Discovery of <i>N</i>‑((3<i>S</i>,4<i>S</i>)‑4-(3,4-Difluorophenyl)piperidin-3-yl)-2-fluoro-4-(1-methyl‑1<i>H</i>‑pyrazol-5-yl)benzamide (Hu7691), a Potent and Selective Akt Inhibitor That Enables Decrease of Cutaneous Toxicity by Jinxin Che (791250)

Discovery of <i>N</i>‑((3<i>S</i>,4<i>S</i>)‑4-(3,4-Difluorophenyl)piperidin-3-yl)-2-fluoro-4-(1-methyl‑1<i>H</i>‑pyrazol-5-yl)benzamide (Hu7691), a Potent and Selective Akt Inhibitor That Enables Decrease of Cutaneous Toxicity by Jinxin Che (791250)

Tract-based spatial statistics analyses identified white matter areas affected by a significant decrease in fractional anisotropy (FA) in patients with psychotic bipolar disorder (PBD) (N = 29), non-psychotic bipolar disorder (NPBD) (N = 23), and bipolar disorder (BD) (N = 52) in comparisons with healthy controls (HCs) (N = 65). by Dong-Kyun Lee (497757)

Discovery of <i>N</i>‑((3<i>S</i>,4<i>S</i>)‑4-(3,4-Difluorophenyl)piperidin-3-yl)-2-fluoro-4-(1-methyl‑1<i>H</i>‑pyrazol-5-yl)benzamide (Hu7691), a Potent and Selective Akt Inhibitor That Enables Decrease of Cutaneous Toxicity by Jinxin Che (791250)

Discovery of <i>N</i>‑((3<i>S</i>,4<i>S</i>)‑4-(3,4-Difluorophenyl)piperidin-3-yl)-2-fluoro-4-(1-methyl‑1<i>H</i>‑pyrazol-5-yl)benzamide (Hu7691), a Potent and Selective Akt Inhibitor That Enables Decrease of Cutaneous Toxicity by Jinxin Che (791250)

Patients’ baseline hemodynamic and metabolic variables and changes during fluid bolus according to a decrease (or not) in central venous-to-arterial carbon dioxide tension difference (P_vaCO₂) > 2 mmHg (P_vaCO₂ non-responders and responders). by Charalampos Pierrakos (8941559)

Discovery of <i>N</i>‑((3<i>S</i>,4<i>S</i>)‑4-(3,4-Difluorophenyl)piperidin-3-yl)-2-fluoro-4-(1-methyl‑1<i>H</i>‑pyrazol-5-yl)benzamide (Hu7691), a Potent and Selective Akt Inhibitor That Enables Decrease of Cutaneous Toxicity by Jinxin Che (791250)

Chart illustrates the treated groups (BM-MSC1, BM-MSC2, AD-MSC1, AD-MSC2) increasing in cell viability over replicates, while the untreated groups (Un-BM1, Un-BM2, Un-AD1, Un-AD2) show a gradual decrease. by Alani Mohanad Khalid Ahmed (22693496)

Table1_Familial Hypercholesterolemia: Real-World Data of 1236 Patients Attending a Czech Lipid Clinic. A Retrospective Analysis of Experience in More than 50 years. Part I: Genetic... by Veronika Todorovova (12157917)

“…Differences were also found in the effects of various APOE isoforms on lipid lowering. A significant decrease in lipid parameters was observed with the E2E2 isoform whereas a minimal decrease was seen with the E4E4 and E3E3 isoforms.…”

DataSheet1_Familial Hypercholesterolemia: Real-World Data of 1236 Patients Attending a Czech Lipid Clinic. A Retrospective Analysis of Experience in More than 50 years. Part I: Gen... by Veronika Todorovova (12157917)

“…Differences were also found in the effects of various APOE isoforms on lipid lowering. A significant decrease in lipid parameters was observed with the E2E2 isoform whereas a minimal decrease was seen with the E4E4 and E3E3 isoforms.…”

Image1_Familial Hypercholesterolemia: Real-World Data of 1236 Patients Attending a Czech Lipid Clinic. A Retrospective Analysis of Experience in More than 50 years. Part I: Genetic... by Veronika Todorovova (12157917)

“…Differences were also found in the effects of various APOE isoforms on lipid lowering. A significant decrease in lipid parameters was observed with the E2E2 isoform whereas a minimal decrease was seen with the E4E4 and E3E3 isoforms.…”

The tip-proximal chromosome follows the extending vegetative hyphae tip. by Agnieszka Kois-Ostrowska (3558563)

“…Minus sign means that the distance between the chromosome and the tip is increasing and a plus sign that it is decreasing. Data were analyzed using a mixed effects model, which can compensate for the effect of individual hyphae and a standard linear model. …”

Cluster analysis of the spatial distribution of heterochromatin and euchromatin after irradiation with 0.5 Gy and 3.5 Gy. by Yang Zhang (30734)

“…We observe a decrease in the ratio of the clustered points 6 h after irradiation for both doses. 24 h after irradiation these changes are reverted. …”

Changes in fine roots biomass (A), coarse roots biomass (B), and belowground biomass (C) of sessile oak saplings (n = 72) treated under ambient (400 ppm CO2) and elevated (700 ppm... by Janko Arsić (11597145)

Data sample demographics. Note that AP refers to anti-psychotic medication, and AD refers to anti-depressive medication. Thus, AP and AD in this table refer to the percentage of pa... by Eloy Geenjaar (21533195)

Forest fragmentation as a function of the proportion of forest cover <i>PFC</i> in 10 x 10 km cells in Peninsular Spain. by Marta Rueda (740022)

“…The lower solid and discontinuous lines (95% CIs) correspond to a polynomial regression on 100 cells located at the lower edge of the cloud of points. …”

Examples of drawings made by children in the M2 –after the first field trip (a, b) and M3 –after the second field trip and laboratory class (c, d). by Maria João Feio (11169654)

CB1 receptor blockade ameliorates hepatic fat infiltration and inflammation and increases Nrf2-AMPK pathway in a rat model of severely uncontrolled diabetes - Fig 1 by Eugene Chang (180832)

MYCN cofactors assist MYCN to bind to DNA. by Zhihui Liu (95891)

“…<p>(<b>A</b>) Western blot analysis shows that <i>WDR5</i> knockdown using siRNAs for 72 h decreases in WDR5 protein with no effect on MYCN expression. …”

Longitudinal antibody responses for each nursing home resident (Georgia, December 2020–July 2022; n = 37). by Zeshan A. Chisty (18388200)