Table1_Multi-Scale Modeling Recapitulates the Effect of Genetic Alterations Associated With Diffuse Large B-Cell Lymphoma in the Germinal Center Dynamics.docx by Elena Merino Tejero (10102450)

“…Models with constitutive activation of the nuclear factor kappa-light-chain-enhancer of activated B-cell (NF-kB) pathway alone and in codominance or co-expression with the enforced BCL6 expression (IRF^inc and BCL^incIRF^inc) result in a decrease of GC B cells and unaltered PC production at early stages of the GC reaction, as observed experimentally. …”

Image_1_C2 IgM Natural Antibody Enhances Inflammation and Its Use in the Recombinant Single Chain Antibody-Fused Complement Inhibitor C2-Crry to Target Therapeutics to Joints Atten... by Nirmal K. Banda (1477765)

“…In mice with CIA, at day 35 there was a significant 39% (p < 0.042) decrease in the CDA in mice treated with C2-Crry. …”

Regional Outcome Evaluation Program (P.Re.Val.E.): Reduction of inequality in access to effective health care in the Lazio region of Italy (2012–2015) by Martina Ventura (5018948)

“…By comparing the adjusted proportions in patients with the highest education level (a university degree or higher) to those with the lowest level education level (None/Primary school), a decrease in the percentage difference was observed during the study period. …”

Smo ubiquitination is regulated by Hh and phosphorylation. by Ruohan Xia (188658)

“…(C) NIH3T3 cells were transfected with Myc-hSmo and treated with or without recombinant Shh. Shh induced a marked decrease in hSmo ubiquitination (lane 3). …”

Systematic Review of Screening and Surveillance Programs to Protect Workers from Nanomaterials by Mary Gulumian (668890)

“…Of these, six compared health indicators between exposed and unexposed workers and one study described a surveillance program. All studies were at a high risk of bias. …”

AKMT is important for invasion and egress, but not for parasite replication. by Aoife T. Heaslip (207534)

“…(C) The loss of AKMT results in a ∼90% decrease in invasion efficiency. The number of invaded parasites per field was counted in 10 fields each in 3 independent experiments. ***: P value <0.0001 (D) <i>Top</i>: Outline of A23187 induced egress assay. …”

Image_3_C2 IgM Natural Antibody Enhances Inflammation and Its Use in the Recombinant Single Chain Antibody-Fused Complement Inhibitor C2-Crry to Target Therapeutics to Joints Atten... by Nirmal K. Banda (1477765)

“…In mice with CIA, at day 35 there was a significant 39% (p < 0.042) decrease in the CDA in mice treated with C2-Crry. …”

2-AA down-regulates the transcription of many genes involved in the translational capacity of the cell. by Yok-Ai Que (70055)

“…The ratio of translating polysomes to 70S was higher in the untreated cultures (left) than in the cultures grown in presence of exogenously added 2-AA (right) reflecting a decrease in translational activity. <b>F</b>. …”

Increased <i>Toll-1, wek</i> and <i>sarm</i> levels can induce cell loss in the absence of infection. by Deepanshu N. D. Singh (20721878)

“…<p><b>(A,B)</b> In the absence of infection, over-expression of activated <i>Toll-1</i>^<i>10b</i> in DANs (with <i>THGAL4; R58E02GAL4</i>) caused a rather mild and not significant decrease in PAMs. …”

Image_9_Dual Effects of Cyclooxygenase Inhibitors in Combination With CD19.CAR-T Cell Immunotherapy.tif by Mingya Yang (1655299)

“…Although the cytokine release by CD19.CAR-T cells upon activation was not hampered by both COX-inhibitors, activation and proliferation of CAR-T cells were significantly inhibited via diminishing the NF-ĸB signaling pathway by a significant down-regulation of expression of CD27 on CD4⁺ and CD8⁺ CAR-T cells, followed by a clear decrease of phosphorylated NF-ĸB p65 in both CD4⁺ and CD8⁺ CAR-T cells by a factor of 1.8. …”

Image_7_Dual Effects of Cyclooxygenase Inhibitors in Combination With CD19.CAR-T Cell Immunotherapy.tif by Mingya Yang (1655299)

“…Although the cytokine release by CD19.CAR-T cells upon activation was not hampered by both COX-inhibitors, activation and proliferation of CAR-T cells were significantly inhibited via diminishing the NF-ĸB signaling pathway by a significant down-regulation of expression of CD27 on CD4⁺ and CD8⁺ CAR-T cells, followed by a clear decrease of phosphorylated NF-ĸB p65 in both CD4⁺ and CD8⁺ CAR-T cells by a factor of 1.8. …”

