Specific down regulation of endogenous gene in <i>P. falciparum</i> using PNA molecules. by Netanel Kolevzon (512721)

“…NF54-<i>luc</i> parasites constitutively expressing the <i>luciferase</i> reporter gene were incubated with 1.2, 2.4, 4.8 and 9.6 µM of either Sec13-PNA or Scr-Sec13-PNA. 72h post incubation the parasitemia was counted by direct microscopy (left panel) as well as inhibition of <i>luciferase</i> expression (right panel). The parasitemia decreased in a dose dependent manner only in parasite treated with Sec13-PNA. …”

Image_1_Genomic and Proteomic Analyses of Salmonella enterica Serovar Enteritidis Identifying Mechanisms of Induced de novo Tolerance to Ceftiofur.JPEG by Devon Radford (5732165)

“…<p>With the alarming proliferation of antibiotic resistance, it is important to understand the de novo development of bacterial adaptation to antibiotics in formerly susceptible lineages, in the absence of external genetic input from existing resistance pools. A strain of ceftiofur susceptible Salmonella enterica serovar Enteritidis ABB07-SB3071 (MIC = 1.0 μg/ml) was successively exposed to sub-MIC of ceftiofur to allow its adaptation for tolerance to a concentration of 2.0 μg/ml of this antibiotic. …”

DataSheet1_The platinum coordination complex inhibits cell invasion-migration and epithelial-to-mesenchymal transition by altering the TGF-β-SMAD pathway in colorectal cancer.docx by Maha-Hamadien Abdulla (67713)

“…<p>Introduction: There is a steady increase in colorectal cancer (CRC) incidences worldwide; at diagnosis, about 20 percent of cases show metastases. …”

Data_Sheet_2_Differential effects on TDP-43, piezo-2, tight-junction proteins in various brain regions following repetitive low-intensity blast overpressure.CSV by Lanier Heyburn (7055039)

“…</p>Methods<p>In this study, using a rodent model of relBOP and western blotting for protein expression we showed the differential expression of various neuropathological proteins like TDP-43, tight junction proteins (claudin-5, occludin, and glial fibrillary acidic protein (GFAP)) and a mechanosensitive protein (piezo-2) in different regions of the brain at different intensities and frequency of blast.…”

Image 3_Therapeutic plasma exchange accelerates immune cell recovery in severe COVID-19.jpeg by Aurelie Guironnet-Paquet (15407171)

“…</p>Methods<p>In this study, we set up a prospective, randomised clinical trial (ClinicalTrials.gov ID: NCT04751643) and performed therapeutic plasma exchange (TPE) in severe COVID-19 patients in order to decrease excess cytokines and auto-antibodies and to assess whether adding TPE to the standard treatment (ST, including corticosteroids plus high-flow rate oxygen) could help restore immune parameters and limit the progression of acute respiratory distress syndrome (ARDS).…”

SufT is essential for <i>in vitro</i> growth and regulates survival under redox stress and inside macrophages. by Ashutosh Tripathi (2827796)

“…<p>(A) A gradual decrease in the growth of the SufT-KD strain with increasing concentration of ATc (0–200 ng/mL) in standard liquid 7H9 medium. …”

MK-2206 induced cytotoxicity, inhibited proliferation and was able to overcome the protective effects of the tumor microenvironment. by Vijay Ramakrishnan (117159)

“…<p>When we cultured MM cell lines with indicated concentrations of MK-2206 for 48 hrs we observed dose dependent decrease in <b>A)</b> viability as observed by MTT assays and <b>B)</b> tritiated thymidine uptake indicative of inhibition of proliferation albeit with differences in the sensitivity of cell lines to MK-2206. …”

The Complete Guide to EB-2 National Interest Waiver: Comprehensive Analysis of Matter of Dhanasar for International Professionals by Wederson Marinho (21029060)

“…<p dir="ltr">This white paper presents a comprehensive analysis of the EB-2 National Interest Waiver (NIW) under the Matter of Dhanasar precedent (AAO 2016). …”

Image1_Sedimentary Anthropogenic Carbon Signals From the Western Pacific Margin for the Last Century.pdf by Jay Lee (2373886)

“…To investigate the anthropogenic carbon signal in the Western Pacific, foraminiferal records in a suite of 13 box cores with good age control were obtained from the continental slope off southwestern Taiwan between 2004 and 2006. δ¹⁸O values of planktonic foraminifera (Globigerinoides sacculifer or so-called Trilobatus sacculifer) in collected cores were relatively stable at −2.5‰ to −2‰ in the last century, but foraminiferal δ¹³C had a gradual secular decline after the 1900s. …”

