Effect of tunable directional persistence on tests of motion bias for a simple mathematical model of stochastic swimming paths. by Leah Armon (178552)

“…This involves the risk of type-II errors (“false negatives”), in which biased motion is falsely classified as unbiased (the null hypothesis is falsely accepted). The rate of such a type-II errors decreases with sample size <i>N</i>, but increases with the persistence time τ of the biased persistent random walks (green: τ = 0.1Δ<i>t</i>, red: τ = Δ<i>t</i>, blue: <i>τ</i> = 10Δ<i>t</i>). …”

In Vivo Response to Methotrexate Forecasts Outcome of Acute Lymphoblastic Leukemia and Has a Distinct Gene Expression Profile by Michael J Sorich (275350)

“…Therefore, we measured the in vivo antileukemic effects of MTX and identified genes whose expression differed significantly in patients with a good versus poor response to MTX.</p> <h3>Methods and Findings</h3><p>We utilized measures of decreased circulating leukemia cells of 293 newly diagnosed children after initial “up-front” in vivo MTX treatment (1 g/m²) to elucidate interpatient differences in the antileukemic effects of MTX. …”

(a) Root mean square deviation RMSD between the experimental data (green bars in Fig. 3 (c, d)) and the simulated dwell time distributions for the three-cycle network as a function... by Veronika Bierbaum (281564)

“…<p>A lower deviation indicates an improved agreement between the experimental values and the distributions that result from the three-cycle network. …”

Angiogenic and pleiotropic effects of VEGF165 and HGF combined gene therapy in a rat model of myocardial infarction by Pavel I. Makarevich (5249657)

“…Thus, combined methods using delivery of several angiogenic factors got into spotlight as a way to improve outcomes. This study provides experimental proof of concept for a combined approach using simultaneous delivery of VEGF165 and HGF genes to alleviate consequences of myocardial infarction (MI). …”

Data S1 - Dietary Stearic Acid Leads to a Reduction of Visceral Adipose Tissue in Athymic Nude Mice by Ming-Che Shen (629982)

“…These data showed that stearic acid decreased the expression of cIAP2 and Bcl2 (although only cIAP2 was significant (n = 6 replicates, p<0.01), which encodes antiapoptotic proteins, and increased Bax gene expression, which encodes for a proapoptotic protein, when compared to control cells. …”

The CIC system predicts a <i>Virtual-Electrode</i> along the ER membrane under realistic parameters. by Isaac Shemer (43424)

“…(D) Parameter dependency of VE amplitude and pattern: <i>V</i>_mE was recalculated after increasing (blue) or decreasing (red) <i>N</i> or <i>E</i> (the non-conductive cross-section or the ER cross-section, respectively) by 15% from the default parameters (gray) provided in <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1000036#pcbi-1000036-t002" target="_blank">Table 2</a>. …”

TRMT61B is responsible for m¹A947 in mitochondrial 16S rRNA. by Dan Bar-Yaacov (824750)

“…<p>(A) Detection of hypomodified m¹A947 in mitochondrial 16S rRNA from siRNA-treated HeLa cells. …”

CASY-1 interacts with the kinesin motor UNC-104/KIF1A to regulate the trafficking of GABA vesicles. by Shruti Thapliyal (4951993)

“…<p>(A) FRAP analysis of SNB-1::GFP levels in GABAergic motor neurons reveals that the dynamics of SV mobility is reduced after <i>unc-104</i> RNAi. …”

Divergent signalling pathways mediate the effects of Aβ on Homer1b and Shank1 cluster dispersal. by Francesco Roselli (211670)

“…Wort+Aβ and Wort alone; p<0.05). Notably, wortmannin itself decreased Shank1 (but not Homer1b) cluster size (74.3±10.3%, cf. …”

Artemether-lumefantrine dosing for malaria treatment in young children and pregnant women: A pharmacokinetic-pharmacodynamic meta-analysis by Frank Kloprogge (5374169)

