The correlation between external apical root resorption and electric pulp test responses: a prospective clinical trial by Farnaz YOUNESSIAN (12853367)

“…Conclusion: The relative decrease in electric pulp test level could be a diagnostic sign of root resorption during orthodontic treatment. …”

Identifying Insects with Incomplete DNA Barcode Libraries, African Fruit Flies (Diptera: Tephritidae) as a Test Case by Massimiliano Virgilio (182967)

“…In all cases, more restrictive distance thresholds produced a gradual increase in the proportion of true negatives, a gradual decrease of false positives and more abrupt variations in the proportions of true positives and false negatives. …”

Purification, characterization, and antitumor activity of a novel glucan from the fruiting bodies of <i>Coriolus Versicolor</i> by Annoor Awadasseid (3726955)

“…Structural analysis revealed that CVG has a linear α-glucan chain composed of only (1→ 6)-α-D-Glc<i>p</i>. …”

Discovery of the Diphenyl 6‑Oxo-1,6-dihydropyridazine-3-carboxylate/carboxamide Analogue J27 for the Treatment of Acute Lung Injury and Sepsis by Targeting JNK2 and Inhibiting the... by Jing Liao (193197)

“…The optimal compound <b>J27</b> decreased the release of TNF-α and IL-6 in mouse and human cells J774A.1 and THP-1 (IL-6 IC₅₀ = 0.22 μM) through the NF-κB/MAPK pathway. …”

Discovery of the Diphenyl 6‑Oxo-1,6-dihydropyridazine-3-carboxylate/carboxamide Analogue J27 for the Treatment of Acute Lung Injury and Sepsis by Targeting JNK2 and Inhibiting the... by Jing Liao (193197)

“…The optimal compound <b>J27</b> decreased the release of TNF-α and IL-6 in mouse and human cells J774A.1 and THP-1 (IL-6 IC₅₀ = 0.22 μM) through the NF-κB/MAPK pathway. …”

Label-Free Interactome Analysis Revealed an Essential Role of CUL3-KEAP1 Complex in Mediating the Ubiquitination and Degradation of PHD2 by Ang Luo (8097296)

“…Prolyl hydroxylase domain-containing protein 2 (PHD2/EGLN1) is a key regulatory enzyme that plays a fundamental role in the cellular hypoxic response pathway, mediating proline hydroxylation-dependent protein degradation of selected target proteins. …”

Loss of ATRX and SLF2 enables telomere exchanges. by William A. Scott (11707932)

“…<p>A: DNA sequencing and western blotting confirming the disruption of ATRX expression in CRISPR-Cas9-edited HEK293 Flp-In T-REx cells inducibly expressing RAP1-BirA*. …”

Label-Free Interactome Analysis Revealed an Essential Role of CUL3-KEAP1 Complex in Mediating the Ubiquitination and Degradation of PHD2 by Ang Luo (8097296)

“…Prolyl hydroxylase domain-containing protein 2 (PHD2/EGLN1) is a key regulatory enzyme that plays a fundamental role in the cellular hypoxic response pathway, mediating proline hydroxylation-dependent protein degradation of selected target proteins. …”

Phosphorylation of p27^Kip1 at S140 regulates its protein stability in the G1-phase of the cell cycle. by Erica K. Cassimere (3111996)

“…<p>(A) Ectopically expressed p27^Kip1 S140A mutant has a decreased half-life compared with the WT or phosphomimetic (S140D) versions. …”

Comparative Transcriptomic Analysis of Primary Duck Hepatocytes Provides Insight into Differential Susceptibility to DHBV Infection by Liang Yan (494300)

“…After re-annotation against human genome data, the 384 DEGs were pooled together with proteins belonging to hepatitis B pathway to construct a protein-protein interaction network. The combination of decreased expression of liver-specific genes (CYP3A4, CYP1E1, CFI, RELN and GSTA1 et al) with increased expression of hepatocyte-dedifferentiation-associated genes (PLA2G4A and PLCG1) suggested that <i>in vitro</i> culture conditions results in the fading of hepatocyte phenotype in PDHs. …”

mGluR1 activity regulates cell proliferation. by Malathi Banda (505556)

