Mitochondrial Ca²⁺ uptake contributes to cell death induced by Aβ oligomers. by Sara Sanz-Blasco (271498)

“…<p><i>A</i>. Cerebellar granule cells were co-loaded with mitotracker green and TMRM 10 nM and washed. …”

Subsistence-level groups experiencing lifestyle change are a potential model for uncovering GxE interactions. by Amanda J. Lea (11790137)

“…Bidirectional arrows indicate factors that could either increase or decrease during urban transitions. (<b>B</b>) Studies such as The Turkana Health and Genomics Project [<a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3002311#pbio.3002311.ref018" target="_blank">18</a>,<a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3002311#pbio.3002311.ref019" target="_blank">19</a>], The Orang Asli Health and Lifeways Project [<a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3002311#pbio.3002311.ref020" target="_blank">20</a>], The Pacific Planetary Health Initiative, Madagascar Health and Environmental Research [<a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3002311#pbio.3002311.ref021" target="_blank">21</a>–<a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3002311#pbio.3002311.ref023" target="_blank">23</a>], The Tsimane Health and Life History Project [<a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3002311#pbio.3002311.ref024" target="_blank">24</a>], and The Shuar Health and Life History Project [<a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3002311#pbio.3002311.ref025" target="_blank">25</a>,<a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3002311#pbio.3002311.ref026" target="_blank">26</a>] all combine anthropological and biomedical data collection in transitioning societies and are thus poised to uncover GxE interactions in the context of evolutionary mismatch. …”

AntagomiR-treated flies display metabolic defects similar to miR-275/305 mutants. by Junfei Xie (3148638)

“…<p>(A) miRNA inhibition efficiency was determined by qRT-PCR at 2 d post antagomiR injection with scrambled sequences as negative controls (Ant-NC). …”

Electrospun Polyimide Nanofiber-Based Triboelectric Nanogenerator for Harvesting Energy at Elevated Temperatures by Feilong Shi (13803714)

“…The PINF-TENG generated an open-circuit voltage of 60.83 V and a short-circuit current of 1.52 μA at 25 °C, and a peak power density of 17.36 mW/m² was achieved on a 50 MΩ external load. …”

Discovery of the Diphenyl 6‑Oxo-1,6-dihydropyridazine-3-carboxylate/carboxamide Analogue J27 for the Treatment of Acute Lung Injury and Sepsis by Targeting JNK2 and Inhibiting the... by Jing Liao (193197)

“…The optimal compound <b>J27</b> decreased the release of TNF-α and IL-6 in mouse and human cells J774A.1 and THP-1 (IL-6 IC₅₀ = 0.22 μM) through the NF-κB/MAPK pathway. …”

Discovery of the Diphenyl 6‑Oxo-1,6-dihydropyridazine-3-carboxylate/carboxamide Analogue J27 for the Treatment of Acute Lung Injury and Sepsis by Targeting JNK2 and Inhibiting the... by Jing Liao (193197)

“…The optimal compound <b>J27</b> decreased the release of TNF-α and IL-6 in mouse and human cells J774A.1 and THP-1 (IL-6 IC₅₀ = 0.22 μM) through the NF-κB/MAPK pathway. …”

Label-Free Interactome Analysis Revealed an Essential Role of CUL3-KEAP1 Complex in Mediating the Ubiquitination and Degradation of PHD2 by Ang Luo (8097296)

“…Prolyl hydroxylase domain-containing protein 2 (PHD2/EGLN1) is a key regulatory enzyme that plays a fundamental role in the cellular hypoxic response pathway, mediating proline hydroxylation-dependent protein degradation of selected target proteins. …”

Loss of ATRX and SLF2 enables telomere exchanges. by William A. Scott (11707932)

“…<p>A: DNA sequencing and western blotting confirming the disruption of ATRX expression in CRISPR-Cas9-edited HEK293 Flp-In T-REx cells inducibly expressing RAP1-BirA*. …”

Label-Free Interactome Analysis Revealed an Essential Role of CUL3-KEAP1 Complex in Mediating the Ubiquitination and Degradation of PHD2 by Ang Luo (8097296)

“…Prolyl hydroxylase domain-containing protein 2 (PHD2/EGLN1) is a key regulatory enzyme that plays a fundamental role in the cellular hypoxic response pathway, mediating proline hydroxylation-dependent protein degradation of selected target proteins. …”

Presentation_1_Utility of a Novel Three-Dimensional and Dynamic (3DD) Cell Culture System for PK/PD Studies: Evaluation of a Triple Combination Therapy at Overcoming Anti-HER2 Trea... by Anusha Ande (724831)

