DataSheet1_Identification of biomarkers and potential drug targets in osteoarthritis based on bioinformatics analysis and mendelian randomization.docx by Feng Cheng (124653)

“…Further refinement identified two core genes (ARL4C and GAPDH), whose expression levels were found to decrease in OA pathology and exhibited a protective effect in the MR analysis, thus demonstrating consistent trends. …”

The probability of detection (POD) of the sign of change in the CMIP5 climate model simulations from the period 1951–1977 to the period 1978–2004 for the four combinations of warm/... by Zengchao Hao (557031)

“…The number of occurrences of these four combinations during the second half of the 20th century (1951–2004) is assessed on a common global grid. CRU and UD observations show substantial increases in the occurrence of joint warm/dry and warm/wet combinations for the period 1978–2004 relative to 1951–1977. …”

Data_Sheet_2_Excess nitrogen responsive HvMADS27 transcription factor controls barley root architecture by regulating abscisic acid level.docx by Aleksandra Smoczynska (13774630)

“…Additionally, there was a significant decrease in HvMADS27 expression under excess N condition; however, its expression was not significantly affected under low N condition. …”

Significance of miR-196b in Tumor-Related Epilepsy of Patients with Gliomas by Gan You (133029)

“…<div><h3>Objectives</h3><p>Seizure is a common presenting symptom of primary brain tumors. …”

Insulin Signaling in Liver and Adipose Tissues in Periparturient Dairy Cows Supplemented with Dietary Nicotinic Acid by Asako Kinoshita (511938)

“…Cows in HC had significantly higher dietary energy intake than cows in LC. In RPAT a decrease in PI3K and PKCζ expression was found in all groups, irrespectively of diet. …”

Novel derivative of Paeonol, Paeononlsilatie sodium, alleviates behavioral damage and hippocampal dendritic injury in Alzheimer's disease concurrent with cofilin1/phosphorylated-co... by Fei Han (24308)

“…</b> (<b>A</b>) CA1 pyramidal neurons and their traces drawn by ImageJ software. …”

Table1_BMI1 fine-tunes gene repression and activation to safeguard undifferentiated spermatogonia fate.XLSX by Ruiqi Liu (3873832)

“…B cell-specific Moloney murine leukemia virus integration site 1 (BMI1), one of spermatogonial stem cell markers, is a member of Polycomb repressive complex 1 (PRC1) and important to spermatogenesis. …”

Table_1_The association between genetic variants at 3’-UTR and 5’-URR of HLA-G gene and the clinical outcomes of patients with leukemia receiving hematopoietic stem cell transplant... by Ding-Ping Chen (164867)

“…Our results revealed that two SNPs (rs371194629 and rs9380142) and one haplotype (UTR-3) located in the 3’-UTR and two SNPs (rs3823321 and rs1736934) and one haplotype (G0104a) located in the 5’-URR of HLA-G were associated with the occurrence of chronic GVHD or development of any forms of GVHD. …”

DataSheet_1_Green tea extract suppresses airway inflammation via oxidative stress-driven MAPKs/MMP-9 signaling in asthmatic mice and human airway epithelial cells.zip by Jeong-Won Kim (18464976)

“…</p>Results<p>The GTE100 and GTE400 groups showed a decrease in airway hyperresponsiveness and the number of inflammatory cells in the bronchoalveolar lavage fluid (BALF) compared to the OVA group. …”

Secreted Protein Acidic and Rich in Cysteine Mediated Biomimetic Delivery of Methotrexate by Albumin-Based Nanomedicines for Rheumatoid Arthritis Therapy by Lu Liu (171341)

“…By unraveling the mechanism driving the efficient accumulation of MTX@HSA NMs in RA joints and showing their ability to improve the safety and therapeutic efficacy of MTX, our work sheds light on the development of innovative anti-RA nanomedicines with a strong potential for clinical translation.…”

