PHF23 (plant homeodomain finger protein 23) negatively regulates cell autophagy by promoting ubiquitination and degradation of E3 ligase LRSAM1 by Zhenda Wang (412280)

“…<p>Autophagy is a multistep process that involves the degradation and digestion of intracellular components by the lysosome. …”

S1 Raw data - by Luciano Adorini (2094139)

“…<div><p>The nuclear farnesoid X receptor (FXR), a master regulator of bile acid and metabolic homeostasis, is a key target for treatment of nonalcoholic steatohepatitis (NASH). …”

Novel DNA Aptamer for CYP24A1 Inhibition with Enhanced Antiproliferative Activity in Cancer Cells by Madhu Biyani (12427332)

“…Overexpression of the vitamin D3-inactivating enzyme CYP24A1 (cytochrome P450 family 24 subfamily and hereafter referred to as CYP24) can cause chronic kidney diseases, osteoporosis, and several types of cancers. …”

Novel DNA Aptamer for CYP24A1 Inhibition with Enhanced Antiproliferative Activity in Cancer Cells by Madhu Biyani (12427332)

“…Overexpression of the vitamin D3-inactivating enzyme CYP24A1 (cytochrome P450 family 24 subfamily and hereafter referred to as CYP24) can cause chronic kidney diseases, osteoporosis, and several types of cancers. …”

Novel DNA Aptamer for CYP24A1 Inhibition with Enhanced Antiproliferative Activity in Cancer Cells by Madhu Biyani (12427332)

“…Overexpression of the vitamin D3-inactivating enzyme CYP24A1 (cytochrome P450 family 24 subfamily and hereafter referred to as CYP24) can cause chronic kidney diseases, osteoporosis, and several types of cancers. …”

Novel DNA Aptamer for CYP24A1 Inhibition with Enhanced Antiproliferative Activity in Cancer Cells by Madhu Biyani (12427332)

“…Overexpression of the vitamin D3-inactivating enzyme CYP24A1 (cytochrome P450 family 24 subfamily and hereafter referred to as CYP24) can cause chronic kidney diseases, osteoporosis, and several types of cancers. …”

Novel DNA Aptamer for CYP24A1 Inhibition with Enhanced Antiproliferative Activity in Cancer Cells by Madhu Biyani (12427332)

“…Overexpression of the vitamin D3-inactivating enzyme CYP24A1 (cytochrome P450 family 24 subfamily and hereafter referred to as CYP24) can cause chronic kidney diseases, osteoporosis, and several types of cancers. …”

Data_Sheet_1_Opportunities and Challenges From Leading Trends in a Biomonitoring Project: Canadian Health Measures Survey 2007–2017.xls by Yi-Sheng Chao (4383916)

“…None of the 20 biomarkers with the largest increases or decreases between cycles were associated with BMI.…”

Data_Sheet_2_Opportunities and Challenges From Leading Trends in a Biomonitoring Project: Canadian Health Measures Survey 2007–2017.xls by Yi-Sheng Chao (4383916)

“…None of the 20 biomarkers with the largest increases or decreases between cycles were associated with BMI.…”

In vitro evaluation of Neosetophomone B inducing apoptosis in cutaneous T cell lymphoma by targeting the FOXM1 signaling pathway by Kuttikrishnan, Shilpa

“…FOXM1 and BUB1B expression exhibited a dose-dependent reduction in NSP-B-treated CTCL cells.FOXM1 silencing decreased cell viability and increased apoptosis via BUB1B downregulation. …”
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Proper Notch signaling is required for the differentiation of <i>agr2</i>^<i>+</i> epidermal mucous cells and <i>pvalb8</i>-positive cells. by Yu-Fen Lu (171691)

“…<p><b>(A).</b> Substantial reductions in <i>pvalb8</i>-positive cell numbers were observed in the trunks and yolks of <i>mib</i>^<i>ta52b</i> and <i>mib</i>^<i>tfi91</i> mutants compared with sibling wild-types at 24 hpf. …”

