<i>Mycobacterium tuberculosis</i> universal stress protein Rv2623 interacts with the putative ATP binding cassette (ABC) transporter Rv1747 to regulate mycobacterial growth by Lisa N. Glass (4285222)

“…Biochemical, immunochemical and mass spectrometric studies have shown that Rv2623 harbors pT and specifically identified threonine 237 as a phosphorylated residue. Relative to wild-type Rv2623 (Rv2623_WT), a mutant protein in which T237 has been replaced with a non-phosphorylatable alanine (Rv2623_T237A) exhibits decreased interaction with the Rv1747 FHA I domain and diminished growth-regulatory capacity. …”

Abundance of antisense transcripts in <i>RTR1/RRP6</i> double deletion strain phenocopies <i>rrp6Δ</i> cells. by Jose F. Victorino (8595885)

“…Each genotype clustered together illustrating a high degree of reproducibility between biological replicates with WT values groups as Cluster IV, <i>rtr1Δ</i> values grouped as Cluster III, <i>rtr1Δ rrp6Δ</i> grouped as Cluster II, and <i>rrp6Δ</i> grouped as Cluster I. …”

In vivo validation of hippocampal avoidance with radiation in rats treated with brain irradiation with hippocampal avoidance. by C. K. Cramer (833725)

“…The radiation-induced phosphorylation of Histone H2A.X in the hippocampus is significantly decreased when the brain is irradiated with hippocampal avoidance, * P = 0.012 (by student t-test). …”

Presentation_1_Utility of a Novel Three-Dimensional and Dynamic (3DD) Cell Culture System for PK/PD Studies: Evaluation of a Triple Combination Therapy at Overcoming Anti-HER2 Trea... by Anusha Ande (724831)

“…In the 3DD cell culture setting, sequential dosing of PAC then EVE+DAS showed a 5-fold increase in caspase-3 activity and 8.5-fold decrease in the total cell number compared to the control. …”

Expression of osteoblast differentiation markers following <i>BST2</i> knockdown. by Su-Hyang Yoo (3160983)

Therapist rotation: a novel approach for implementation of trauma-focused treatment in post-traumatic stress disorder by Agnes Van Minnen (8060513)

“…We explore the experiences with this model from both a therapist and a patient perspective.<b>Results</b>: Our findings were promising in that they suggested that this novel approach reduced the therapists’ fear of providing TFT to PTSD patients, increased perceived readiness for TFT, and decreased avoidance behaviour within TFT sessions, possibly leading to better implementation of TFT. …”

AntagomiR-treated flies display metabolic defects similar to miR-275/305 mutants. by Junfei Xie (3148638)

“…<p>(A) miRNA inhibition efficiency was determined by qRT-PCR at 2 d post antagomiR injection with scrambled sequences as negative controls (Ant-NC). …”

Electrospun Polyimide Nanofiber-Based Triboelectric Nanogenerator for Harvesting Energy at Elevated Temperatures by Feilong Shi (13803714)

“…The PINF-TENG generated an open-circuit voltage of 60.83 V and a short-circuit current of 1.52 μA at 25 °C, and a peak power density of 17.36 mW/m² was achieved on a 50 MΩ external load. …”

The correlation between external apical root resorption and electric pulp test responses: a prospective clinical trial by Farnaz YOUNESSIAN (12853367)

“…Conclusion: The relative decrease in electric pulp test level could be a diagnostic sign of root resorption during orthodontic treatment. …”

Identifying Insects with Incomplete DNA Barcode Libraries, African Fruit Flies (Diptera: Tephritidae) as a Test Case by Massimiliano Virgilio (182967)

“…In all cases, more restrictive distance thresholds produced a gradual increase in the proportion of true negatives, a gradual decrease of false positives and more abrupt variations in the proportions of true positives and false negatives. …”

Purification, characterization, and antitumor activity of a novel glucan from the fruiting bodies of <i>Coriolus Versicolor</i> by Annoor Awadasseid (3726955)