“…</p><p>Methods and findings</p><p>A search in PubMed, Embase, ClinicalTrials.gov, Google Scholar, conference proceedings, and the WorldWide Antimalarial Resistance Network (WWARN) pharmacology database identified 31 relevant clinical studies published between 1 January 1990 and 31 December 2012, with 4,546 patients in whom lumefantrine concentrations were measured. …”

Assessing the benefits of five years of different approaches to treatment of urogenital schistosomiasis: A SCORE project in Northern Mozambique by Anna E. Phillips (4050331)

“…<i>haematobium</i> was seen in adults even in the SBT arms implying the rate of transmission in the community had been decreased, even where only school children have been treated, which has significant logistical and cost-saving implications for a national control programme in justifying CWT.…”

Current situation and progress toward the 2030 health-related Sustainable Development Goals in China: A systematic analysis by Shu Chen (363692)

“…<div><p>Background</p><p>The Sustainable Development Goals (SDGs), adopted by all United Nations (UN) member states in 2015, established a set of bold and ambitious health-related targets to achieve by 2030. …”

Postmenopausal hormone therapy and risk of stroke: A pooled analysis of data from population-based cohort studies by Germán D. Carrasquilla (4600603)

“…Our results suggest that the initiation of HT 0–5 years after menopause onset, as compared to never use, is associated with a decreased risk of stroke and haemorrhagic stroke. …”

Substituent Effect on the Luminescent Properties of a Series of Deep Blue Emitting Mixed Ligand Ir(III) Complexes by Yi-Yeol Lyu (2540962)

“…The <b>(P3)F2M</b> complex shows a maximum external quantum efficiency (η_ex) of 2%, a maximum luminance efficiency (η_L) of 4.13 cd/A at 0.04 mA/cm², and a maximum brightness of 7200 cd/m² with a shift of the Commission Internationale de L'Eclairage (CIE) coordinates from (0.14, 0.15) in film PL to (0.19, 0.34) in EL.…”

Substituent Effect on the Luminescent Properties of a Series of Deep Blue Emitting Mixed Ligand Ir(III) Complexes by Yi-Yeol Lyu (2540962)

“…The <b>(P3)F2M</b> complex shows a maximum external quantum efficiency (η_ex) of 2%, a maximum luminance efficiency (η_L) of 4.13 cd/A at 0.04 mA/cm², and a maximum brightness of 7200 cd/m² with a shift of the Commission Internationale de L'Eclairage (CIE) coordinates from (0.14, 0.15) in film PL to (0.19, 0.34) in EL.…”

Comparison of our CCR5-CCL5-I and -II systems with the experimental structure (PDB ID: 7O7F), a complex of CCR5 with a modified CCL5 chemokine, the super-agonist [6P4]CCL5. by Guillermo Goode-Romero (11476663)

“…<p>(A) The RMSD of the backbone with a defined secondary structure (<i>i</i>.…”

LET-653 is a luminal ZP protein that shapes <i>C</i>. <i>elegans</i> tubes. by Jennifer D. Cohen (2902514)

“…<p>A) Diagram of LET-653 isoform b, on which all structure/function constructs were based. …”

Effects of Exercise Types on Muscle Strength and Body Composition in Men and Women: A Systematic Review and Meta-analysis by Ki-Woong Noh (16801002)

“…Physical activity plays a very important role in preventing and improving problems such as decreased physical ability, sarcopenia, and sarcopenic obesity. …”

Status of methylation at the CpG site in the maspin promoter region of TEV-1 cells upon hypoxia and DI A-D: Bisulfite sequencing revealed a methylated CpG island in the maspin prom... by Xinwei Shi (782237)

Differentially expressed genes involved in Wnt signaling pathway in zebrafish spinal cord after injury and validation of <i>wnt8a</i>, <i>wnt4b</i>, <i>wnt7a</i> and <i>b- catenin<... by Subhra Prakash Hui (510710)

“…<p>A–D) Quantitative RT-PCR analysis of <i>wnt8a</i>, <i>b-catenin</i>, <i>wnt4b</i> and <i>wnt7a</i> respectively showing fold change (red graph) and temporal expression pattern after injury. …”