Image_1_Sex-related differences in the response of anti-platelet drug therapies targeting purinergic signaling pathways in sepsis.jpeg by Emmanuel Boadi Amoafo (14045520)

“…CLP males treated with ticagrelor or MRS2279 showed a decrease in sepsis-induced MPO levels in lung and kidneys, aggregate formation, and platelet activation as compared to untreated male CLP mice. …”

Image_4_Dual Effects of Cyclooxygenase Inhibitors in Combination With CD19.CAR-T Cell Immunotherapy.tif by Mingya Yang (1655299)

“…Although the cytokine release by CD19.CAR-T cells upon activation was not hampered by both COX-inhibitors, activation and proliferation of CAR-T cells were significantly inhibited via diminishing the NF-ĸB signaling pathway by a significant down-regulation of expression of CD27 on CD4⁺ and CD8⁺ CAR-T cells, followed by a clear decrease of phosphorylated NF-ĸB p65 in both CD4⁺ and CD8⁺ CAR-T cells by a factor of 1.8. …”

Image_2_C2 IgM Natural Antibody Enhances Inflammation and Its Use in the Recombinant Single Chain Antibody-Fused Complement Inhibitor C2-Crry to Target Therapeutics to Joints Atten... by Nirmal K. Banda (1477765)

“…In mice with CIA, at day 35 there was a significant 39% (p < 0.042) decrease in the CDA in mice treated with C2-Crry. …”

Knock-out of <i>atp6v1e1b</i> in zebrafish shows an early phenotypic read-out. by Lore Pottie (10994479)

“…(B) RT-qPCR analysis showed a significant decrease in expression of <i>atp6v1e1b</i> in both zebrafish models at 3 dpf. …”

Data_Sheet_1_Concerted suppressive effects of carisbamate, an anti-epileptic alkyl-carbamate drug, on voltage-gated Na+ and hyperpolarization-activated cation currents.docx by Te-Yu Hung (15861305)

“…However, CRS strongly decreased the strength (i.e., Δarea) of the nonlinear window component of I_Na (I_Na(W)), which was activated by a short ascending ramp voltage (V_ramp); the subsequent addition of deltamethrin (DLT, 10 μM) counteracted the ability of CRS (100 μM, continuous exposure) to suppress I_Na(W). …”

Table_1_Qingrequzhuo capsule alleviated methionine and choline deficient diet-induced nonalcoholic steatohepatitis in mice through regulating gut microbiota, enhancing gut tight ju... by Shuquan Lv (11897978)

“…In addition, QRQZ treatment decreased the levels of inflammatory cytokines in liver. 16S rRNA sequencing showed that QRQZ affected the diversity of gut microbiota and a f f e c t e d t h e r e l a t i v e a b u n d a n c e s o f D u b o s i e l l a , Lachnospiraceae_NK4A136_group, and Blautiain NASH mice. …”

Image_10_Dual Effects of Cyclooxygenase Inhibitors in Combination With CD19.CAR-T Cell Immunotherapy.tif by Mingya Yang (1655299)

“…Although the cytokine release by CD19.CAR-T cells upon activation was not hampered by both COX-inhibitors, activation and proliferation of CAR-T cells were significantly inhibited via diminishing the NF-ĸB signaling pathway by a significant down-regulation of expression of CD27 on CD4⁺ and CD8⁺ CAR-T cells, followed by a clear decrease of phosphorylated NF-ĸB p65 in both CD4⁺ and CD8⁺ CAR-T cells by a factor of 1.8. …”

Image_12_Dual Effects of Cyclooxygenase Inhibitors in Combination With CD19.CAR-T Cell Immunotherapy.tif by Mingya Yang (1655299)

“…Although the cytokine release by CD19.CAR-T cells upon activation was not hampered by both COX-inhibitors, activation and proliferation of CAR-T cells were significantly inhibited via diminishing the NF-ĸB signaling pathway by a significant down-regulation of expression of CD27 on CD4⁺ and CD8⁺ CAR-T cells, followed by a clear decrease of phosphorylated NF-ĸB p65 in both CD4⁺ and CD8⁺ CAR-T cells by a factor of 1.8. …”

Image_11_Dual Effects of Cyclooxygenase Inhibitors in Combination With CD19.CAR-T Cell Immunotherapy.tif by Mingya Yang (1655299)

“…Although the cytokine release by CD19.CAR-T cells upon activation was not hampered by both COX-inhibitors, activation and proliferation of CAR-T cells were significantly inhibited via diminishing the NF-ĸB signaling pathway by a significant down-regulation of expression of CD27 on CD4⁺ and CD8⁺ CAR-T cells, followed by a clear decrease of phosphorylated NF-ĸB p65 in both CD4⁺ and CD8⁺ CAR-T cells by a factor of 1.8. …”