image1_Changes in Efficacy Indicators for Adalimumab Biosimilar Candidate (HS016) for the Treatment of Active Ankylosing Spondylitis at Various Time Points.tif by Jinmei Su (4604059)

“…Among these indicators, chest expansion showed a significant increase at each time point compared with baseline, whereas all other efficacy indicators showed significant decreases compared with baseline at each time point (all p < 0.05). …”

DSB formation is altered in <i>dot-1</i>.<i>1</i> mutant worms. by Laura I. Lascarez-Lagunas (8275293)

“…Between 4 and 6 gonads were scored per genotype. A significant decrease in levels of RAD-51 foci were observed for zones 4 to 7 in <i>dot-1</i>.…”

Data_Sheet_1_The timelines for the price and reimbursement authorization in Italy 2018–2020.pdf by Valentina Gallo (95843)

“…In 2020, the overall process duration for Off-patent pharmaceuticals procedures was equal to 129.8 average days [95% CI: (122.3–137.2)], with a median value of 108.0, whereas for In-patent pharmaceuticals procedures, it was equal to 283.1 average days [95% CI: (267.8–298.5)], with a median value of 284.0. …”

The complete workflow employed in this study. by Md. Mostafa Kamal (13514317)

“…Furthermore, mCSM and DynaMut2 analyses indicated a decrease in ΔΔG stability for the mutants. GeneMANIA and STRING networks highlighted correlations with <i>CD86</i> and <i>CD80</i> genes. …”

Prognosis for Hospitalized Patients with Systemic Lupus Erythematosus in China: 5-Year Update of the Jiangsu Cohort by Xuebing Feng (293563)

“…<div><p>Objective</p><p>To identify early signs associated with poor prognosis in Chinese patients with systemic lupus erythematosus (SLE) through a large population-based follow-up study.</p><p>Methods</p><p>Medical records of > 2,500 SLE patients that first hospitalized between 1999–2009 were collected from 26 centers across Jiangsu province, China, and entered into a database. …”

Data_Sheet_1_Age-Related Changes in the Gut Microbiota Modify Brain Lipid Composition.pdf by Mayssa Albouery (8294364)

“…Gut colonization by microbiota of old mice resulted in a significant increase in total monounsaturated fatty acids (MUFA) and a significant decrease in the relative amounts of cholesterol and total polyunsaturated fatty acids (PUFA) in the cortex. …”

Table_2_Dynamic immune status analysis of peripheral blood mononuclear cells in patients with Klebsiella pneumoniae bloodstream infection sepsis using single-cell RNA sequencing.xl... by Shengwei Zhang (321384)

“…</p>Results<p>During K. pneumoniae acute infection we observed a decrease in the proportion of T cells, most probably due to apoptosis and the function of T cell subtypes was disorder. …”

Data Sheet 1_16S rRNA and metabolomics reveal the key microbes and key metabolites that regulate diarrhea in Holstein male calves.docx by P. P. Cao (20565548)

“…</p>Results<p>Our findings indicated a high prevalence of diarrhea among calves between 1–4 weeks of age on pasture, which led to a marked decrease in growth performance, including average daily gain. …”

Data_Sheet_1_Liraglutide Alleviates Hepatic Steatosis by Activating the TFEB-Regulated Autophagy-Lysosomal Pathway.PDF by Yunyun Fang (9698396)

“…<p>Liraglutide, a glucagon-like peptide-1 receptor agonist (GLP-1RA), has been demonstrated to alleviate non-alcoholic fatty liver disease (NAFLD). …”

Data_Sheet_1_SPT20 Regulates the Hog1-MAPK Pathway and Is Involved in Candida albicans Response to Hyperosmotic Stress.docx by Lianfang Wang (8477508)

“…Here, we investigated the role of SPT20 in response to osmotic stress. Testing a C. albicans spt20Δ/Δ mutant, we found it was sensitive to osmotic stress. …”

