DNMT3A expression is regulated by cell-density, mitosis but not mitogenic growth factors. by Jia-Xin Jiang (442775)

“…(B) Nuclear expression of DNMT3A is decreased by the mitotic inhibitor nocodazole in cells. …”

Neuroprotection by α2-Adrenergic Receptor Stimulation after Excitotoxic Retinal Injury: A Study of the Total Population of Retinal Ganglion Cells and Their Distribution in the Chic... by Caridad Galindo-Romero (3110937)

“…The isodensity maps of normal retina showed that the density decreased with age as the retinal size increased. In contrast to previous studies, we did not find any specific region with increased RGC density, rather the Brn3a+ RGCs were homogeneously distributed over the central retina with decreasing density in the periphery and in the region of the pecten oculli. …”

Summary of LTP, LTD and behavioral tasks results. by Stephanie Jacobs (652579)

“…<p>The Tg-NRA^2B(CT) mice had enhanced LTP, as well as enhanced long-term recognition memory and contextual fear conditioning. The Tg-GluN2B^2A(CT) mice have significantly impaired LTD resulting in impaired short-term recognition memory and impaired long-term cued fear conditioning. …”

Validation of DEGs in UVA-irradiated S cells that are involved in skin senescence. by Seong-Wook Seo (5641799)

“…<p>(A) KEGG analysis shows the list of DEGs involved in Toll-like receptor signaling pathway. …”

Weight and Glucose Reduction Observed with a Combination of Nutritional Agents in Rodent Models Does Not Translate to Humans in a Randomized Clinical Trial with Healthy Volunteers... by Rebecca J. Hodge (297778)

“…In subjects with diabetes taking metformin, weight increased in the GSK457-treated group [adjusted mean % increase from baseline: 1.26% (95% CI: -0.24, 2.75)], and mean glucose and HbA1c were decreased slightly compared to placebo [adjusted mean glucose change from baseline: -1.22 mmol/L (95% CI: -2.45, 0.01); adjusted mean HbA1c change from baseline: -0.219% (95% CI: -0.910, 0.472)].…”

Matrix is a critical determinant of DNMT3A expression in visceral smooth muscle cells. by Jia-Xin Jiang (442775)

“…<p>SMC were plated on native (NC) or denatured collagen (DNC) at low density (4×10⁴ cells/mL) for 6 hours in EMEM with 6% FCS, then media was changed to 2% FCS in EMEM. (A) DNMT3A expression increases in the nucleus in response to denatured matrix, while α-smooth muscle actin (α-SMA) expression decreased. …”

Novel model for the manipulation of host responses by <i>Mycobacterium avium</i> subsp. <i>paratuberculosis</i> (MAP) for its survival during subclinical stages of Johne’s disease.... by Hyun-Eui Park (4047733)

“…Upregulation of PIP5K1C and downregulation of IL-17A, IL-17F, and IL-26 induces a loss of granuloma integrity, which can result in fecal shedding and dissemination of MAP. …”

<i>MptriA</i>, an Acetyltransferase Gene Involved in Pigment Biosynthesis in <i>M. purpureus</i> YY‑1 by Bin Liang (228729)

“…The Δ<i>MptriA</i> strain showed decreased pigment and citrinin production during the liquid-fermentation process. …”

Placental Proteomics Provides Insights into Pathophysiology of Pre-Eclampsia and Predicts Possible Markers in Plasma by Sheon Mary (3696952)

“…Some of the differentially expressed proteins were monitored in the plasma by multiple reaction monitoring analysis, which showed an increase in apolipoproteins A-I and A-II in gestational weeks 26–30 (2-fold, <i>p</i> < 0.01), while haptoglobin and hemopexin decreased in gestational weeks 26–30 and week 40/at delivery (1.8 fold, <i>p</i> < 0.01) in pre-eclamptic patients. …”

Placental Proteomics Provides Insights into Pathophysiology of Pre-Eclampsia and Predicts Possible Markers in Plasma by Sheon Mary (3696952)

“…Some of the differentially expressed proteins were monitored in the plasma by multiple reaction monitoring analysis, which showed an increase in apolipoproteins A-I and A-II in gestational weeks 26–30 (2-fold, <i>p</i> < 0.01), while haptoglobin and hemopexin decreased in gestational weeks 26–30 and week 40/at delivery (1.8 fold, <i>p</i> < 0.01) in pre-eclamptic patients. …”