“…In the 3DD cell culture setting, sequential dosing of PAC then EVE+DAS showed a 5-fold increase in caspase-3 activity and 8.5-fold decrease in the total cell number compared to the control. …”

Phosphorylation of p27^Kip1 at S140 regulates its protein stability in the G1-phase of the cell cycle. by Erica K. Cassimere (3111996)

“…<p>(A) Ectopically expressed p27^Kip1 S140A mutant has a decreased half-life compared with the WT or phosphomimetic (S140D) versions. …”

Comparative Transcriptomic Analysis of Primary Duck Hepatocytes Provides Insight into Differential Susceptibility to DHBV Infection by Liang Yan (494300)

“…After re-annotation against human genome data, the 384 DEGs were pooled together with proteins belonging to hepatitis B pathway to construct a protein-protein interaction network. The combination of decreased expression of liver-specific genes (CYP3A4, CYP1E1, CFI, RELN and GSTA1 et al) with increased expression of hepatocyte-dedifferentiation-associated genes (PLA2G4A and PLCG1) suggested that <i>in vitro</i> culture conditions results in the fading of hepatocyte phenotype in PDHs. …”

mGluR1 activity regulates cell proliferation. by Malathi Banda (505556)

“…<p><b>A. Proliferation.</b> mGluR1 overexpression significantly increased proliferation of MCF10AT1 cells compared to the control as measured by MTT assay. …”

Source data. by Shihao Zhou (5774795)

“…Under wide-field imaging in primary somatosensory and visual cortices in mice with high labeling density (80–90%), SomaFRCaMPi exhibits up to 40% higher SNR and decreased artifactual correlation across neurons. Altogether, SomaFRCaMPi improves the accuracy and scale of neuronal activity imaging at single-neuron resolution in densely labeled brain tissues due to a 2–3-fold enhanced automated neuronal segmentation, 50% higher fraction of responsive cells, up to 2-fold higher SNR compared to jRGECO1a. …”

In vitro biophysical properties of red GECIs. by Shihao Zhou (5774795)

“…Under wide-field imaging in primary somatosensory and visual cortices in mice with high labeling density (80–90%), SomaFRCaMPi exhibits up to 40% higher SNR and decreased artifactual correlation across neurons. Altogether, SomaFRCaMPi improves the accuracy and scale of neuronal activity imaging at single-neuron resolution in densely labeled brain tissues due to a 2–3-fold enhanced automated neuronal segmentation, 50% higher fraction of responsive cells, up to 2-fold higher SNR compared to jRGECO1a. …”

Source data. by Shihao Zhou (5774795)

“…Under wide-field imaging in primary somatosensory and visual cortices in mice with high labeling density (80–90%), SomaFRCaMPi exhibits up to 40% higher SNR and decreased artifactual correlation across neurons. Altogether, SomaFRCaMPi improves the accuracy and scale of neuronal activity imaging at single-neuron resolution in densely labeled brain tissues due to a 2–3-fold enhanced automated neuronal segmentation, 50% higher fraction of responsive cells, up to 2-fold higher SNR compared to jRGECO1a. …”

Waterborne exposure to BPS causes thyroid endocrine disruption in zebrafish larvae by Dan-hua Zhang (3997844)

“…<div><p>Bisphenol S (BPS) is widely used as a raw material in industry, resulting in its ubiquitous distribution in natural environment, including the aqueous environment. …”

Pharmacology and Therapeutic Potential of Benzothiazole Analogues for Cocaine Use Disorder by Comfort A. Boateng (3617120)

“…This study focused on the synthesis and evaluation of a novel series of benzothiazole analogues designed to target D₄R. …”

MHC Ib molecule Qa-1 presents <i>Mycobacterium tuberculosis</i> peptide antigens to CD8⁺ T cells and contributes to protection against infection by Yao Bian (2820964)

“…T cells from Qa-1^-/- mice also had increased expression of inhibitory and apoptosis-associated cell surface markers such as CD94/NKG2A, KLRG1, PD-1, Fas-L, and CTLA-4. As such, they were more prone to cell death and had decreased capacity in promoting the killing of Mtb in infected macrophages. …”

Stabilization of p27^Kip1 through S140 phosphorylation is required for tumorsphere resistance to IR. by Erica K. Cassimere (3111996)

“…Differences between groups were evaluated using two-tailed Student <i>t</i> tests among replicate experiments; **P = 0.005. (E) p27S140A has a decreased half-life compared to p27WT in tumorspheres subjected to IR. …”