“…<p><b>A. Proliferation.</b> mGluR1 overexpression significantly increased proliferation of MCF10AT1 cells compared to the control as measured by MTT assay. …”

Source data. by Shihao Zhou (5774795)

“…Under wide-field imaging in primary somatosensory and visual cortices in mice with high labeling density (80–90%), SomaFRCaMPi exhibits up to 40% higher SNR and decreased artifactual correlation across neurons. Altogether, SomaFRCaMPi improves the accuracy and scale of neuronal activity imaging at single-neuron resolution in densely labeled brain tissues due to a 2–3-fold enhanced automated neuronal segmentation, 50% higher fraction of responsive cells, up to 2-fold higher SNR compared to jRGECO1a. …”

In vitro biophysical properties of red GECIs. by Shihao Zhou (5774795)

“…Under wide-field imaging in primary somatosensory and visual cortices in mice with high labeling density (80–90%), SomaFRCaMPi exhibits up to 40% higher SNR and decreased artifactual correlation across neurons. Altogether, SomaFRCaMPi improves the accuracy and scale of neuronal activity imaging at single-neuron resolution in densely labeled brain tissues due to a 2–3-fold enhanced automated neuronal segmentation, 50% higher fraction of responsive cells, up to 2-fold higher SNR compared to jRGECO1a. …”

Source data. by Shihao Zhou (5774795)

“…Under wide-field imaging in primary somatosensory and visual cortices in mice with high labeling density (80–90%), SomaFRCaMPi exhibits up to 40% higher SNR and decreased artifactual correlation across neurons. Altogether, SomaFRCaMPi improves the accuracy and scale of neuronal activity imaging at single-neuron resolution in densely labeled brain tissues due to a 2–3-fold enhanced automated neuronal segmentation, 50% higher fraction of responsive cells, up to 2-fold higher SNR compared to jRGECO1a. …”

Waterborne exposure to BPS causes thyroid endocrine disruption in zebrafish larvae by Dan-hua Zhang (3997844)

“…<div><p>Bisphenol S (BPS) is widely used as a raw material in industry, resulting in its ubiquitous distribution in natural environment, including the aqueous environment. …”

Pharmacology and Therapeutic Potential of Benzothiazole Analogues for Cocaine Use Disorder by Comfort A. Boateng (3617120)

“…This study focused on the synthesis and evaluation of a novel series of benzothiazole analogues designed to target D₄R. …”

NRG1-II stimulates neurogenesis through ErbB4 as a cell-extrinsic signal. by Tomomi Sato (301255)

“…The approximate site of the section is shown in a lateral view in the inset. <b>E</b>. A decrease in Tyr¹¹⁶²-phosphorylated ErbB4 (pErbB4) in the OT of MO^{<i>nrg1IIE1</i>}-injected embryos (<i>nrg1IIE1</i>) compared to the control MO^{<i>nrg1IIE15m</i>}-injected embryos (<i>nrg1IIE15m</i>) at 40 hpf. …”

MMV291 disrupts actin-dependent apicoplast segregation and induces a partial delayed death phenotype. by Madeline G. Dans (14193815)

“…<b>ii</b> These images were quantified by 3 independent blind scorers, which showed a significant decrease in the normal segregation of apicoplasts between the 10 μM MMV291 and DMSO treatments, while the 5 μM MMV291 was not significant (ns). …”

Knockdown of Appa, Appb, or Prp1 results in impaired development and death of head region. A–L. by Darcy M. Kaiser (114856)

“…S3</a>). The <i>appa</i> and <i>appb</i> splice blocking (SB) MOs used above (A–H) significantly decreases detection of protein species by the antibody 22C11 (top row). …”

A randomized controlled trial and prospective cohort investigating antivenom for red-bellied black snake envenomation by Geoffrey K. Isbister (8281572)

“…</p> <p>Administration of antivenom in red-bellied black snake envenomation within 6 hours post-bite appeared to decrease the proportion of patients with myotoxicity, but a third of patients had adverse reactions.…”