DataSheet1.pdf by Vincent Portero (518206)

“…Using computer simulations employing a multicellular in silico model, we furthermore demonstrate that the experimentally observed increase in K_V4.3 current and concurrent decrease in Na_V1.5 current may result in a loss of conduction, underlining the potential functional relevance of our findings. …”

Table11_BuShen HuoXue decoction improves fertility through intestinal hsp-16.2-mediated heat-shock signaling pathway in Caenorhabditis elegans.DOCX by Kanglu Wu (16009853)

“…</p><p>Methods: Bisphenol A (BPA, 175 μg/mL) was used to establish a fertility-defective C. elegans model. …”

Data_Sheet_1_Sleep in 21-Day Dry Immersion. Are Cardiovascular Adjustments Rapid Eye Movement Sleep-Dependent?.docx by Evgeny Yu. Bersenev (11605863)

“…<p>Introduction: A decrease in sleep quality and duration during space missions has repeatedly been reported. …”

Data_Sheet_3_Stochastic partial budget analysis of strategies to reduce the prevalence of lung lesions in finishing pigs at slaughter.pdf by Josefine Jerlström (13957386)

“…A partial budget analysis was then performed in which the baseline farm was compared with two hypothetical strategies aimed at reducing the occurrence and spread of respiratory diseases during pig production: (S1) avoiding mixing of litters after weaning and (S2) keeping purchased pregnant gilts separated from sows during gestation, farrowing and lactation. …”

Image 4_Wip1 inhibitor CCT007093 alleviates immune exhaustion of lymphocytes via p65 NF-κB and YY1 in chronic hepatitis B virus infection in mice.tif by Yu-Syuan You (21288113)

“…</p>Methods<p>We focused on CCT007093, a Wip1 inhibitor, screened for its distinctive capacity to simultaneously decrease PD-1 and FcγRIIB expression in B cells.…”

Table 1_High-dose medium-term HMB supplementation did not trigger body composition changes in trained and untrained males under usual conditions or high-intensity functional exerci... by Krzysztof Durkalec-Michalski (4691311)

“…Nevertheless, there was an impact (p < 0.05) from training status (but not HMB/PLA) on FM (kg; slight increases in UTR) and TBW (slight decreases in UTR).</p>Discussion<p>The individually adjusted high HMB dose did not change body mass and composition in trained or untrained individuals during a three-week exclusive supplementation or three-week supplementation in combination with additional HIFT stimuli. …”

Cytotoxic activity. by Xiaopei Lin (8993858)

“…<div><p>Necrotizing enterocolitis (NEC) is a severe intestinal disease of the newborn infants, associated with high morbidity and mortality. …”

Synthesis and X‑ray Crystallography of [Mg(H₂O)₆][AnO₂(C₂H₅COO)₃]₂ (An = U, Np, or Pu) by Viktor N. Serezhkin (1591696)

“…Actinide contraction in the series of U­(VI)–Np­(VI)–Pu­(VI) in compounds <b>I</b>–<b>III</b> is reflected in a decrease in the mean AnO bond lengths and in the volume and sphericity degree of Voronoi–Dirichlet polyhedra of An atoms.…”

Data Sheet 1_Effects of Long-term low-dose intermittent rapamycin administration on glucose metabolism and immune system of SAMP8 and SAMR1 mice.docx by Luiz Adriano Damasceno Queiroz (18116671)

“…In SAMR1 mice, RAPA administration led to a decrease in CD3⁺ thymocytes and splenic lymphoproliferative capacity, while also enhanced mitochondrial performance. …”

Table1_BuShen HuoXue decoction improves fertility through intestinal hsp-16.2-mediated heat-shock signaling pathway in Caenorhabditis elegans.DOC by Kanglu Wu (16009853)

“…</p><p>Methods: Bisphenol A (BPA, 175 μg/mL) was used to establish a fertility-defective C. elegans model. …”

Mechanistic framework predicts drug-class specific utility of antiretrovirals for HIV prophylaxis by Sulav Duwal (152805)

“…However, poor translatability of animal- and <i>ex vivo</i>/<i>in vitro</i> experiments, and the necessity to conduct long-term (several years) human trials involving considerable sample sizes (N>1000 individuals) are major obstacles to rationalize drug-candidate selection. We developed a prophylaxis modelling tool that mechanistically considers the mode-of-action of all available drugs. …”

