S1 File - by Chang-sheng Liao (18591969)

“…<div><p>Objective</p><p>To elucidate potential molecular mechanisms differentiating osteoarthritis (OA) and rheumatoid arthritis (RA) through a bioinformatics analysis of differentially expressed genes (DEGs) in patient synovial cells, aiming to provide new insights for clinical treatment strategies.…”

Image_2_Endocannabinoid signaling regulates post-operative delirium through glutamatergic mediodorsal thalamus-prelimbic prefrontal cortical projection.TIF by Yang Liu (4829)

“…Background<p>Post-operative delirium (POD), a common post-operative complication that affects up to 73. 5% of surgical patients, could prolong hospital stays, triple mortality rates, cause long-term cognitive decline and dementia, and boost medical expenses. …”

Mutation of the WNK RFSV motif does not affect WNK kinase activity or ion and fluid transport by the Malpighian tubules. by Prathibha Yarikipati (17131843)

“…<b>(B)</b> Quantification of relative SPAK phosphorylation normalized to control (<i>w</i>^{<i>Berlin</i>}) in standard bathing medium for each independent replicate showed the expected decrease in tubule Wnk activity upon <i>Wnk</i> knockdown and increase in hypotonic medium compared to standard bathing medium, but no difference in activity in <i>Wnk</i>^<i>AA</i>/ <i>Wnk</i>^<i>MB</i> mutants compared to controls in standard bathing or hypotonic conditions. n = 5. ***, p<0.001; ****, p<0.0001, one-sample t-test to a theoretical mean of 1 (for comparisons to control in standard bathing medium) or two-sided t-test (for other comparisons). …”

Image_1_Endocannabinoid signaling regulates post-operative delirium through glutamatergic mediodorsal thalamus-prelimbic prefrontal cortical projection.TIF by Yang Liu (4829)

“…Background<p>Post-operative delirium (POD), a common post-operative complication that affects up to 73. 5% of surgical patients, could prolong hospital stays, triple mortality rates, cause long-term cognitive decline and dementia, and boost medical expenses. …”

AKAP13 scaffolds PKA and mTORC1 in close proximity. by Shihai Zhang (703122)

“…<b>(<i>D</i>)</b> Elevated full-length AKAP13 levels decrease mTORC1 activity. Empty vector (EV), Flag-tagged AKAP13 full-length (FL), or different Flag-tagged AKAP13 truncations (1–1387, 1388–2190, 2191–2817) were overexpressed in HEK293A cells for 24 hours. mTORC1 activity was analyzed by protein immunoblotting for the phosphorylation status of S6K1 (pS6K1). …”

The impact of excessive DNA amounts used for bisulfite conversion on the amplification efficiency and the methylation level of <i>LINE-1</i> and <i>Alu</i>. by Trang Thi Quynh Tran (20485595)

“…(<b>D, E</b>) An increase in methylation level of <i>LINE-1</i> (D) and <i>Alu</i> (E) was associated with a decrease in DNA input for bisulfite conversion. …”

Table 1_Variations in vitamin D status among Chinese children aged 1–6 years during the COVID-19 pandemic.xlsx by Yongfeng Qiao (3354326)

“…Additionally, the concentrations of 25(OH)D in spring exhibited a decrease during the COVID-19 pandemic (37.9 ± 10.3 ng/ml) in comparison to the pre-pandemic measurements (39.3 ± 9.9 ng/ml) (p = 0.008), while winter concentrations increased from (35.1 ± 10.4 ng/ml) to (37.9 ± 10.3 ng/ml) during the pandemic (p = 0.002).…”

β-NAD increases intracellular cAMP concentration via soluble adenylyl cyclase, but this pathway is not essential for the relaxing effect. by Innokentij Jurastow (22430601)

“…<p>(A, B) Recording of intracellular cAMP concentration in HBSMC via FRET, with low FRET ratio indicating high cAMP concentration. β-NAD and isoproterenol cause a decrease in FRET ratio, reflecting rise in intracellular cAMP concentration. …”

Image_4_Endocannabinoid signaling regulates post-operative delirium through glutamatergic mediodorsal thalamus-prelimbic prefrontal cortical projection.TIF by Yang Liu (4829)

“…Background<p>Post-operative delirium (POD), a common post-operative complication that affects up to 73. 5% of surgical patients, could prolong hospital stays, triple mortality rates, cause long-term cognitive decline and dementia, and boost medical expenses. …”

Supplementary Material for: Systematic Review and Meta-Analysis of the Impact of Hypoxia on Infarcted Myocardium: Better or Worse? by Pang B. (5404793)