Placental Proteomics Provides Insights into Pathophysiology of Pre-Eclampsia and Predicts Possible Markers in Plasma by Sheon Mary (3696952)

“…Some of the differentially expressed proteins were monitored in the plasma by multiple reaction monitoring analysis, which showed an increase in apolipoproteins A-I and A-II in gestational weeks 26–30 (2-fold, <i>p</i> < 0.01), while haptoglobin and hemopexin decreased in gestational weeks 26–30 and week 40/at delivery (1.8 fold, <i>p</i> < 0.01) in pre-eclamptic patients. …”

Transporter inhibitor MK571 inhibited the generation and excretion of demethoxycurcumin-<i>O</i>-glucuronides in HeLa1A1 cells. by Beibei Zhang (509356)

“…<p>(A) MK571 (5 and 20 μM) inhibited the excretion of demethoxycurcumin-<i>O</i>-glucuronides (G1) in extracellular medium; (B) Inhibitory effects of MK571 (5 and 20 μM) on the excretion of demethoxycurcumin-<i>O</i>-glucuronides (G2) in extracellular solution; (C) MK571 (5 and 20 μM) decreased the efflux excretion rates of G1 and G2; (D) MK571 (5 and 20 μM) evaluated the intracellular levels of G1 and G2; (E) MK571 (5 and 20 μM) reduced the overall formation (<i>f</i>_met) of G1 and G2 in HeLa1A1 cell; The concentration of demethoxycurcumin was 4 μM. …”

Example of a raw sEMG signal of the gastrocnemius muscle. by I. Moll (14227650)

Dissection of the regulatory role for the N-terminal domain in <i>Candida albicans</i> protein phosphatase Z1 by Krisztina Szabó (3860470)

“…The deletion of the N-terminal 1–16 amino acids and the G2A mutation significantly decreased the specific activity of the enzyme. …”

Presentation_1_Transitional B Cells and TLR9 Responses Are Defective in Selective IgA Deficiency.PDF by Andri L. Lemarquis (5148806)

“…Finally, CpG stimulation failed to induce IgA production in IgAD individuals. Collectively, our results demonstrate a defect of the TLR9 responses in IgAD that leads to B cell dysregulation and decreased IgA production.…”

Integrated Metabolomics and Lipidomics Analyses Reveal Metabolic Reprogramming in Human Glioma with IDH1 Mutation by Lina Zhou (473857)

“…The lower fatty acyl pool may be mediated by the lower protein expression levels of long-chain acyl-CoA synthetase 1 (ACSL1), ACSL4, and very long-chain acyl-CoA synthetase 3 (ACSVL3) in <i>IDH1</i> mutant glioma. …”

DataSheet_1_Role of ADAM10 and ADAM17 in the Regulation of Keratinocyte Adhesion in Pemphigus Vulgaris.docx by Daniela Kugelmann (625708)

“…In primary human keratinocytes, inhibition of ADAM10, but not ADAM17, reduced loss of cell adhesion and fragmentation of Dsg1 and Dsg3 immunostaining in response to a PV1-IgG from a mucocutaneous PV patient. Similarly, inhibition of ADAM10 in dissociation assay decreased fragmentation of primary keratinocytes induced by a monoclonal antibody against Dsg3 and by PV-IgG from two other patients both suffering from mucosal PV. …”

The Oncogene PDRG1 Is an Interaction Target of Methionine Adenosyltransferases by Claudia Pérez (351604)

“…Increased <i>Pdrg1</i> expression is detected in acute liver injury and hepatoma cells, together with decreased <i>Mat1a</i> expression and nuclear accumulation of MATα1. …”

Video_1_Mechanical digit sensory stimulation: a randomized control trial on neurological and motor recovery in acute stroke.MP4 by Shuting Zhang (436486)

“…</p>Results<p>After 12 days of intervention, the IL-17A, TNF-α, and NIHSS levels were significantly decreased, while the VEGF-A, MMSE, FMA, and MBI levels were significantly increased in both disease groups. …”

Data_Sheet_1_Characterization of Enterovirus Associated m6A RNA Methylation in Children With Neurological Symptoms: A Prospective Cohort Study.docx by Danping Zhu (6758192)

“…The different m6A RNA methylation was increased in the transcriptome’s CDS regions but decreased in both the 3′UTRs and stop codon among the NS group. …”