by Liang Hong (336276)

“…<p>A new formulation, nanoprebiotics [e.g., phthalyl pullulan nanoparticles (PPNs)], was demonstrated to enhance the antimicrobial activity of probiotics [e.g., Lactobacillus plantarum (LP)] in vitro through intracellular stimulation better than that by backbone prebiotics, which are commonly used. …”

Responses of Plant Community Composition and Biomass Production to Warming and Nitrogen Deposition in a Temperate Meadow Ecosystem by Tao Zhang (43681)

“…However, its effects on plant community composition and biomass production are not well understood. A four-year field experiment was conducted to examine the effects of warming, nitrogen (N) addition, and their interactions on plant community composition and biomass production in a temperate meadow ecosystem in northeast China. …”