Data Sheet 1_Causal relationships between plasma lipidome and diabetic neuropathy: a Mendelian randomization study.xlsx by Zhaoxiang Wang (1603615)

“…Upon adjusting for multiple comparisons, higher levels of phosphatidylcholine (16:0_20:2) (OR = 0.82, 95%CI: 0.73-0.91; P < 0.001, FDR = 0.033) and phosphatidylcholine (16:1_18:1) (OR = 0.77, 95%CI: 0.67-0.88; P < 0.001, FDR = 0.019) are associated with a decreased risk of diabetic neuropathy. Further multivariable MR (MVMR) analysis demonstrated the effect of genetically predicted phosphatidylcholine (16:1_18:1) remained after adjusting for body mass index (BMI) and glycated hemoglobin (HbA1c). …”

Table_2_Dynamics of Genotypic and Phenotypic Antibiotic Resistance in a Conventional Wastewater Treatment Plant in 2 Years.xlsx by Hanseob Shin (13231800)

“…<p>Wastewater treatment plants (WWTPs) are considered a sink and a source of antibiotic resistance. In this study, we applied both culture-dependent and SmartChip-based culture-independent approaches for the investigation of antibiotic-resistant bacteria (ARB) and antibiotic resistance genes (ARGs) at Jungnang (JN), located in the Han River, Seoul, South Korea, for 2 years, i.e., 2017 and 2018. …”

Table3_SCG2 is a Prognostic Biomarker Associated With Immune Infiltration and Macrophage Polarization in Colorectal Cancer.xlsx by Hao Wang (39217)

“…Secretogranin II (SCG2) is a member of the chromogranin family of acidic secretory proteins, has a role in tumor microenvironment (TME) of lung adenocarcinoma and bladder cancer. …”

Data Sheet 2_Causal relationships between plasma lipidome and diabetic neuropathy: a Mendelian randomization study.xlsx by Zhaoxiang Wang (1603615)

“…Upon adjusting for multiple comparisons, higher levels of phosphatidylcholine (16:0_20:2) (OR = 0.82, 95%CI: 0.73-0.91; P < 0.001, FDR = 0.033) and phosphatidylcholine (16:1_18:1) (OR = 0.77, 95%CI: 0.67-0.88; P < 0.001, FDR = 0.019) are associated with a decreased risk of diabetic neuropathy. Further multivariable MR (MVMR) analysis demonstrated the effect of genetically predicted phosphatidylcholine (16:1_18:1) remained after adjusting for body mass index (BMI) and glycated hemoglobin (HbA1c). …”

Triangle collaboration assessment of autophagy, ER stress and hypoxia in leukemogenesis: a bright perspective on the molecular recognition of B-ALL by Fatemeh Feizi (7021427)

“…In B-ALL group, <i>BECN1</i>, <i>HIF1A</i> and <i>ERN1</i> expressions were significantly down-regulated, while <i>BCL2</i> expression was up-regulated compared to the control group (<i>p</i> < .05). …”

The anti-proliferative activity of BTG2 and TOB1 requires interactions with Caf1a/Caf1b. by Rachel Doidge (114249)

“…(C) Schematic diagram of TOB1 and BTG2 indicating the position of phosphorylation sites of TOB1 (Ser-152, Ser-154, Ser-164) and BTG2 (Ser-147 and Ser-149), which were altered to alanine (S→A). (D) Over-expression of BTG2 (S→A), but not of BTG2 W103A (S→A), decreases cell proliferation. …”

DataSheet1_The Kids Are Alright (?). Infants’ Development and COVID-19 Pandemic: A Cross-Sectional Study.PDF by Eleonora Ferrari (9956010)

“…Language and personal-social-emotional subareas scores appeared the most affected. A decreasing trend of GDS along with the severity of restriction was observed.…”

Simulated vorticity of cell flows measured along a horizontal line, perpendicular to the primitive streak and crossing the center of the embryo. by Bakhtier Vasiev (212613)

“…<p>(<b>A</b>) From a simulation where S cells repel ST cells (mechanism M2), polarization off, growth off (see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0010571#pone-0010571-g007" target="_blank">Fig. 7</a>). …”

Table_1_Sodium Levels Predict Disability at Discharge in Guillain-Barré Syndrome: A Retrospective Cohort Study.pdf by Delia Gagliardi (6279221)

“…In conclusion, we found a significant, independent association between baseline serum sodium levels and severe disability at discharge in GBS patients. …”

table1_Molecules to Mountains: A Multi-Proxy Investigation Into Ancient Climate and Topography of the Pacific Northwest, USA.xlsx by Alexander McLean (10455737)

“…New paleosol carbonate stable isotope (δ¹⁸O) results from central Oregon are presented, along with published proxy data, including fossil teeth, smectites, and carbonate concretions. We interpret a polygenetic history of Cascade Mountain topographic uplift along-strike, characterized by: 1) Steady uplift of the Washington Cascades through the Cenozoic due long-term arc rotation and shortening against a Canadian buttress, and 2) Uplift of the Oregon Cascades to similar-to-modern elevations by the late Oligocene, followed by topographic stagnation as extension developed into the Neogene. …”

Image_3_Effects of Acupuncture on Behavioral Stereotypies and Brain Dopamine System in Mice as a Model of Tourette Syndrome.TIF by Lixue Lin (7496957)

