Presentation_1_Precision immunointerception of EGFR-driven tumorigenesis for lung cancer prevention.pptx by Jing Pan (95938)

“…In this study, we identified immunogenic epitopes for the common EGFR mutations in humans and formulated a multi-peptide vaccine (E^mut Vax) targeting the EGFR L858R, T790M, and Del19 mutations. …”

Table2_Bioinformatic analysis and experimental validation identified DNA methylation–Related biomarkers and immune-cell infiltration of atherosclerosis.XLSX by Congjian Xu (587410)

“…Western blot was performed to detect the protein expression levels of monocyte markers.</p><p>Results: A total of 110, 695 DMPs, and 918 DMRs were screened in the whole genome. …”

Data_Sheet_1_Differential stability of bacterial photosynthetic apparatus of Rhodobacter alkalitolerans strain JA916T under alkaline and light environment.zip by Mohammad Yusuf Zamal (16540509)

“…The content of bacteriochlorophyll a, absorbance spectra, and circular dichroism data shows that the integrity of photosystem complexes is less affected in hpH compared with npH conditions. …”

<i>Drosophila</i> Adiponectin Receptor in Insulin Producing Cells Regulates Glucose and Lipid Metabolism by Controlling Insulin Secretion by Su-Jin Kwak (145770)

“…This study demonstrates a new adipokine signaling in <i>Drosophila</i> and provides insights for the mammalian adiponectin receptor function in pancreatic beta cells, which could be useful for therapeutic application.…”

Data_Sheet_1_Gut Microbiome Reveals Specific Dysbiosis in Primary Osteoporosis.docx by Zhiming Xu (1271712)

“…<p>Object: Primary osteoporosis (PO) is the most common bone disease, which is characterized by decreased bone mass, damage of bone tissue microstructure, increased bone fragility, and is prone to fracture. …”

Environmental regulation of <i>CO1</i> and <i>CO2</i> transcription in mature <i>P. deltoides</i>. by Chuan-Yu Hsu (137979)

“…<p>(A) Abundance of <i>CO1</i> transcripts increased (<i>P</i>≤0.0002) under short days (SD) in leaves of field-grown trees (two genotypes), but showed no significant (<i>P</i>>0.05) difference under SD in growth rooms. …”

Table_1_MRVI1 and NTRK3 Are Potential Tumor Suppressor Genes Commonly Inactivated by DNA Methylation in Cervical Cancer.doc by Huihui Ji (653945)

“…Candidate hypermethylated/down-regulated TSGs were further evaluated and pyrosequencing was used to confirm their difference in methylation levels of selected TSGs in cervical cancer patients. A total of 25946 differentially methylated CpGs corresponding to 2686 hypermethylated genes and 4898 hypomethylated genes between cervical cancer and adjacent normal cervical tissues were found in this study. …”

Data_Sheet_1_The economic impact of porcine reproductive and respiratory syndrome outbreak in four Chinese farms: Based on cost and revenue analysis.docx by Zhendong Zhang (722744)

“…This study aimed to analyze and quantify the economic losses of the four PRRS outbreaks in Chinese herds. A straightforward approach was used to calculate additional costs and decreased revenues based on the PRRS-induced production deficiencies by average cost-of-production indices calculated from annual estimates of costs between 2014 and 2017. …”

Image 7_An analysis of the global burden of gallbladder and biliary tract cancer attributable to high BMI in 204 countries and territories: 1990–2021.tif by Zhuowen Hu (20431616)

“…High Body Mass Index (BMI) is a significant risk factor, contributing substantially to GBTC mortality and Disability-Adjusted Life Years (DALYs). …”

DataSheet_4_Melatonin Attenuates Sepsis-Induced Small-Intestine Injury by Upregulating SIRT3-Mediated Oxidative-Stress Inhibition, Mitochondrial Protection, and Autophagy Induction... by Siqi Xu (429196)

“…We confirmed this mechanistic effect in a CLP-induced sepsis model of intestinal SIRT3 conditional-knockout mice, and found that melatonin preserved mitochondrial function and induced autophagy of small-intestine epithelial cells; these effects were dependent on SIRT3 activation. …”

Circulating Microvesicles Are Elevated Acutely following Major Burns Injury and Associated with Clinical Severity by Kieran P. O’Dea (3391385)