“…Structural analysis revealed that CVG has a linear α-glucan chain composed of only (1→ 6)-α-D-Glc<i>p</i>. …”

Discovery of the Diphenyl 6‑Oxo-1,6-dihydropyridazine-3-carboxylate/carboxamide Analogue J27 for the Treatment of Acute Lung Injury and Sepsis by Targeting JNK2 and Inhibiting the... by Jing Liao (193197)

“…The optimal compound <b>J27</b> decreased the release of TNF-α and IL-6 in mouse and human cells J774A.1 and THP-1 (IL-6 IC₅₀ = 0.22 μM) through the NF-κB/MAPK pathway. …”

Discovery of the Diphenyl 6‑Oxo-1,6-dihydropyridazine-3-carboxylate/carboxamide Analogue J27 for the Treatment of Acute Lung Injury and Sepsis by Targeting JNK2 and Inhibiting the... by Jing Liao (193197)

“…The optimal compound <b>J27</b> decreased the release of TNF-α and IL-6 in mouse and human cells J774A.1 and THP-1 (IL-6 IC₅₀ = 0.22 μM) through the NF-κB/MAPK pathway. …”

Label-Free Interactome Analysis Revealed an Essential Role of CUL3-KEAP1 Complex in Mediating the Ubiquitination and Degradation of PHD2 by Ang Luo (8097296)

“…Prolyl hydroxylase domain-containing protein 2 (PHD2/EGLN1) is a key regulatory enzyme that plays a fundamental role in the cellular hypoxic response pathway, mediating proline hydroxylation-dependent protein degradation of selected target proteins. …”

Loss of ATRX and SLF2 enables telomere exchanges. by William A. Scott (11707932)

“…<p>A: DNA sequencing and western blotting confirming the disruption of ATRX expression in CRISPR-Cas9-edited HEK293 Flp-In T-REx cells inducibly expressing RAP1-BirA*. …”

Label-Free Interactome Analysis Revealed an Essential Role of CUL3-KEAP1 Complex in Mediating the Ubiquitination and Degradation of PHD2 by Ang Luo (8097296)

“…Prolyl hydroxylase domain-containing protein 2 (PHD2/EGLN1) is a key regulatory enzyme that plays a fundamental role in the cellular hypoxic response pathway, mediating proline hydroxylation-dependent protein degradation of selected target proteins. …”

Phosphorylation of p27^Kip1 at S140 regulates its protein stability in the G1-phase of the cell cycle. by Erica K. Cassimere (3111996)

“…<p>(A) Ectopically expressed p27^Kip1 S140A mutant has a decreased half-life compared with the WT or phosphomimetic (S140D) versions. …”

Comparative Transcriptomic Analysis of Primary Duck Hepatocytes Provides Insight into Differential Susceptibility to DHBV Infection by Liang Yan (494300)

“…After re-annotation against human genome data, the 384 DEGs were pooled together with proteins belonging to hepatitis B pathway to construct a protein-protein interaction network. The combination of decreased expression of liver-specific genes (CYP3A4, CYP1E1, CFI, RELN and GSTA1 et al) with increased expression of hepatocyte-dedifferentiation-associated genes (PLA2G4A and PLCG1) suggested that <i>in vitro</i> culture conditions results in the fading of hepatocyte phenotype in PDHs. …”

mGluR1 activity regulates cell proliferation. by Malathi Banda (505556)

“…<p><b>A. Proliferation.</b> mGluR1 overexpression significantly increased proliferation of MCF10AT1 cells compared to the control as measured by MTT assay. …”

Immunomodulation by gastrointestinal carbon black nanoparticle exposure in ovalbumin T cell receptor transgenic mice by Jason H. Fine (3109035)

“…Exposure to OVA resulted in significant increases in serum anti-OVA IgG1, anti-OVA IgM, and anti-OVA IgA antibodies relative to vehicle control. Immunophenotyping revealed a reduction in the number of OVA-specific CD4⁺T helper cells upon OVA ± CBNP^HI treatment in the spleen. …”