Times series of pre- and post-fire summer precipitation totals, mean air temperatures, accumulated degree days, and mean water temperatures at (a-d) Boulder Creek, (e-h) Gibbon Riv... by Mussie T. Beyene (13123933)

Structure-Guided Development of Small-Molecule PRC2 Inhibitors Targeting EZH2–EED Interaction by Daohai Du (1714372)

“…Disruption of EZH2–embryonic ectoderm development (EED) protein–protein interaction (PPI) is a new promising cancer therapeutic strategy. We have previously reported the discovery of astemizole, a small-molecule inhibitor targeting the EZH2–EED PPI. …”

Image_6_Alpha-1 antitrypsin limits neutrophil extracellular trap disruption of airway epithelial barrier function.jpg by K. M. Hudock (14369595)

“…Bronchial epithelia exposed to NETs demonstrate visible gaps in E-cadherin staining, a decrease in full-length E-cadherin protein and the appearance of cleaved E-cadherin peptides. …”

Image_5_Alpha-1 antitrypsin limits neutrophil extracellular trap disruption of airway epithelial barrier function.jpg by K. M. Hudock (14369595)

“…Bronchial epithelia exposed to NETs demonstrate visible gaps in E-cadherin staining, a decrease in full-length E-cadherin protein and the appearance of cleaved E-cadherin peptides. …”

Image_1_Alpha-1 antitrypsin limits neutrophil extracellular trap disruption of airway epithelial barrier function.jpg by K. M. Hudock (14369595)

“…Bronchial epithelia exposed to NETs demonstrate visible gaps in E-cadherin staining, a decrease in full-length E-cadherin protein and the appearance of cleaved E-cadherin peptides. …”

Table_2_Alpha-1 antitrypsin limits neutrophil extracellular trap disruption of airway epithelial barrier function.pdf by K. M. Hudock (14369595)

“…Bronchial epithelia exposed to NETs demonstrate visible gaps in E-cadherin staining, a decrease in full-length E-cadherin protein and the appearance of cleaved E-cadherin peptides. …”

Image_2_Alpha-1 antitrypsin limits neutrophil extracellular trap disruption of airway epithelial barrier function.jpg by K. M. Hudock (14369595)

“…Bronchial epithelia exposed to NETs demonstrate visible gaps in E-cadherin staining, a decrease in full-length E-cadherin protein and the appearance of cleaved E-cadherin peptides. …”

Image_4_Alpha-1 antitrypsin limits neutrophil extracellular trap disruption of airway epithelial barrier function.jpg by K. M. Hudock (14369595)

“…Bronchial epithelia exposed to NETs demonstrate visible gaps in E-cadherin staining, a decrease in full-length E-cadherin protein and the appearance of cleaved E-cadherin peptides. …”

Table_1_Alpha-1 antitrypsin limits neutrophil extracellular trap disruption of airway epithelial barrier function.pdf by K. M. Hudock (14369595)

“…Bronchial epithelia exposed to NETs demonstrate visible gaps in E-cadherin staining, a decrease in full-length E-cadherin protein and the appearance of cleaved E-cadherin peptides. …”

Image_3_Alpha-1 antitrypsin limits neutrophil extracellular trap disruption of airway epithelial barrier function.jpg by K. M. Hudock (14369595)

“…Bronchial epithelia exposed to NETs demonstrate visible gaps in E-cadherin staining, a decrease in full-length E-cadherin protein and the appearance of cleaved E-cadherin peptides. …”

Image_1_Trace Metal Dynamics in a Tropical Mangrove Tidal Creek: Influence of Porewater Seepage (Can Gio, Vietnam).jpg by Nguyen Thanh-Nho (9259460)

“…Previous studies demonstrated a decrease of trace metal stocks in mangrove soils seaward, possibly due to the export of dissolved metals through tidal pumping. …”

Image_2_Trace Metal Dynamics in a Tropical Mangrove Tidal Creek: Influence of Porewater Seepage (Can Gio, Vietnam).jpg by Nguyen Thanh-Nho (9259460)

“…Previous studies demonstrated a decrease of trace metal stocks in mangrove soils seaward, possibly due to the export of dissolved metals through tidal pumping. …”

Optimization of albuminuria lowering treatment in diabetes by cross-over rotation to four different drug classes – a randomized cross-over trial by Viktor Rotbain Curovic (9182235)

“…<p>  </p> <p><strong>Introduction</strong>: Renin-angiotensin-system (RAS) inhibitors decrease urinary albumin:creatinine ratio (UACR) but are ineffective in up to 40% of patients. …”

Predicted loss of function (pLOF) variants per exonic base pair versus non-synonymous to synonymous SNP ratio. by Zackery E. Plyler (18570572)

Small heterodimer partner (SHP) deficiency protects myocardia from lipid accumulation in high fat diet-fed mice by Jung Hun Ohn (10089)

“…According to microarray analysis, genes regulated by PPARγ1 and PPARα were down-regulated in myocardia of SHP KO mice compared to their expression in WT mice after HFD, suggesting that the reduction in lipid accumulation in the myocardium resulted from a decrease in lipogenesis regulated by PPARγ. We confirmed the reduced expression of PPARγ1 and PPARα target genes such as CD36, medium-chain acyl-CoA dehydrogenase, long-chain acyl-CoA dehydrogenase, and very long-chain acyl-CoA dehydrogenase by SHP KO after HFD.…”

Altered ERK 1/2 and Smad 1/5/8 phosphorylation observed in primary rat hippocampal cells upon iAβ expression. by Eric Cruz (340766)

“…Decreased ERK 1/2 phosphorylation in iAβ expressing cells is rescued upon pre-treatment with PLX4032. …”

Periconceptional folate consumption is associated with neonatal DNA methylation modifications in neural crest regulatory and cancer development genes by Semira Gonseth (665194)

“…We measured genome-wide DNA methylation from neonatal blood spots. We implemented a method based on bootstrap resampling to decrease false-positive findings. …”

A Theoretical Investigation of the Plausibility of Reactions between Ammonia and Carbonyl Species (Formaldehyde, Acetaldehyde, and Acetone) in Interstellar Ice Analogs at Ultracold... by Lina Chen (87129)

“…We found that while the barrier for the concerted proton relay mechanism described in previous work remains modest, it is still prohibitively high for the reaction to occur under the ultracold conditions that prevail in dense interstellar clouds. However, a new pathway emerged in more realistic clusters that involves at least one barrierless step for two of the carbonyl species considered here: ammonia reacts with formaldehyde and acetaldehyde to form a partial charge transfer species in small clusters (4H₂O) and a protonated hydroxyamino intermediate species in large clusters (9H₂O, 12H₂O); modest barriers that decrease sharply with cluster size are found for the analogous processes for the acetone-NH₃ reaction. …”

Supplementary Material for: Interactive Motion-Assisted Exposure Therapy for Veterans with Treatment-Resistant Posttraumatic Stress Disorder: A Randomized Controlled Trial by vanGelderen M.J. (8609901)

“…<b><i>Conclusions:</i></b> In this trial, 3MDR significantly decreased PTSD symptoms in veterans with, on average, a history of 4 unsuccessful treatments. …”

Data_Sheet_1_Changes in the Number of Medal Events, Sport Events, and Classes During the Paralympic Games: A Historical Overview.xlsx by Julia Kathrin Baumgart (4884799)

“…While this suggested an increased sports participation among athletes with disabilities, it made the PG difficult to organize. A decrease in the number of medal events subsequently occurred during the SG (1984–1992: 975–489) and WG (1994–2006: 133–58). …”