Chronic Intermittent Hypoxia Is Independently Associated with Reduced Postoperative Opioid Consumption in Bariatric Patients Suffering from Sleep-Disordered Breathing by Alparslan Turan (2336)

“…Percentage of total sleep time spent at SaO₂ < 90% was inversely associated with total postoperative opioid consumption; a 5-%- absolute increase in the former would relatively decrease median opioid consumption by 16% (98.75% CI: 2% to 28%, P = 0.006). …”

Downregulation of COP9 signalosome subunits differentially affects the CSN complex and target protein stability-5 by Andreas Peth (85734)

“…Whereas the anti-CSN5 antibody revealed a reduction to 23% as compared to the control, there was no decrease of the CSN complex observed with the anti-CSN8 antibody. …”

Table_2_Endurance Training Counteracts the High-Fat Diet-Induced Profiling Changes of ω-3 Polyunsaturated Fatty Acids in Skeletal Muscle of Middle-Aged Rats.pdf by Ting Li (117885)

“…</p>Results<p>Rats fed a high-fat diet exhibited decreased overall amount of ω-3 PUFAs in soleus muscle, while endurance training preserved the total amount of ω-3 PUFAs. …”

Supplementary Material for: Changes in Stroke Patients’ Health-Seeking Behavior by COVID-19 Epidemic Regions: Data from the Korean Stroke Registry by Jeong H.-Y. (4161082)

“…During the COVID-19 period, the D-G region had two-thirds the number of cases (vs. the pre-CO­VID-19 period) and a significant decrease in the proportion of patients with TIA (9.97%–2.91%). …”

Data_Sheet_1_miR-124-3p Suppresses the Invasiveness and Metastasis of Hepatocarcinoma Cells via Targeting CRKL.pdf by Abbasi Majid (9377765)

“…Mechanistic investigations showed that CRKL downregulation suppresses the ERK pathway and EMT process, and concomitant decrease in invasion and metastasis of HCC cells. The expressions of key molecules in the ERK pathway such as RAF, MEK, ERK1/2, and pERK1/2 and key promoters of EMT such as N-cadherin and vimentin were downregulated, whereas E-cadherin, a key suppression indicator of EMT, was upregulated. …”

Data_Sheet_1_Hydroxyurea Scavenges Free Radicals and Induces the Expression of Antioxidant Genes in Human Cell Cultures Treated With Hemin.DOCX by Sânzio Silva Santana (9136571)

“…Significant increases in expression were observed in genes with kinase activity: protein kinase C beta (PRKCB), zeta (PRKCZ) and phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta (PIK3C2B). HU also induced a significant increase in expression of the gene p62/sequestosome (p62/SQSTM1) and a significant decrease in the expression of the transcriptional factor BACH1 in HUVECs. …”

DataSheet1_The Effect of Mesenchymal Stromal Cells Derived From Endometriotic Lesions on Natural Killer Cell Function.docx by Fawaz Abomaray (11858087)

“…Reduced immunosurveillance of these lesions has been proposed to be playing a role in the pathology of endometriosis. Mesenchymal stromal cells (MSC) are found in ectopic lesions and may decrease immunosurveillance. …”

New advances in <i>DPYD</i> genotype and risk of severe toxicity under capecitabine - Fig 3 by Marie-Christine Etienne-Grimaldi (413881)

“…<p>Distribution of pre-treatment plasma UH2/U ratio (A) and Uracil concentrations (B) for the 205 patients with validated phenotypic data, according to <i>DPYD</i> variants of interest: variant *2A (3 heterozygous patients), D949V (3 heterozygous patients), R592W (1 heterozygous patient), D342G (1 heterozygous patient), HapB3 (4 heterozygous patients), 166VV (3 homozygous patients) <i>vs</i> any other variations (185 patients) <i>vs</i> no variation (5 patients). …”

The Layout Measures of Micro-sprinkler Irrigation under Plastic Film Regulate Tomato Soil Bacterial Community and Root System by mingzhi zhang (14330205)

“…The L1C2 treatment had a stable bacterial community structure and good root morphological development, which positively promoted the increase of tomato yield. …”