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largest decrease » largest decreases (Expand Search), larger decrease (Expand Search), marked decrease (Expand Search)
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55001
Supplementary Material for: The E280A Presenilin Mutation Reduces Voltage-Gated Sodium Channel Levels in Neuronal Cells
Published 2017“…<b><i>Results:</i></b> The FAD-linked E280A mutation significantly decreased PS/γ-secretase-mediated processing of Na<sub>v</sub>β<sub>2</sub> as compared to wtPS1 controls, both in cells and in a cell-free system. …”
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55002
Data_Sheet_1_Effects of Polyunsaturated Fatty Acids Supplementation on the Meat Quality of Pigs: A Meta-Analysis.docx
Published 2021“…Our analysis found that PUFA supplementation increased the intramuscular fat (IMF) content (WMD = 0.467%, 95% CI: 0.312–0.621, p < 0.001), decreased the meat color L<sup>*</sup> (WMD = −0.636, 95% CI: −1.225 to −0.047, p = 0.034), and pH 24 h (WMD = −0.021, 95% CI: −0.032 to −0.009, p < 0.001) but had no influence on drip loss, meat color a<sup>*</sup> and b<sup>*</sup>, pH 45 min, and growth performance. …”
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55003
Table_2_Early life programming by diet can play a role in risk reduction of otitis in dogs.docx
Published 2023“…</p>Results<p>We report that eating a NPMD diet significantly decreased the risk of otitis later in life, while eating a UPCD diet significantly increased the risk. …”
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55004
Table 2_Tofacitinib extends survival in a mouse model of ALS through NK cell-independent mechanisms.xlsx
Published 2025“…Tofacitinib, an FDA-approved janus kinase (Jak) and signal transducer and activator (STAT) pathway inhibitor, reduces NK cytotoxicity and decreases overall levels in peripheral blood and may represent a potential ALS therapy. …”
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55005
Cellular N-myristoyltransferases play a crucial picornavirus genus-specific role in viral assembly, virion maturation, and infectivity
Published 2018“…Infection of HeLa cells with coxsackievirus B3 in the presence of this drug decreased VP0 acylation at least 100-fold, resulting in a defect both early and late in virus morphogenesis, which diminishes the yield of viral progeny by about 90%. …”
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55006
Table_1_The responses of soil microbial characteristics to nitrogen addition and biochar amendment in a Larix kaempferi plantation.docx
Published 2023“…The incorporation of biochar into soils is considered a potential strategy to enhance carbon (C) storage in soil and modify the impacts of N deposition. …”
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55007
Long-lived mice with reduced growth hormone signaling have a constitutive upregulation of hepatic chaperone-mediated autophagy
Published 2020“…Finally, we find Snell dwarf mice have decreased protein levels (in liver and kidney) of CIP2A, a well-characterized CMA target protein, without an associated change in <i>Cip2a</i> mRNA. …”
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55008
Table_1_Early life programming by diet can play a role in risk reduction of otitis in dogs.docx
Published 2023“…</p>Results<p>We report that eating a NPMD diet significantly decreased the risk of otitis later in life, while eating a UPCD diet significantly increased the risk. …”
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55009
Theta and gamma band frequencies vary with features of a double peaked g<sub>Ks</sub> spatial distribution.
Published 2021“…This was due to fact that the amount of bleed-over excitation from the active hotspot to the silent hotspot decreased as a function of distance between the hotspots. …”
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55010
Table 1_Tofacitinib extends survival in a mouse model of ALS through NK cell-independent mechanisms.xlsx
Published 2025“…Tofacitinib, an FDA-approved janus kinase (Jak) and signal transducer and activator (STAT) pathway inhibitor, reduces NK cytotoxicity and decreases overall levels in peripheral blood and may represent a potential ALS therapy. …”
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55011
Changes in breakfast frequency and composition during adolescence: The Adolescent Nutritional Assessment Longitudinal Study, a cohort from Brazil
Published 2018“…Consumption patterns of some foods/food groups have a tendency to become changed from initial to middle adolescence.…”
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55012
Data_Sheet_1_Age Dependence of Antimicrobial Resistance Among Fecal Bacteria in Animals: A Scoping Review.pdf
Published 2021“…<p>Introduction: A phenomenon of decreasing antimicrobial resistance (AMR) among fecal bacteria as food animals age has been noted in multiple field studies. …”
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55013
Blood Pressure Control with a Single-Pill Combination of Indapamide Sustained-Release and Amlodipine in Patients with Hypertension: The EFFICIENT Study
Published 2014“…The EFFICIENT study examines the efficacy and acceptability of a single-pill combination of sustained-release (SR) indapamide, a thiazide-like diuretic, and amlodipine, a calcium channel blocker (CCB), in the management of hypertension.…”
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55014
Modelling the “old” and the “new” databases simultaneously to estimate poaching trends for abalone in Zones A to G and Zones E to G
Published 2025“…The poaching indices for Zones A-G and Zones E-G show a decreasing trend from the highest estimates in 2018 and in 2018 - 2019 respectively, with a slight increase over the last two years.…”
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55015
Figure S1 - The RNA Degradation Pathway Regulates the Function of GAS5 a Non-Coding RNA in Mammalian Cells
Published 2013“…<p><b>Knockdown of UPF1 increases the expression level of GAS5, and decreases the glucocorticoid-responsive genes.</b> HEK293 cells were treated with a control siRNA or with a siRNA targeting UPF1. …”
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55016
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55017
Estimation of the requirement of sequencing depth for the detection of fetal aneuploidy in cell-free plasma as a function of fetal DNA fraction.
Published 2013“…With a sequencing throughput of ∼10 million sequence reads per channel on the flowcell, trisomy 21 can be detected if >3.9% of the cell-free DNA is fetal (dashed lines). …”
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55018
Increase in local adaptation as a function of the pollinator crossover probability, strength of selection, and precision of pollen transfer for both scenarios.
Published 2014“…<p>Top row (A–C): scenario 1, involving the pollinator pair “bimodal-low” + “bimodal-high”. …”
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55019
A model for how leptin and IL-6 regulate tube formation and cell proliferation in human lymphatic endothelial cells.
Published 2016“…As a result, proliferation of HDLECs is decreased, leading to inhibition of tube formation. …”
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55020