Table_1_ThCOL2 Improves the Salt Stress Tolerance of Tamarix hispida.docx by Xiaojin Lei (9190101)

“…Overexpression of the ThCOL2 gene in plants under 150 mM NaCl stress increased the ability of transgenic T. hispida cells to remove reactive oxygen species (ROS) by regulating the activity of protective enzymes and promoting a decrease in the accumulation of O^2– and H₂O₂, thereby reducing cell damage or cell death and enhancing salt tolerance. …”

Metabolomics Analysis Identifies Intestinal Microbiota-Derived Biomarkers of Colonization Resistance in Clindamycin-Treated Mice by Robin L. P. Jump (591535)

“…Of 484 compounds analyzed, 146 (30%) exhibited a significant increase or decrease in concentration during clindamycin treatment followed by recovery to baseline that coincided with restoration of <i>in vivo</i> colonization resistance. …”

Table_5_Dynamic immune status analysis of peripheral blood mononuclear cells in patients with Klebsiella pneumoniae bloodstream infection sepsis using single-cell RNA sequencing.xl... by Shengwei Zhang (321384)

“…</p>Results<p>During K. pneumoniae acute infection we observed a decrease in the proportion of T cells, most probably due to apoptosis and the function of T cell subtypes was disorder. …”

Illustration of the mean-shift model. by Fabrice P. Cordelières (168644)

“…The size of the sectors will increase or decrease (indicated by the arrows) as a function of cell shape modifications. …”

Image_4_Modulation of the skin microbiome in cutaneous T-cell lymphoma delays tumour growth and increases survival in the murine EL4 model.jpg by Saptaswa Dey (18312400)

“…Intriguingly, we observed a significant decrease in Staphylococcus aureus frequency (p = 0.0001) but an increase in the overall detection frequency of the Staphylococcus genus, indicating that antibiotic treatment helped regain the microbial balance and increased the number of non-pathogenic Staphylococcus populations. …”

Image 1_Exploring the liver microenvironment following successful therapy for HCV: gene expression profiling and residual T cell infiltration.tif by Daniel E. Millian (20296458)

“…In parallel, spectral imaging further revealed post-treatment shifts in macrophage populations, with a significant decrease in inflammatory subsets (CD14+, CD14+/Mac387+, p<0.05) and an increase in anti-inflammatory subsets (CD16+, CD16+/CD163+, CD16+/CD68+, p<0.05). …”

Image_2_Modulation of the skin microbiome in cutaneous T-cell lymphoma delays tumour growth and increases survival in the murine EL4 model.jpg by Saptaswa Dey (18312400)

“…Intriguingly, we observed a significant decrease in Staphylococcus aureus frequency (p = 0.0001) but an increase in the overall detection frequency of the Staphylococcus genus, indicating that antibiotic treatment helped regain the microbial balance and increased the number of non-pathogenic Staphylococcus populations. …”

Inhibition of α_vβ₃ integrin induces loss of cell directionality of oral squamous carcinoma cells (OSCC) by Cyntia F. Montenegro (3947582)

“…<div><p>The connective tissue formed by extracellular matrix (ECM) rich in fibronectin and collagen consists a barrier that cancer cells have to overpass to reach blood vessels and then a metastatic site. …”

Table_1_Changes and Challenges in Inpatient Mental Health Care During the First Two High Incidence Phases of the COVID-19 Pandemic in Germany – Results From the COVID Ψ Psychiatry... by Hauke Felix Wiegand (12465030)

“…The results showed a median decrease of inpatient treatment to 80% of 2019 levels and of day hospital treatment to 50% (first phase) and 70% (second phase). …”

Image_3_Dynamic immune status analysis of peripheral blood mononuclear cells in patients with Klebsiella pneumoniae bloodstream infection sepsis using single-cell RNA sequencing.jp... by Shengwei Zhang (321384)

“…</p>Results<p>During K. pneumoniae acute infection we observed a decrease in the proportion of T cells, most probably due to apoptosis and the function of T cell subtypes was disorder. …”