Table_1_Higher radiation dose on immune cells is associated with radiation-induced lymphopenia and worse prognosis in patients with locally advanced esophageal squamous cell carcin... by Jianjian Qiu (12109382)

“…Moreover, high-EDIC was associated with a higher incidence of grade 4 RIL (OR = 2.053, P = 0.007) than low-EDIC. …”

Data_Sheet_1_Manual acupuncture benignly regulates blood-brain barrier disruption and reduces lipopolysaccharide loading and systemic inflammation, possibly by adjusting the gut mi... by Yue Zhang (30585)

“…These effects were comparable to probiotics. The decrease in LPS load and systemic inflammation may play important roles in the regulation of BBB dysfunction by acupuncture, and the gut microbiota may be a potential target for the benign regulation of BBB disruption by acupuncture.…”

Table_1_The reduced SCFA-producing gut microbes are involved in the inflammatory activation in Kawasaki disease.docx by Fangyan Wang (6410591)

“…In vitro, butyrate, not acetate or propionate, increased the expression of phosphatase MKP-1 to dephosphorylate activated JNK, ERK1/2 and p38 MAPK against excessive inflammation in RAW264.7 macrophages. It suggests a new insight into probiotics and their metabolites supplements to treat KD.…”

Data_Sheet_1_Low-Intensity Focused Ultrasound Stimulation Ameliorates Working Memory Dysfunctions in Vascular Dementia Rats via Improving Neuronal Environment.ZIP by Faqi Wang (2072857)

“…This study adds to the evidence that LIFUS could become a promising and non-invasive treatment strategy for the clinical treatment of central nervous system diseases related to cognitive impairments in the future.…”

Image_1_Subjective Vividness of Kinesthetic Motor Imagery Is Associated With the Similarity in Magnitude of Sensorimotor Event-Related Desynchronization Between Motor Execution and... by Hisato Toriyama (5572409)

“…These findings suggest that in healthy individuals with higher motor imagery ability from a first-person perspective, KMI efficiently engages the shared cortical circuits corresponding with motor execution, including the sensorimotor cortex, with high compliance.…”

Seasonality Affects Macroalgal Community Response to Increases in <i>p</i>CO₂ by Cecilia Baggini (625249)

“…This differs from the typical macroalgal community response to stress, which is a decrease in perennial brown algae and proliferation of opportunistic green algae. …”

Summary of the main outcomes of this study. by Andrea Timoncini (20390373)

“…The main aim of this study is to investigate the impact of accelerated ageing, mimicking a high-touch frequency by cyclic exposure to artificial sweat solution as well as to temperature and relative humidity variations, on the efficacy of Cu-based thin foils against <i>P</i>. …”

Sigma-1 receptors stabilize IRE1. by Tomohisa Mori (474320)

“…<p>(a) Sig-1R knockdown decreases phosphorylated IRE1 (pIRE1) in various types of cells when cells are under ER stress. …”

Data_Sheet_1_Notoginsenoside Fc ameliorates renal tubular injury and mitochondrial damage in acetaminophen-induced acute kidney injury partly by regulating SIRT3/SOD2 pathway.docx by Miaomiao Wei (168145)

“…Notoginsenoside Fc (Fc), a new saponin isolated from Panax notoginseng, exhibited numerous pharmacological actions. …”

Table1_Novel multitarget analgesic candidate SZV-1287 demonstrates potential disease-modifying effects in the monoiodoacetate-induced osteoarthritis mouse model.docx by Ádám István Horváth (15443678)

“…Then, SZV-1287 (20 mg/kg/day) or its vehicle was injected intraperitoneally over a 21-day period.</p>Results<p>MIA induced remarkable weight bearing and paw withdrawal threshold decrease, alterations in the tibial and femoral structures (decreased trabeculation and cortical erosions), histopathological damage (disorganized cartilage structure, hypocellularity, decreased matrix staining, disrupted tidemark integrity, synovial hyperplasia, and osteophyte formation), and changes in the astrocyte and microglia density in the lumbar spinal cord.…”