Image_3_Effects of Acupuncture on Behavioral Stereotypies and Brain Dopamine System in Mice as a Model of Tourette Syndrome.TIF by Lixue Lin (7496957)

“…In the present study, we used behavioral tests, Western blotting, double-immunofluorescence labeling, and fluorescence spectrophotometry to investigate whether acupuncture performed at acupoints “Baihui” (GV20) and “Yintang” (GV29) affected behavioral stereotypies and regulated the dopamine (DA) system in three different brain regions in Balb/c mice injected with 3,3′-iminodipropionitrile (IDPN) as a model for TS. We found that acupuncture alleviated behavioral stereotypies, down-regulated the expression of D1R and D2R in the striatum (STR) and substantia nigra pars compacta (SNpc), and decreased the concentration of DA in the STR, SNpc, and prefrontal cortex (PFC) as well. …”

Supplementary Material for: Novel surgical treatment of an intraretinal juxtapapillary hemangioblastoma using intraocular diathermy forceps: A case report by vanOverdam K.A. (17059389)

“…This case report discusses the effectiveness and safety of a novel surgical technique using intraocular bipolar diathermy forceps to coagulate feeder and draining blood vessels of an intraretinal JRH. …”

Effects of Neurotrophic Support and Amyloid-Targeted Combined Therapy on Adult Hippocampal Neurogenesis in a Transgenic Model of Alzheimer's Disease by Christopher D. Morrone (3234888)

“…<div><p>Although it is recognized that multi-drug therapies may be necessary to combat AD, there is a paucity of preclinical proof of concept studies. …”

Hypoxia Negatively Regulates Antimetastatic PEDF in Melanoma Cells by a Hypoxia Inducible Factor-Independent, Autophagy Dependent Mechanism by Asunción Fernández-Barral (175687)

“…Importantly, although downregulation of PEDF was induced by inhibition of 2-oxoglutarate-dependent dioxygenases, it was independent of the hypoxia inducible factor (HIF), a key mediator of the adaptation to hypoxia. Decreased PEDF protein was not mediated by inhibition of translation through untranslated regions (UTRs) in melanoma cells. …”

Blocking NF-κB nuclear import prevents Tat±morphine-induced cytokine release by astrocytes (A–C). by Nazira El-Hage (375304)

Data Sheet 4_Causal relationships between plasma lipidome and diabetic neuropathy: a Mendelian randomization study.docx by Zhaoxiang Wang (1603615)

“…Upon adjusting for multiple comparisons, higher levels of phosphatidylcholine (16:0_20:2) (OR = 0.82, 95%CI: 0.73-0.91; P < 0.001, FDR = 0.033) and phosphatidylcholine (16:1_18:1) (OR = 0.77, 95%CI: 0.67-0.88; P < 0.001, FDR = 0.019) are associated with a decreased risk of diabetic neuropathy. Further multivariable MR (MVMR) analysis demonstrated the effect of genetically predicted phosphatidylcholine (16:1_18:1) remained after adjusting for body mass index (BMI) and glycated hemoglobin (HbA1c). …”

Image_2_Ameliorative and Synergic Effects of Derma-H, a New Herbal Formula, on Allergic Contact Dermatitis.tif by Si Yeon Jo (9116843)

“…Also, NGF expression decreased by NT and a mixture of AM and NT. Additionally, series of TrkA, Raf-1, MEK, and ERK were significantly inhibited by topical AM and NT application. …”

Image_1_Effects of Acupuncture on Behavioral Stereotypies and Brain Dopamine System in Mice as a Model of Tourette Syndrome.TIF by Lixue Lin (7496957)

“…In the present study, we used behavioral tests, Western blotting, double-immunofluorescence labeling, and fluorescence spectrophotometry to investigate whether acupuncture performed at acupoints “Baihui” (GV20) and “Yintang” (GV29) affected behavioral stereotypies and regulated the dopamine (DA) system in three different brain regions in Balb/c mice injected with 3,3′-iminodipropionitrile (IDPN) as a model for TS. We found that acupuncture alleviated behavioral stereotypies, down-regulated the expression of D1R and D2R in the striatum (STR) and substantia nigra pars compacta (SNpc), and decreased the concentration of DA in the STR, SNpc, and prefrontal cortex (PFC) as well. …”

Image2_SCG2 is a Prognostic Biomarker Associated With Immune Infiltration and Macrophage Polarization in Colorectal Cancer.PDF by Hao Wang (39217)

“…Secretogranin II (SCG2) is a member of the chromogranin family of acidic secretory proteins, has a role in tumor microenvironment (TME) of lung adenocarcinoma and bladder cancer. …”

Oligonucleotide array CGH in case 73, showing a ∼3.86 Mb deletion at chromosome 17q24. by Tomoko Fuke (393656)