While <i>agr2</i>^<i>+</i> EMC numbers are not altered in <i>jag1a</i> mutants, <i>jag2b</i> mutants and <i>jag2b</i>-overexpressing embryos, Jagged1a, Jagged1b and Jagge... by Yu-Fen Lu (171691)

“…Substantial decreases in <i>pvalb8</i>-positive cell numbers were observed in the trunks and yolks of embryos injected with <i>jag1a</i> UTRMO at 24 hpf. …”

Inactivation of <i>Francisella tularensis</i> Gene Encoding Putative ABC Transporter Has a Pleiotropic Effect upon Production of Various Glycoconjugates by Vera Dankova (1392487)

“…In contrast to <i>ΔpglA</i>, inactivation of <i>FTS_1402</i> had a pleiotropic effect, leading to alteration in glycosylation and, importantly, to decrease in lipopolysaccharide, capsule, and/or capsule-like complex production, which were reflected by distinct phenotypes in host–pathogen associated properties and virulence potential of the two mutant strains. …”

Palladium(II), Platinum(II), and Iridium(I) Complexes of 2-Phosphino-1-dimethylaminoferrocenes: A Survey of Structure and Catalysis by Costa Metallinos (2328832)

“…The new complexes displayed a structural trend relating a decrease in heteroatom-metal bond length with an increase in ligand bite angle on going from Ir to Pd and Pt. …”

Changes in HbA_1c levels (%) from baseline in response to three weeks at the DRC. by Helmuth Haslacher (402495)

“…<p>[a] Dependence of relative improvement on initial HbA_1c concentration; [b] individual changes in HbA_1c: vertical lines denote the respective changes in HbA_1c incurred at discharge (vs. at admission) by single patients with type 2 diabetes, and black circles values reached at discharge showing 27% to stay below and 8% to reach an HbA_1c <6.5%, while in 11% HbA_1c decreased to <7.0%, i.e. to therapeutic target. …”

Image2_Uncovering structural variants associated with body weight and obesity risk in labrador retrievers: a genome-wide study.TIF by Michal Antkowiak (17011314)

“…Obesity status was based on a 5-point body condition score (BCS) and the obese dog group included all dogs with a BCS of 5, along with dogs with the highest body weight within the BCS 4 group. …”

Resistant parasites exhibit deficient binding and uptake of UDA-FITC. by Víctor M. Castillo-Acosta (699651)

“…B) Microscopy images of fixed cells showing the decrease in UDA-labeling of UDA15a and UDA15b cells in comparison to parental <i>T</i>. …”

Image1_Uncovering structural variants associated with body weight and obesity risk in labrador retrievers: a genome-wide study.TIF by Michal Antkowiak (17011314)

“…Obesity status was based on a 5-point body condition score (BCS) and the obese dog group included all dogs with a BCS of 5, along with dogs with the highest body weight within the BCS 4 group. …”

DICER+AGO2 enzymes cleave fluorogenic substrates into duplex products that are unstable at T>25°C. by Mark A. Bernard (608655)

“…<p>Enzymatic activity (37°C) is shown for the dsRNA DICER substrates (BoGD664AS * GD664S, <b>A</b>; BoGD664AS-dAdG * GD664S, <b>C</b>; BoPD664S * PD664AS, <b>E</b>; BoPD664S-dAdG * PD664AS, <b>G</b>) and fluorogenic siRNA BoPsi664 (BoPsi664S * Psi664AS; <b>I</b>) by AGO2 (120 nM) + DICER (30 nM) but not by <i>E</i>. …”

Inactivation of <i>Francisella tularensis</i> Gene Encoding Putative ABC Transporter Has a Pleiotropic Effect upon Production of Various Glycoconjugates by Vera Dankova (1392487)

“…In contrast to <i>ΔpglA</i>, inactivation of <i>FTS_1402</i> had a pleiotropic effect, leading to alteration in glycosylation and, importantly, to decrease in lipopolysaccharide, capsule, and/or capsule-like complex production, which were reflected by distinct phenotypes in host–pathogen associated properties and virulence potential of the two mutant strains. …”