“…Overall, chronic hypoxia was found to have a beneficial effect on the ejection fraction (standard mean difference [SMD] = 5.39; 95% confidence interval [CI], 3.83 to 6.95; <i>P</i> < 0.001) of the infarcted heart, whereas acute hypoxia significantly improved hemodynamics, as indicated by an increase in the maximal rate of rise of left ventricular pressure (SMD = 1.27; 95% CI, 0.27 to 2.28; <i>P</i> = 0.013) and cardiac output (SMD = 1.26; 95% CI, 0.34 to 2.18; <i>P</i> = 0.007) and a decrease in total systematic vascular resistance (SMD = –0.89; 95% CI, –1.24 to –0.53; <i>P</i> < 0.001). …”

Signature of Aberrant DNA Methylation in <i>MYC</i>-Induced T cell Lymphomas by Rene Opavsky (32415)

“…<div><p>(A) Schematic representation of transgenes in <i>MYC</i>-induced T cell lymphoma model used in this study.…”

Significance of the Wnt canonical pathway in radiotoxicity <i>via</i> oxidative stress of electron beam radiation and its molecular control in mice by Shashank Kumar (8916584)

“…Post-irradiation likewise influences the morphology of sperm. The decrease in mRNA levels of Lef1, Axin2, Survivin, Ku70, and XRCC6 levels suggests radiation inhibits the Wnt canonical pathway and failure in DNA repair mechanisms in a coupled manner. …”

Motion of FisB clusters is not coupled to cell wall synthesis, or pH and voltage gradients across the cell membrane. by The PLOS Biology Staff (11836235)

“…Upon treatment with fosfomycin, GFP-Mbl filaments stop moving, which is reflected as a decrease in asymmetry (<i>p</i> = 0.0044), whereas mGFP-FisB’s motion is unaffected (<i>p</i> = 0.8655). …”

Boxplot of the OA group before batch correction. by Chang-sheng Liao (18591969)

“…<div><p>Objective</p><p>To elucidate potential molecular mechanisms differentiating osteoarthritis (OA) and rheumatoid arthritis (RA) through a bioinformatics analysis of differentially expressed genes (DEGs) in patient synovial cells, aiming to provide new insights for clinical treatment strategies.…”

Table1_2-Dimensional in vitro culture assessment of ovarian cancer cell line using cost effective silver nanoparticles from Macrotyloma uniflorum seed extracts.DOCX by Kousalya Lavudi (11838779)

“…Propidium iodide-based Cell cycle study has shown a significant decrease in G0/G1 phase compared to control (88.8%), which further confirmed the apoptotic induction. …”

Related to Fig 3. Neither <i>Catalase</i> nor <i>Sod1</i> overexpression restore cytoskeletal loops to <i>NDUFS7</i>-deficient animals. by Bhagaban Mallik (12459375)

“…The motor neuron-depleted <i>NDUFS7[RNAi]</i> larvae showed a decrease in the number of Futsch-positive loops as compared to the Gal4 control. …”

DataSheet_1_Canagliflozin alters the gut, oral, and ocular surface microbiota of patients with type 2 diabetes mellitus.xls by Limin Wang (87511)

“…</p>Clinical parameters<p>A significant decrease in fasting plasma glucose (8.22 ± 2.19 vs 6.87 ± 1.09 mmol/L), glycated serum protein [291.00 (264.00, 353.00) vs 275.00 (251.00, 342.50) μmol/L], hemoglobin A1c (7.39 ± 1.18 vs 7.12 ± 1.33%), body mass index (25.32 ± 2.99 vs 24.83 ± 2.95 kg/m²), systolic blood pressure (129.05 ± 17.51 vs 123.43 ± 14.82 mmHg), and urinary creatinine [158.40 (74.75, 219.15) vs 79.70 (56.25, 138.10) μmmol/kg] levels was noted after 30-day Cana monotherapy (P < 0.05).…”

Boxplot of the RA group after batch correction. by Chang-sheng Liao (18591969)

“…<div><p>Objective</p><p>To elucidate potential molecular mechanisms differentiating osteoarthritis (OA) and rheumatoid arthritis (RA) through a bioinformatics analysis of differentially expressed genes (DEGs) in patient synovial cells, aiming to provide new insights for clinical treatment strategies.…”

4-methylthiobutyl isothiocyanate synergize the antiproliferative and pro-apoptotic effects of paclitaxel in human breast cancer cells by Harneetpal Kaur (13973217)

“…In western blot experiment, the combination had a significant decrease in Bcl-xl protein level, whereas a higher level of p53, cleaved caspase-3, and cleaved caspase-9 proteins compared to individual treatment in <i>T</i>-47D cells. …”

Table_1_Neutrophil Extracellular Traps in SARS-CoV2 Related Pneumonia in ICU Patients: The NETCOV2 Study.DOCX by Mathieu Godement (10180910)

“…<p>Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a poorly understood disease involving a high inflammatory status. …”