“…<p>The black, the red, and the green dots denote signals indicative of the normal, the increased(>+0.5), and the decreased (< –1.0) copy numbers, respectively. The horizontal bar with arrowheads indicates a ∼2.3 Mb deletion identified in a patient with Carney complex and SRS-like phenotype <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0060105#pone.0060105-Blyth1" target="_blank">[44]</a>, and the black square represent a ∼65 kb segment harboring the breakpoint of a <i>de novo</i> translocation 46,XY,t(1;17)(q24;q23–q24) identified in a patient with SRS phenotype <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0060105#pone.0060105-Midro1" target="_blank">[45]</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0060105#pone.0060105-Drr1" target="_blank">[46]</a>.…”

Table1_SCG2 is a Prognostic Biomarker Associated With Immune Infiltration and Macrophage Polarization in Colorectal Cancer.xlsx by Hao Wang (39217)

“…Secretogranin II (SCG2) is a member of the chromogranin family of acidic secretory proteins, has a role in tumor microenvironment (TME) of lung adenocarcinoma and bladder cancer. …”

Data Sheet 3_Causal relationships between plasma lipidome and diabetic neuropathy: a Mendelian randomization study.xlsx by Zhaoxiang Wang (1603615)

“…Upon adjusting for multiple comparisons, higher levels of phosphatidylcholine (16:0_20:2) (OR = 0.82, 95%CI: 0.73-0.91; P < 0.001, FDR = 0.033) and phosphatidylcholine (16:1_18:1) (OR = 0.77, 95%CI: 0.67-0.88; P < 0.001, FDR = 0.019) are associated with a decreased risk of diabetic neuropathy. Further multivariable MR (MVMR) analysis demonstrated the effect of genetically predicted phosphatidylcholine (16:1_18:1) remained after adjusting for body mass index (BMI) and glycated hemoglobin (HbA1c). …”

Table 1_Perioperative neurocognitive disorder in colorectal cancer surgery: a systematic review of incidence, mechanisms, and interventions.doc by Xiujin Huang (22637270)

“…Background<p>Perioperative neurocognitive disorder (PND) represents a significant impediment to postoperative recovery in patients undergoing colorectal cancer surgery, particularly among the elderly. …”

The Role of Platelet Factor 4 in Local and Remote Tissue Damage in a Mouse Model of Mesenteric Ischemia/Reperfusion Injury by Peter H. Lapchak (152602)

“…We also show that PF4 may modulate the release of IgA. Interestingly, we show that PF4 expression on intestinal epithelial cells is increased after IR at both the mRNA and protein levels. …”

Case management for people with acquired brain injury: feasibility and effectiveness of a two-year pragmatic randomized controlled trial by Annemarie P.M. Stiekema (8456988)

“…Unsuccessful monitoring may have hindered access to the case manager and prevented us from evaluating CM as a complex intervention. It remains a challenge to early identify those who could benefit from care coordination.…”

Data_Sheet_1_IL-6 During Influenza-Streptococcus pneumoniae Co-Infected Pneumonia—A Protector.pdf by Xuemei Gou (8333874)

Table_1_Study of Cinobufagin as a Promising Anticancer Agent in Uveal Melanoma Through Intrinsic Apoptosis Pathway.docx by Leilei Zhang (130338)

“…Cinobufagin, secreted by the Asiatic toad Bufo gargarizans, is a traditional Chinese medicine, widely used in tumor treatment. …”

Table_1_Dynamics of Genotypic and Phenotypic Antibiotic Resistance in a Conventional Wastewater Treatment Plant in 2 Years.xlsx by Hanseob Shin (13231800)

“…<p>Wastewater treatment plants (WWTPs) are considered a sink and a source of antibiotic resistance. In this study, we applied both culture-dependent and SmartChip-based culture-independent approaches for the investigation of antibiotic-resistant bacteria (ARB) and antibiotic resistance genes (ARGs) at Jungnang (JN), located in the Han River, Seoul, South Korea, for 2 years, i.e., 2017 and 2018. …”

table2_Molecules to Mountains: A Multi-Proxy Investigation Into Ancient Climate and Topography of the Pacific Northwest, USA.xlsx by Alexander McLean (10455737)

“…New paleosol carbonate stable isotope (δ¹⁸O) results from central Oregon are presented, along with published proxy data, including fossil teeth, smectites, and carbonate concretions. We interpret a polygenetic history of Cascade Mountain topographic uplift along-strike, characterized by: 1) Steady uplift of the Washington Cascades through the Cenozoic due long-term arc rotation and shortening against a Canadian buttress, and 2) Uplift of the Oregon Cascades to similar-to-modern elevations by the late Oligocene, followed by topographic stagnation as extension developed into the Neogene. …”

Quantification of faecal glucocorticoid metabolites as a measure of stress in the rock hyrax (Procavia capensis) living in an urban green space by Scheun, Juan (8229483)

“…Animal FID did not differ significantly between seasons but they did differ significantly between sections, and decreased in accordance with fGCM concentrations. The non-invasive approach established in this study provides a foundation for assessing rock hyrax wellbeing, and can help better understand how anthropogenic presence is perceived as a stressor in this species.…”