Image_1_Mitochondrial topoisomerase 1 inhibition induces topological DNA damage and T cell dysfunction in patients with chronic viral infection.jpeg by Xindi Dang (10742208)

“…Moreover, treatment of CD4 T cells from HCV or HIV patients with CPT further increased cellular and mitochondrial reactive oxygen species (ROS) production and cell apoptosis, demonstrating a critical role for Top1 in preventing mtDNA damage and cell death. …”

Data_Sheet_1_Mechanism of fungal remediation of wetland water: Stropharia rugosoannulata as promising fungal species for the development of biofilters to remove clinically importan... by Keya Sen (2223421)

“…Biofilter jars were incubated with wetland water (WW) obtained from a crow roost area that was additionally spiked with AMR bacteria isolated from previous crow fecal collections. …”

Table2_BMI1 fine-tunes gene repression and activation to safeguard undifferentiated spermatogonia fate.XLSX by Ruiqi Liu (3873832)

“…B cell-specific Moloney murine leukemia virus integration site 1 (BMI1), one of spermatogonial stem cell markers, is a member of Polycomb repressive complex 1 (PRC1) and important to spermatogenesis. …”

Table_1_Methylation-mediated silencing of EDN3 promotes cervical cancer proliferation, migration and invasion.docx by Peng Zhu (277243)

“…EDN3 silencing mediated by methylation can be blocked by 5-Azacytidine (5-Aza), a DNA methyltransferase 1 (DNMT1) inhibitor, treatment in cervical cancer cell lines. …”

DataSheet_1_Elevated Biomarkers of NETosis in the Serum of Pediatric Patients With Type 1 Diabetes and Their First-Degree Relatives.docx by Adam Klocperk (671607)

“…Recent evidence demonstrated that neutrophils infiltrate the pancreas prior to disease onset and therein extrude neutrophil extracellular traps (NETs), web-like structures of DNA and nuclear proteins with a strong pro-inflammatory biologic activity. Our previous work showed that T1D NETs activate dendritic cells, which consequently induce IFNγ-producing Th1 lymphocytes. …”

Table_2_Functional and Morphological Characterization of Small and Large Steroidogenic Luteal Cells From Domestic Cats Before and During Culture.DOCX by Michał M. Hryciuk (7862249)

“…The expression of receptors for gonadotropins and prolactin also decreased. Prostaglandin synthase (PTGS2) decreased steadily over time, whereas mRNA expression of PGE2 synthase (PGES) increased. …”

Synthesis, crystal structures, and anticancer studies of Ni(II), Co(III), and Zn(II) complexes derived from chlorinated-2-(2-aminophenyl)-1H-benzimidazole Schiff base by Hou Cong Li (20668174)

“…The <i>in vitro</i> cytotoxicity of chlorinated ligand and its metal complexes were evaluated on four different tumor cell lines (A-549 lung cancer, SMMC-7721 liver cancer, MDA-MB-231 breast cancer, and CNE-2Z nasopharyngeal carcinoma), and normal ovarian epithelial cell (IOSE 80) was determined by MTT assay. …”

Image_1_Detrimental effects of soluble α-synuclein oligomers at excitatory glutamatergic synapses.PDF by Elena Ferrari (30903)

“…Conversely, chronic in vitro administration of sOligo caused a significant decrease in ERK phosphorylation but did not significantly alter post-synaptic levels of ionotropic glutamate receptors or spine density in primary hippocampal neurons.…”

Image_4_Low-Intensity Focused Ultrasound Stimulation Ameliorates Working Memory Dysfunctions in Vascular Dementia Rats via Improving Neuronal Environment.TIF by Faqi Wang (2072857)

“…This study adds to the evidence that LIFUS could become a promising and non-invasive treatment strategy for the clinical treatment of central nervous system diseases related to cognitive impairments in the future.…”

Image_2_Pu-Erh Tea Relaxes the Thoracic Aorta of Rats by Reducing Intracellular Calcium.tif by Dan Luo (192943)

“…Furthermore, pu-erh aqueous extract attenuated the KCl-induced increase in [Ca²⁺]_i in cultured rat aortic smooth muscle A7r5 cells. In addition, the chloroform precipitate of pu-erh aqueous extract produced the most potent vasodilation. …”

Image_3_Bacteroides thetaiotaomicron Ameliorates Experimental Allergic Airway Inflammation via Activation of ICOS+Tregs and Inhibition of Th2 Response.tif by Wenhui Pang (394103)

“…Therefore, our data indicate that oral administration of B. thetaiotaomicron effectively inhibited the development of AAD in murine model; inhibition was mediated by the activation of Tregs and inhibition of Th2 response without promoting a Th1 response.</p>…”

Image_1_Pu-Erh Tea Relaxes the Thoracic Aorta of Rats by Reducing Intracellular Calcium.tif by Dan Luo (192943)

“…Furthermore, pu-erh aqueous extract attenuated the KCl-induced increase in [Ca²⁺]_i in cultured rat aortic smooth muscle A7r5 cells. In addition, the chloroform precipitate of pu-erh aqueous extract produced the most potent vasodilation. …”

Genetic Regulation of α-Synuclein mRNA Expression in Various Human Brain Tissues by Colton Linnertz (258148)

Table_5_Weaning Induces Stress-Dependent DNA Methylation and Transcriptional Changes in Piglet PBMCs.XLSX by Ryan J. Corbett (9572093)

“…We observed post-weaning hypermethylation of the glucocorticoid receptor (NR3C1) promoter and a significant decrease in NR3C1 expression (n = 9, p = 6.1 × 10^–3). …”

Image4_BMI1 fine-tunes gene repression and activation to safeguard undifferentiated spermatogonia fate.TIF by Ruiqi Liu (3873832)

“…B cell-specific Moloney murine leukemia virus integration site 1 (BMI1), one of spermatogonial stem cell markers, is a member of Polycomb repressive complex 1 (PRC1) and important to spermatogenesis. …”

Image_2_Mitochondrial topoisomerase 1 inhibition induces topological DNA damage and T cell dysfunction in patients with chronic viral infection.tif by Xindi Dang (10742208)

“…Moreover, treatment of CD4 T cells from HCV or HIV patients with CPT further increased cellular and mitochondrial reactive oxygen species (ROS) production and cell apoptosis, demonstrating a critical role for Top1 in preventing mtDNA damage and cell death. …”

Table_7_Weaning Induces Stress-Dependent DNA Methylation and Transcriptional Changes in Piglet PBMCs.XLSX by Ryan J. Corbett (9572093)

“…We observed post-weaning hypermethylation of the glucocorticoid receptor (NR3C1) promoter and a significant decrease in NR3C1 expression (n = 9, p = 6.1 × 10^–3). …”

The effect of salts, pH and additives in the lysis buffer on the solubility of RGP1. by Ditte Hededam Welner (4099906)

“…<p>Western blots against a cloning scar shows the varying amount of RGP1 in the soluble lysis fraction after lysing in different buffers. …”

Table_1_Mutation at Different Sites of Metal Transporter Gene OsNramp5 Affects Cd Accumulation and Related Agronomic Traits in Rice (Oryza sativa L.).docx by Tiankang Wang (7369577)

“…<p>OsNramp5 is a key gene involved in the control of the uptake of Cd, Mn, and other metal ions by rice root cells. …”

Inhibition of DC Expansion following TMEV Infection via Apoptosis and Growth Arrest by Wanqiu Hou (78785)

“…<div><p>(A) BMCs were cultured with GM-CSF for 3 d and then mock-infected or infected with TMEV. …”