“…In this pilot investigation, we measured circulating microvesicle levels following severe burns, with severe sepsis patients as a comparator group. We hypothesized that levels of circulating vascular cell-derived microvesicles are elevated acutely following burns injury, mirroring clinical severity due to the early onset and prevalence of systemic inflammatory response syndrome (SIRS) in these patients. …”

Table_4_Alterations of the gut microbiota in patients with immunoglobulin light chain amyloidosis.xlsx by Jipeng Yan (8473710)

“…Notably, 5 optimal ASV-based microbial markers were identified as the diagnostic model of AL amyloidosis and the AUC value of the train set and the test set was 0.8549 (95% CI 0.7310-0.9789) and 0.8025 (95% CI 0.5771-1), respectively. With a median follow-up of 19.0 months, further subgroup analysis also demonstrated some key gut microbial markers were related to disease severity, treatment response, and even prognosis of patients with AL amyloidosis.…”

Table2_Correlation Between Immune-Related Genes and Tumor-Infiltrating Immune Cells With the Efficacy of Neoadjuvant Chemotherapy for Breast Cancer.XLSX by Yan Zhou (6523)

“…Among the many biomarkers predicting the efficacy of NAC, immune-related biomarkers, such as immune-related genes and tumor-infiltrating lymphocytes (TILs), play a key role.</p><p>Methods: We analyzed gene expression from several datasets in the Gene Expression Omnibus (GEO) database and evaluated the relative proportion of immune cells using the CIBERSORT method. …”

Image 3_Mitochondrial mass and mitochondrial membrane potential of peripheral lymphocytes: promising biomarkers of systemic lupus erythematosus.pdf by Guanfei Zhao (3815596)

“…CD8⁺ T naïve (Tn) cell MMP-Low, CD8⁺ T effector memory cell MMP-Low, CD8⁺ T central memory (Tcm) cell MMP-Low, and SCMM-CD8⁺ Tn cells demonstrated a moderate diagnostic value for SLE, with an area under the curve (AUC) above 0.8. …”

Role of DNA methylation regulation of miR-130b expression in human lung cancer using bioinformatics analysis by Jin Wang (29560)

“…Data also demonstrated that confounding factors such as tumor clinical stages and tumor invasion depth markedly affected miR-130b expression levels in cancer patients. A total of 169 target genes modified by miR-130b expression were identified by using 4 online websites for target gene prediction. …”

Elevated levels of autoantibodies against EXD2 and PHAX in the sera of patients with chronic thromboembolic pulmonary hypertension by Akira Naito (663843)

“…Initial screening was performed in 5 CTEPH patients and 5 healthy donors (HDs) using a ProtoArray Human Protein Microarray v5.1 containing 9,375 human proteins, and we selected 34 antigens recognized by IgG antibodies more strongly in the sera of CTEPH patients than in the sera of HDs. …”

Image_1_Gut Microbiome and Bile Acid Metabolism Induced the Activation of CXCR5+ CD4+ T Follicular Helper Cells to Participate in Neuromyelitis Optica Spectrum Disorder Recurrence.... by Xi Cheng (296756)

“…Herein, we reported several key observations. First, there was a lower frequency of circulating Tfh cells in patients with an ARR of<1 than in those with an ARR of ≥1 (P< 0.05). …”

MicroRNA Stability in FFPE Tissue Samples: Dependence on GC Content by Yu Kakimoto (311787)

“…The unequal degradation of each miRNA affected the abundance ranking in the library, and miR-133a was shown to be the most abundant in FFPE cardiac tissues instead of miR-1, which was predominant before fixation. …”

Data_Sheet_1_Age-Related Changes in Pain Perception Are Associated With Altered Functional Connectivity During Resting State.pdf by Ana M. González-Roldán (5506694)

“…In conclusion, these findings suggest a compensatory mechanism for the sensory changes that typically accompanies aging. …”

Uterine Expression of NDRG4 Is Induced by Estrogen and Up-Regulated during Embryo Implantation Process in Mice by Qian Yang (300330)

“…NDRG4 (N-myc down-regulated gene 4) is a tumor suppressor that participates in cell survival, tumor invasion and angiogenesis. …”