Data_Sheet_1_Does Stream Water Composition at Sleepers River in Vermont Reflect Dynamic Changes in Soils During Recovery From Acidification?.docx by Jesse R. Armfield (6424550)

“…Although base cations, especially Ca, decrease progressively with time in GW, riparian soils have become more enriched in Ca, due to a mixture of lateral and vertical transfers. …”

Annual measurements of vegetation cover on line-point intercept transects from the three Conmod Pilot study locations at Jornada Basin LTER, 2008-2016 by Debra Peters (17483247)

“…</p> <p>File Name: Web Page, url: <a href="https://portal.edirepository.org/nis/mapbrowse?…”

Data_Sheet_1_Proviral Quasispecies Diversity Is Not Associated With Virologic Breakthrough or CD4+ T Cell Loss in HIV-1 Elite Controllers.PDF by Suwellen S. D. de Azevedo (5369807)

“…The aim of this study was to assess the importance of proviral diversity as a prognostic marker of virologic and/or immunologic progression in EC. …”

Data Sheet 1_Characterization of vaginal microbiota across female reproductive phases.zip by Qingzhi Zhai (21265412)

“…Background<p>The vaginal microbiota plays a crucial role in women’s reproductive health, but its composition and function throughout different female reproductive phases remain poorly understood. …”

IGF2 expression is rapamycin-insensitive in <i>Tsc2</i>^<i>-/-</i> MEFs and human LAM cells. by Blanca E. Himes (153105)

“…<p><i>Tsc2</i>^<i>-/-</i> and <i>Tsc2</i>^<i>+/+</i> MEFs were grown to near confluence, serum deprived for 2 hr and treated with indicated concentrations of rapamycin for 24 hr, followed by western blot analysis with indicated antibodies. (A) Treatment with 10nM rapamycin for 24 hr did not decrease Igf2 protein expression, although this dose completely suppressed pS6. …”

Table_1_Endocannabinoids Produced by White Adipose Tissue Modulate Lipolysis in Lean but Not in Obese Rodent and Human.docx by Chloé Buch (9093966)

“…In the present study, we used different strategies to acutely increase ECS activity in WAT and tested the consequences on glycerol production as a marker of lipolysis. Treating lean mice or rat WAT explants with JLZ195, which inhibits ECs degrading enzymes, induced an increase in 2-AG tissue contents that was associated with a CB1R-dependent decrease in lipolysis. …”

Hepatic injury and CA II expression and activity after cold ischemia. by Mohamed Bejaoui (777308)

“…<p>(A) Hepatic injury after cold ischemia in IGL-1 solution supplemented or not with CA II, measured as AST and ALT levels. …”

Table_3_miR-344-5p Modulates Cholesterol-Induced β-Cell Apoptosis and Dysfunction Through Regulating Caveolin-1 Expression.docx by Xulong Sun (11195769)

“…<p>Diabetes is a metabolic disorder induced by the modulation of insulin on glucose metabolism, and the dysfunction and decreased number of islets β-cells are the main causes of T2DM (type 2 diabetes mellitus). …”

Image 1_Effects of Long-term low-dose intermittent rapamycin administration on glucose metabolism and immune system of SAMP8 and SAMR1 mice.tiff by Luiz Adriano Damasceno Queiroz (18116671)

“…In SAMR1 mice, RAPA administration led to a decrease in CD3⁺ thymocytes and splenic lymphoproliferative capacity, while also enhanced mitochondrial performance. …”

DataSheet2_Fungal Inhibition of Agricultural Soil Pathogen Stimulated by Nitrogen-Reducing Fertilization.xlsx by Min-Chong Shen (11931986)

“…These findings provide a theoretical basis for a nitrogen-reducing fertilization strategy against tobacco diseases without exogenous additives and make contributions to revealing the microbial mechanism of native-valued fungal key taxa against tobacco diseases, which could be stimulated by agricultural fertilization management.…”

Mechanisms Involved in the Functional Divergence of Duplicated GroEL Chaperonins in <em>Myxococcus xanthus</em> DK1622 by Yan Wang (15435)

“…In this study, we show that, from the expression levels of different <i>groELs</i>, the distinct functions of <i>groEL1</i> and <i>groEL2</i> in predation and development are probably the result of the substrate selectivity of the paralogous GroEL chaperonins, whereas the lethal effect of heat shock due to the deletion of <i>groEL1</i> is caused by a decrease in the total <i>groEL</i> expression level. …”