“…In the present study, we used behavioral tests, Western blotting, double-immunofluorescence labeling, and fluorescence spectrophotometry to investigate whether acupuncture performed at acupoints “Baihui” (GV20) and “Yintang” (GV29) affected behavioral stereotypies and regulated the dopamine (DA) system in three different brain regions in Balb/c mice injected with 3,3′-iminodipropionitrile (IDPN) as a model for TS. We found that acupuncture alleviated behavioral stereotypies, down-regulated the expression of D1R and D2R in the striatum (STR) and substantia nigra pars compacta (SNpc), and decreased the concentration of DA in the STR, SNpc, and prefrontal cortex (PFC) as well. …”

Supplementary Material for: Novel surgical treatment of an intraretinal juxtapapillary hemangioblastoma using intraocular diathermy forceps: A case report by vanOverdam K.A. (17059389)

“…This case report discusses the effectiveness and safety of a novel surgical technique using intraocular bipolar diathermy forceps to coagulate feeder and draining blood vessels of an intraretinal JRH. …”

Effects of Neurotrophic Support and Amyloid-Targeted Combined Therapy on Adult Hippocampal Neurogenesis in a Transgenic Model of Alzheimer's Disease by Christopher D. Morrone (3234888)

“…<div><p>Although it is recognized that multi-drug therapies may be necessary to combat AD, there is a paucity of preclinical proof of concept studies. …”

Hypoxia Negatively Regulates Antimetastatic PEDF in Melanoma Cells by a Hypoxia Inducible Factor-Independent, Autophagy Dependent Mechanism by Asunción Fernández-Barral (175687)

“…Importantly, although downregulation of PEDF was induced by inhibition of 2-oxoglutarate-dependent dioxygenases, it was independent of the hypoxia inducible factor (HIF), a key mediator of the adaptation to hypoxia. Decreased PEDF protein was not mediated by inhibition of translation through untranslated regions (UTRs) in melanoma cells. …”

Blocking NF-κB nuclear import prevents Tat±morphine-induced cytokine release by astrocytes (A–C). by Nazira El-Hage (375304)

Data Sheet 4_Causal relationships between plasma lipidome and diabetic neuropathy: a Mendelian randomization study.docx by Zhaoxiang Wang (1603615)

“…Upon adjusting for multiple comparisons, higher levels of phosphatidylcholine (16:0_20:2) (OR = 0.82, 95%CI: 0.73-0.91; P < 0.001, FDR = 0.033) and phosphatidylcholine (16:1_18:1) (OR = 0.77, 95%CI: 0.67-0.88; P < 0.001, FDR = 0.019) are associated with a decreased risk of diabetic neuropathy. Further multivariable MR (MVMR) analysis demonstrated the effect of genetically predicted phosphatidylcholine (16:1_18:1) remained after adjusting for body mass index (BMI) and glycated hemoglobin (HbA1c). …”

Image_2_Ameliorative and Synergic Effects of Derma-H, a New Herbal Formula, on Allergic Contact Dermatitis.tif by Si Yeon Jo (9116843)

“…Also, NGF expression decreased by NT and a mixture of AM and NT. Additionally, series of TrkA, Raf-1, MEK, and ERK were significantly inhibited by topical AM and NT application. …”

Image_1_Effects of Acupuncture on Behavioral Stereotypies and Brain Dopamine System in Mice as a Model of Tourette Syndrome.TIF by Lixue Lin (7496957)

“…In the present study, we used behavioral tests, Western blotting, double-immunofluorescence labeling, and fluorescence spectrophotometry to investigate whether acupuncture performed at acupoints “Baihui” (GV20) and “Yintang” (GV29) affected behavioral stereotypies and regulated the dopamine (DA) system in three different brain regions in Balb/c mice injected with 3,3′-iminodipropionitrile (IDPN) as a model for TS. We found that acupuncture alleviated behavioral stereotypies, down-regulated the expression of D1R and D2R in the striatum (STR) and substantia nigra pars compacta (SNpc), and decreased the concentration of DA in the STR, SNpc, and prefrontal cortex (PFC) as well. …”

Image2_SCG2 is a Prognostic Biomarker Associated With Immune Infiltration and Macrophage Polarization in Colorectal Cancer.PDF by Hao Wang (39217)

“…Secretogranin II (SCG2) is a member of the chromogranin family of acidic secretory proteins, has a role in tumor microenvironment (TME) of lung adenocarcinoma and bladder cancer. …”

Oligonucleotide array CGH in case 73, showing a ∼3.86 Mb deletion at chromosome 17q24. by Tomoko Fuke (393656)

“…<p>The black, the red, and the green dots denote signals indicative of the normal, the increased(>+0.5), and the decreased (< –1.0) copy numbers, respectively. The horizontal bar with arrowheads indicates a ∼2.3 Mb deletion identified in a patient with Carney complex and SRS-like phenotype <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0060105#pone.0060105-Blyth1" target="_blank">[44]</a>, and the black square represent a ∼65 kb segment harboring the breakpoint of a <i>de novo</i> translocation 46,XY,t(1;17)(q24;q23–q24) identified in a patient with SRS phenotype <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0060105#pone.0060105-Midro1" target="_blank">[45]</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0060105#pone.0060105-Drr1" target="_blank">[46]</a>.…”